| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 5,012,815 | 50,279,000 | 18.92% | ||
| 2 | FMR LLC | 2,147,834 | 21,543,000 | 8.11% | ||
| 3 | VANGUARD GROUP INC | 2,062,674 | 20,689,000 | 7.78% | ||
| 4 | CANADA PENSION PLAN INVESTMENT BOARD | 1,976,220 | 19,821,000 | 7.46% | ||
| 5 | BlackRock Fund Advisors | 1,949,742 | 19,556,000 | 7.36% | ||
| 6 | GREAT POINT PARTNERS LLC | 1,940,000 | 19,458,000 | 7.32% | ||
| 7 | STATE STREET CORP | 1,369,560 | 13,729,000 | 5.17% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 916,927 | 9,197,000 | 3.46% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 783,777 | 7,861,000 | 2.96% | ||
| 10 | C WorldWide Group Holding A/S | 625,510 | 6,274,000 | 2.36% | ||
| 11 | Granahan Investment Management, LLC | 573,101 | 5,748,000 | 2.16% | ||
| 12 | NORTHERN TRUST CORP | 462,980 | 4,644,000 | 1.75% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 394,050 | 3,952,000 | 1.49% | ||
| 14 | BB BIOTECH AG | 366,203 | 3,673,000 | 1.38% | ||
| 15 | A.R.T. Advisors, LLC | 353,527 | 3,545,000 | 1.33% | ||
| 16 | NORGES BANK | 343,232 | 3,443,000 | 1.30% | ||
| 17 | Gruss Capital Management LP | 300,000 | 3,009,000 | 1.13% | ||
| 18 | HARVEY CAPITAL MANAGEMENT INC | 293,500 | 2,943,000 | 1.11% | ||
| 19 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 276,000 | 2,768,000 | 1.04% | ||
| 20 | GOLDMAN SACHS GROUP INC | 249,067 | 2,498,000 | 0.94% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 231,542 | 2,322,000 | 0.87% | ||
| 22 | Rhenman & Partners Asset Management AB | 225,000 | 2,257,000 | 0.85% | ||
| 23 | Candriam S.C.A. | 213,600 | 2,142,000 | 0.81% | ||
| 24 | Rock Springs Capital Management LP | 200,000 | 2,006,000 | 0.75% | ||
| 25 | Tekla Capital Management LLC | 192,322 | 1,929,000 | 0.73% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 181,136 | 1,817,000 | 0.68% | ||
| 27 | Bank of New York Mellon Corp | 162,039 | 1,626,000 | 0.61% | ||
| 28 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 155,459 | 1,559,000 | 0.59% | ||
| 29 | EVENTIDE ASSET MANAGEMENT, LLC | 139,300 | 1,397,000 | 0.53% | ||
| 30 | BlackRock Investment Management, LLC | 120,917 | 1,213,000 | 0.46% | ||
| 31 | DEUTSCHE BANK AG\ | 118,606 | 1,186,000 | 0.45% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 109,361 | 1,097,000 | 0.41% | ||
| 33 | TEACHERS ADVISORS, LLC | 101,923 | 1,022,000 | 0.38% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 96,800 | 971,000 | 0.37% | Put | |
| 35 | D. E. Shaw & Co., Inc. | 85,879 | 861,000 | 0.32% | ||
| 36 | OXFORD ASSET MANAGEMENT LLP | 82,668 | 836,000 | 0.31% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 77,344 | 776,000 | 0.29% | ||
| 38 | PUTNAM INVESTMENTS LLC | 75,000 | 752,000 | 0.28% | ||
| 39 | TWO SIGMA ADVISERS, LP | 74,500 | 747,000 | 0.28% | ||
| 40 | CREDIT SUISSE AG/ | 73,789 | 741,000 | 0.28% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,400 | 716,000 | 0.27% | Call | |
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 66,987 | 672,000 | 0.25% | ||
| 43 | DOW CHEMICAL CO /DE/ | 65,000 | 652,000 | 0.25% | ||
| 44 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 63,785 | 640,000 | 0.24% | ||
| 45 | MACQUARIE GROUP LTD | 62,725 | 629,000 | 0.24% | ||
| 46 | GABELLI FUNDS LLC | 50,000 | 502,000 | 0.19% | ||
| 47 | GROUP ONE TRADING LLC | 47,482 | 476,000 | 0.18% | ||
| 48 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 46,549 | 466,000 | 0.18% | ||
| 49 | HAP Trading, LLC | 39,329 | 394,000 | 0.15% | ||
| 50 | RHUMBLINE ADVISERS | 37,575 | 377,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
