| 1 |
TPG Group Holdings (SBS) Advisors, Inc. |
3,551,929 |
19,180,000 |
22.91% |
|
|
| 2 |
ACUTA CAPITAL PARTNERS, LLC |
2,736,642 |
14,778,000 |
17.65% |
|
|
| 3 |
EVENTIDE ASSET MANAGEMENT, LLC |
2,252,000 |
12,161,000 |
14.52% |
|
|
| 4 |
CLOUGH CAPITAL PARTNERS L P |
917,289 |
4,953,000 |
5.92% |
|
|
| 5 |
Avoro Capital Advisors LLC |
730,514 |
3,945,000 |
4.71% |
|
|
| 6 |
First Light Asset Management, LLC |
556,465 |
3,005,000 |
3.59% |
|
|
| 7 |
Grandeur Peak Global Advisors, LLC |
440,511 |
2,379,000 |
2.84% |
|
|
| 8 |
BlackRock Fund Advisors |
354,852 |
1,916,000 |
2.29% |
|
|
| 9 |
Ghost Tree Capital, LLC |
341,708 |
1,845,000 |
2.20% |
|
|
| 10 |
VANGUARD GROUP INC |
327,365 |
1,767,000 |
2.11% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
323,192 |
1,745,000 |
2.08% |
|
|
| 12 |
FEDERATED HERMES, INC. |
300,000 |
1,620,000 |
1.93% |
|
|
| 13 |
GENERAL ELECTRIC CO |
264,550 |
1,429,000 |
1.71% |
|
|
| 14 |
WALL STREET ASSOCIATES |
200,400 |
1,082,000 |
1.29% |
|
|
| 15 |
Consonance Capital Management LP |
165,825 |
895,000 |
1.07% |
|
|
| 16 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
165,097 |
892,000 |
1.07% |
|
|
| 17 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
151,000 |
815,000 |
0.97% |
|
|
| 18 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
148,600 |
802,000 |
0.96% |
|
|
| 19 |
STATE STREET CORP |
141,394 |
763,000 |
0.91% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
138,389 |
747,000 |
0.89% |
|
|
| 21 |
Cormorant Asset Management, LP |
137,990 |
745,000 |
0.89% |
|
|
| 22 |
NORTHERN TRUST CORP |
137,623 |
743,000 |
0.89% |
|
|
| 23 |
Broadfin Capital, LLC |
97,298 |
525,000 |
0.63% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
94,612 |
510,000 |
0.61% |
|
|
| 25 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
92,900 |
502,000 |
0.60% |
Put |
|
| 26 |
FORMULA GROWTH LTD |
64,785 |
350,000 |
0.42% |
|
|
| 27 |
Spark Investment Management LLC |
58,200 |
314,000 |
0.38% |
|
|
| 28 |
SIMPLEX TRADING, LLC |
55,986 |
302,000 |
0.36% |
|
|
| 29 |
Spot Trading L.L.C |
54,800 |
296,000 |
0.35% |
Put |
|
| 30 |
GROUP ONE TRADING LLC |
54,623 |
295,000 |
0.35% |
|
|
| 31 |
BlackRock Investment Management, LLC |
46,733 |
252,000 |
0.30% |
|
|
| 32 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
42,144 |
228,000 |
0.27% |
|
|
| 33 |
Bank of New York Mellon Corp |
41,851 |
226,000 |
0.27% |
|
|
| 34 |
RENAISSANCE TECHNOLOGIES LLC |
37,374 |
202,000 |
0.24% |
|
|
| 35 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
32,329 |
175,000 |
0.21% |
|
|
| 36 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
28,787 |
155,000 |
0.19% |
|
|
| 37 |
Clearbridge Investments, LLC |
24,748 |
134,000 |
0.16% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
23,200 |
126,000 |
0.15% |
|
|
| 39 |
DEUTSCHE BANK AG\ |
22,662 |
121,000 |
0.14% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
20,352 |
110,000 |
0.13% |
|
|
| 41 |
Spot Trading L.L.C |
17,500 |
95,000 |
0.11% |
|
|
| 42 |
DENVER INVESTMENT ADVISORS LLC |
17,303 |
93,000 |
0.11% |
|
|
| 43 |
KOPP INVESTMENT ADVISORS LLC |
14,115 |
76,000 |
0.09% |
|
|
| 44 |
RHUMBLINE ADVISERS |
12,553 |
68,000 |
0.08% |
|
|
| 45 |
CITIGROUP INC |
12,465 |
67,000 |
0.08% |
|
|
| 46 |
NEW YORK STATE COMMON RETIREMENT FUND |
12,300 |
66,000 |
0.08% |
|
|
| 47 |
MORGAN STANLEY |
10,185 |
55,000 |
0.07% |
|
|
| 48 |
Nationwide Fund Advisors |
8,588 |
46,000 |
0.05% |
|
|
| 49 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,896 |
43,000 |
0.05% |
|
|
| 50 |
UBS Group AG |
4,296 |
23,000 |
0.03% |
|
|
