| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,118,616 | 42,267,000 | 14.67% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 1,515,122 | 30,227,000 | 10.49% | ||
| 3 | Broadfin Capital, LLC | 959,247 | 19,137,000 | 6.64% | ||
| 4 | Novo Holdings A/S | 900,000 | 17,955,000 | 6.23% | ||
| 5 | JENNISON ASSOCIATES LLC | 648,114 | 12,930,000 | 4.49% | ||
| 6 | VANGUARD GROUP INC | 523,828 | 10,450,000 | 3.63% | ||
| 7 | BlackRock Fund Advisors | 519,734 | 10,369,000 | 3.60% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 504,548 | 10,066,000 | 3.49% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 500,401 | 9,983,000 | 3.46% | ||
| 10 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 497,858 | 9,932,000 | 3.45% | ||
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 450,191 | 8,981,000 | 3.12% | ||
| 12 | FIL Ltd | 444,984 | 8,877,000 | 3.08% | ||
| 13 | HARVEY CAPITAL MANAGEMENT INC | 354,300 | 7,068,000 | 2.45% | ||
| 14 | Granahan Investment Management, LLC | 308,360 | 6,152,000 | 2.13% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 300,900 | 6,003,000 | 2.08% | ||
| 16 | PointState Capital LP | 300,000 | 5,985,000 | 2.08% | ||
| 17 | STATE STREET CORP | 269,689 | 5,382,000 | 1.87% | ||
| 18 | NOMURA HOLDINGS INC | 253,165 | 4,860,000 | 1.69% | ||
| 19 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 230,750 | 4,604,000 | 1.60% | ||
| 20 | NORTHERN TRUST CORP | 225,660 | 4,502,000 | 1.56% | ||
| 21 | WELLS FARGO & COMPANY/MN | 220,711 | 4,403,000 | 1.53% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 210,959 | 4,209,000 | 1.46% | ||
| 23 | Opaleye Management Inc. | 169,700 | 3,385,515 | 1.17% | ||
| 24 | Informed Momentum Co LLC | 152,595 | 3,044,000 | 1.06% | ||
| 25 | Bank of New York Mellon Corp | 146,541 | 2,923,000 | 1.01% | ||
| 26 | TFS CAPITAL LLC | 133,070 | 2,655,000 | 0.92% | ||
| 27 | RUSSELL FRANK CO/ | 109,896 | 2,192,000 | 0.76% | ||
| 28 | C WorldWide Group Holding A/S | 100,000 | 1,998,000 | 0.69% | ||
| 29 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 95,979 | 1,915,000 | 0.66% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 89,534 | 1,786,000 | 0.62% | ||
| 31 | AXA S.A. | 80,089 | 1,598,000 | 0.55% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 79,579 | 1,588,000 | 0.55% | ||
| 33 | Invesco Ltd. | 78,303 | 1,562,000 | 0.54% | ||
| 34 | GABELLI FUNDS LLC | 77,000 | 1,536,000 | 0.53% | ||
| 35 | DEUTSCHE BANK AG\ | 74,173 | 1,478,000 | 0.51% | ||
| 36 | AMERIPRISE FINANCIAL INC | 69,626 | 1,389,000 | 0.48% | ||
| 37 | BlackRock Investment Management, LLC | 63,984 | 1,276,000 | 0.44% | ||
| 38 | GREEN ARROW CAPITAL MANAGEMENT LLC | 60,000 | 1,197,000 | 0.42% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,200 | 1,141,000 | 0.40% | Put | |
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,400 | 1,125,000 | 0.39% | Call | |
| 41 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 998,000 | 0.35% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,702 | 812,000 | 0.28% | ||
| 43 | Granite Point Capital Management, L.P. | 40,000 | 798,000 | 0.28% | ||
| 44 | SIT INVESTMENT ASSOCIATES INC | 35,340 | 705,000 | 0.24% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,300 | 645,000 | 0.22% | ||
| 46 | TEACHERS ADVISORS, LLC | 30,805 | 615,000 | 0.21% | ||
| 47 | DUPONT CAPITAL MANAGEMENT CORP | 26,995 | 539,000 | 0.19% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 22,683 | 452,000 | 0.16% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,084 | 441,000 | 0.15% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 17,879 | 357,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
