| 1 |
TPG Group Holdings (SBS) Advisors, Inc. |
3,551,929 |
27,030,000 |
22.68% |
|
|
| 2 |
ACUTA CAPITAL PARTNERS, LLC |
3,144,649 |
23,931,000 |
20.08% |
|
|
| 3 |
EVENTIDE ASSET MANAGEMENT, LLC |
2,252,000 |
17,138,000 |
14.38% |
|
|
| 4 |
Avoro Capital Advisors LLC |
918,556 |
6,990,000 |
5.87% |
|
|
| 5 |
First Light Asset Management, LLC |
573,779 |
4,366,000 |
3.66% |
|
|
| 6 |
VANGUARD GROUP INC |
559,062 |
4,255,000 |
3.57% |
|
|
| 7 |
Grandeur Peak Global Advisors, LLC |
552,711 |
4,206,000 |
3.53% |
|
|
| 8 |
FEDERATED HERMES, INC. |
525,000 |
3,995,000 |
3.35% |
|
|
| 9 |
BlackRock Fund Advisors |
384,644 |
2,927,000 |
2.46% |
|
|
| 10 |
CANNELL CAPITAL LLC |
380,716 |
2,897,000 |
2.43% |
|
|
| 11 |
Ghost Tree Capital, LLC |
364,000 |
2,770,000 |
2.32% |
|
|
| 12 |
GENERAL ELECTRIC CO |
264,550 |
2,013,000 |
1.69% |
|
|
| 13 |
MILLENNIUM MANAGEMENT LLC |
249,493 |
1,899,000 |
1.59% |
|
|
| 14 |
WALL STREET ASSOCIATES |
200,400 |
1,525,000 |
1.28% |
|
|
| 15 |
NORTHERN TRUST CORP |
176,959 |
1,347,000 |
1.13% |
|
|
| 16 |
RENAISSANCE TECHNOLOGIES LLC |
171,774 |
1,307,000 |
1.10% |
|
|
| 17 |
Consonance Capital Management LP |
165,825 |
1,262,000 |
1.06% |
|
|
| 18 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
151,000 |
1,149,000 |
0.96% |
|
|
| 19 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
148,600 |
1,131,000 |
0.95% |
|
|
| 20 |
STATE STREET CORP |
148,007 |
1,127,000 |
0.95% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
140,935 |
1,073,000 |
0.90% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
98,163 |
747,000 |
0.63% |
|
|
| 23 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
51,000 |
388,000 |
0.33% |
Put |
|
| 24 |
BlackRock Investment Management, LLC |
50,259 |
382,000 |
0.32% |
|
|
| 25 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
45,797 |
349,000 |
0.29% |
|
|
| 26 |
Bank of New York Mellon Corp |
43,377 |
330,000 |
0.28% |
|
|
| 27 |
Birchview Capital, LP |
34,567 |
263,000 |
0.22% |
|
|
| 28 |
Spark Investment Management LLC |
33,000 |
251,000 |
0.21% |
|
|
| 29 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
29,687 |
226,000 |
0.19% |
|
|
| 30 |
ROYCE & ASSOCIATES LP |
27,000 |
205,000 |
0.17% |
|
|
| 31 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
23,493 |
179,000 |
0.15% |
|
|
| 32 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
23,200 |
177,000 |
0.15% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
22,707 |
172,000 |
0.14% |
|
|
| 34 |
TEACHERS ADVISORS, LLC |
17,773 |
135,000 |
0.11% |
|
|
| 35 |
DENVER INVESTMENT ADVISORS LLC |
14,323 |
109,000 |
0.09% |
|
|
| 36 |
STRS OHIO |
14,031 |
106,000 |
0.09% |
|
|
| 37 |
RHUMBLINE ADVISERS |
13,143 |
100,000 |
0.08% |
|
|
| 38 |
NEW YORK STATE COMMON RETIREMENT FUND |
12,300 |
94,000 |
0.08% |
|
|
| 39 |
ROYAL BANK OF CANADA |
10,000 |
76,000 |
0.06% |
|
|
| 40 |
MORGAN STANLEY |
9,247 |
70,000 |
0.06% |
|
|
| 41 |
Nationwide Fund Advisors |
8,588 |
65,000 |
0.05% |
|
|
| 42 |
WELLS FARGO & COMPANY/MN |
8,452 |
64,000 |
0.05% |
|
|
| 43 |
AMERICAN INTERNATIONAL GROUP, INC. |
8,074 |
61,443 |
0.05% |
|
|
| 44 |
JPMORGAN CHASE & CO |
6,638 |
51,000 |
0.04% |
|
|
| 45 |
CUTLER GROUP LLC / CA |
5,976 |
45,000 |
0.04% |
|
|
| 46 |
BLACKROCK ADVISORS LLC |
5,326 |
41,000 |
0.03% |
|
|
| 47 |
CITIGROUP INC |
4,150 |
32,000 |
0.03% |
|
|
| 48 |
GROUP ONE TRADING LLC |
3,004 |
23,000 |
0.02% |
|
|
| 49 |
SIMPLEX TRADING, LLC |
2,588 |
19,000 |
0.02% |
|
|
| 50 |
PANAGORA ASSET MANAGEMENT INC |
2,264 |
17,000 |
0.01% |
|
|
