| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 2,471,984 | 10,628,000 | 11.29% | ||
| 2 | GREAT POINT PARTNERS LLC | 2,299,529 | 9,888,000 | 10.51% | ||
| 3 | CANADA PENSION PLAN INVESTMENT BOARD | 1,976,220 | 8,498,000 | 9.03% | ||
| 4 | FMR LLC | 1,968,906 | 8,466,000 | 8.99% | ||
| 5 | BlackRock Fund Advisors | 1,432,702 | 6,161,000 | 6.55% | ||
| 6 | VANGUARD GROUP INC | 1,290,655 | 5,550,000 | 5.90% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 896,369 | 3,854,000 | 4.09% | ||
| 8 | RENAISSANCE TECHNOLOGIES LLC | 784,805 | 3,375,000 | 3.59% | ||
| 9 | STATE STREET CORP | 695,480 | 2,989,000 | 3.18% | ||
| 10 | Granahan Investment Management, LLC | 686,921 | 2,954,000 | 3.14% | ||
| 11 | NORTHERN TRUST CORP | 607,567 | 2,613,000 | 2.78% | ||
| 12 | EVENTIDE ASSET MANAGEMENT, LLC | 600,000 | 2,580,000 | 2.74% | ||
| 13 | ARMISTICE CAPITAL, LLC | 482,073 | 2,073,000 | 2.20% | ||
| 14 | Rock Springs Capital Management LP | 425,000 | 1,828,000 | 1.94% | ||
| 15 | Clearline Capital LP | 377,132 | 1,622,000 | 1.72% | ||
| 16 | Candriam S.C.A. | 374,000 | 1,608,000 | 1.71% | ||
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 361,717 | 1,555,000 | 1.65% | ||
| 18 | DEUTSCHE BANK AG\ | 316,061 | 1,358,000 | 1.44% | ||
| 19 | Rhenman & Partners Asset Management AB | 300,000 | 1,290,000 | 1.37% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 256,630 | 1,103,000 | 1.17% | ||
| 21 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 252,400 | 1,085,000 | 1.15% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 230,758 | 992,000 | 1.05% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 222,260 | 956,000 | 1.02% | ||
| 24 | Tekla Capital Management LLC | 192,322 | 827,000 | 0.88% | ||
| 25 | Bank of New York Mellon Corp | 171,552 | 738,000 | 0.78% | ||
| 26 | BlackRock Investment Management, LLC | 151,120 | 650,000 | 0.69% | ||
| 27 | GABELLI FUNDS LLC | 120,000 | 516,000 | 0.55% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 113,453 | 488,000 | 0.52% | ||
| 29 | DAFNA Capital Management LLC | 103,690 | 446,000 | 0.47% | ||
| 30 | FEDERATED HERMES, INC. | 93,303 | 401,000 | 0.43% | ||
| 31 | TWO SIGMA ADVISERS, LP | 93,000 | 400,000 | 0.42% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 76,320 | 328,000 | 0.35% | ||
| 33 | PUTNAM INVESTMENTS LLC | 75,000 | 322,000 | 0.34% | ||
| 34 | EMERALD ACQUISITION LTD. | 74,033 | 318,000 | 0.34% | ||
| 35 | GOLDMAN SACHS GROUP INC | 67,302 | 289,000 | 0.31% | ||
| 36 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 65,791 | 283,000 | 0.30% | ||
| 37 | DOW CHEMICAL CO /DE/ | 65,000 | 280,000 | 0.30% | ||
| 38 | FALCON POINT CAPITAL, LLC | 64,369 | 277,000 | 0.29% | ||
| 39 | GROUP ONE TRADING LLC | 60,277 | 259,000 | 0.28% | ||
| 40 | ACADIAN ASSET MANAGEMENT LLC | 59,986 | 257,000 | 0.27% | ||
| 41 | TEACHERS ADVISORS, LLC | 58,899 | 253,000 | 0.27% | ||
| 42 | RHUMBLINE ADVISERS | 57,435 | 247,000 | 0.26% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 55,400 | 238,000 | 0.25% | ||
| 44 | CREDIT SUISSE AG/ | 48,126 | 208,000 | 0.22% | ||
| 45 | NISA INVESTMENT ADVISORS, LLC | 43,500 | 187,000 | 0.20% | ||
| 46 | NORGES BANK | 38,160 | 164,000 | 0.17% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,600 | 153,000 | 0.16% | Put | |
| 48 | AQR CAPITAL MANAGEMENT LLC | 34,732 | 149,000 | 0.16% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 33,000 | 142,000 | 0.15% | ||
| 50 | ProShare Advisors LLC | 31,696 | 136,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
