| 1 |
TPG Group Holdings (SBS) Advisors, Inc. |
3,551,929 |
27,492,000 |
16.82% |
|
|
| 2 |
ACUTA CAPITAL PARTNERS, LLC |
3,513,161 |
27,192,000 |
16.64% |
|
|
| 3 |
EVENTIDE ASSET MANAGEMENT, LLC |
2,252,000 |
17,430,000 |
10.66% |
|
|
| 4 |
Broadfin Capital, LLC |
1,788,266 |
13,841,000 |
8.47% |
|
|
| 5 |
CANNELL CAPITAL LLC |
1,079,587 |
8,356,000 |
5.11% |
|
|
| 6 |
STONEPINE CAPITAL MANAGEMENT, LLC |
970,500 |
7,512,000 |
4.60% |
|
|
| 7 |
Avoro Capital Advisors LLC |
906,999 |
7,020,000 |
4.29% |
|
|
| 8 |
VANGUARD GROUP INC |
790,894 |
6,122,000 |
3.75% |
|
|
| 9 |
First Light Asset Management, LLC |
692,210 |
5,358,000 |
3.28% |
|
|
| 10 |
Grandeur Peak Global Advisors, LLC |
534,752 |
4,139,000 |
2.53% |
|
|
| 11 |
FEDERATED HERMES, INC. |
525,000 |
4,064,000 |
2.49% |
|
|
| 12 |
BlackRock Fund Advisors |
443,866 |
3,436,000 |
2.10% |
|
|
| 13 |
MILLENNIUM MANAGEMENT LLC |
404,127 |
3,128,000 |
1.91% |
|
|
| 14 |
ACUTA CAPITAL PARTNERS, LLC |
375,000 |
2,903,000 |
1.78% |
Call |
|
| 15 |
AXIOM INVESTORS LLC /DE |
287,137 |
2,222,000 |
1.36% |
|
|
| 16 |
RENAISSANCE TECHNOLOGIES LLC |
216,900 |
1,679,000 |
1.03% |
|
|
| 17 |
Ghost Tree Capital, LLC |
200,000 |
1,548,000 |
0.95% |
|
|
| 18 |
SABBY MANAGEMENT, LLC |
193,999 |
1,502,000 |
0.92% |
|
|
| 19 |
NORTHERN TRUST CORP |
183,980 |
1,425,000 |
0.87% |
|
|
| 20 |
STATE STREET CORP |
167,368 |
1,297,000 |
0.79% |
|
|
| 21 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
148,600 |
1,150,000 |
0.70% |
|
|
| 22 |
BlackRock Institutional Trust Company, N.A. |
142,872 |
1,106,000 |
0.68% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
114,372 |
885,000 |
0.54% |
|
|
| 24 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
110,000 |
851,000 |
0.52% |
|
|
| 25 |
Numeric Investors LLC |
101,370 |
785,000 |
0.48% |
|
|
| 26 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
99,629 |
771,000 |
0.47% |
|
|
| 27 |
OXFORD ASSET MANAGEMENT LLP |
98,751 |
764,000 |
0.47% |
|
|
| 28 |
WALL STREET ASSOCIATES |
91,661 |
709,000 |
0.43% |
|
|
| 29 |
Birchview Capital, LP |
79,767 |
617,000 |
0.38% |
|
|
| 30 |
DENVER INVESTMENT ADVISORS LLC |
61,515 |
476,000 |
0.29% |
|
|
| 31 |
SIMPLEX TRADING, LLC |
59,782 |
462,000 |
0.28% |
|
|
| 32 |
Bank of New York Mellon Corp |
59,517 |
461,000 |
0.28% |
|
|
| 33 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
58,179 |
450,000 |
0.28% |
|
|
| 34 |
BlackRock Investment Management, LLC |
51,150 |
396,000 |
0.24% |
|
|
| 35 |
Spark Investment Management LLC |
50,700 |
392,000 |
0.24% |
|
|
| 36 |
MORGAN STANLEY |
50,217 |
389,000 |
0.24% |
|
|
| 37 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
49,100 |
380,000 |
0.23% |
|
|
| 38 |
Consonance Capital Management LP |
46,752 |
362,000 |
0.22% |
|
|
| 39 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
46,800 |
362,000 |
0.22% |
Put |
|
| 40 |
ARK INVESTMENT MANAGEMENT LLC |
45,351 |
351,000 |
0.21% |
|
|
| 41 |
TWO SIGMA INVESTMENTS, LP |
36,880 |
285,000 |
0.17% |
|
|
| 42 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
34,187 |
265,000 |
0.16% |
|
|
| 43 |
Parallax Volatility Advisers, L.P. |
30,000 |
232,000 |
0.14% |
Put |
|
| 44 |
STRS OHIO |
29,500 |
228,000 |
0.14% |
|
|
| 45 |
JPMORGAN CHASE & CO |
23,579 |
183,000 |
0.11% |
|
|
| 46 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
23,200 |
180,000 |
0.11% |
|
|
| 47 |
Trexquant Investment LP |
20,765 |
161,000 |
0.10% |
|
|
| 48 |
GROUP ONE TRADING LLC |
19,529 |
151,000 |
0.09% |
|
|
| 49 |
CITADEL ADVISORS LLC |
18,187 |
141,000 |
0.09% |
|
|
| 50 |
TEACHERS ADVISORS, LLC |
17,773 |
138,000 |
0.08% |
|
|
