| 1 |
TPG Group Holdings (SBS) Advisors, Inc. |
3,551,929 |
17,866,000 |
22.83% |
|
|
| 2 |
ACUTA CAPITAL PARTNERS, LLC |
3,187,607 |
16,034,000 |
20.49% |
|
|
| 3 |
EVENTIDE ASSET MANAGEMENT, LLC |
2,252,000 |
11,328,000 |
14.47% |
|
|
| 4 |
Avoro Capital Advisors LLC |
918,556 |
4,620,000 |
5.90% |
|
|
| 5 |
Grandeur Peak Global Advisors, LLC |
566,636 |
2,850,000 |
3.64% |
|
|
| 6 |
First Light Asset Management, LLC |
546,021 |
2,746,000 |
3.51% |
|
|
| 7 |
VANGUARD GROUP INC |
526,438 |
2,648,000 |
3.38% |
|
|
| 8 |
BlackRock Fund Advisors |
361,743 |
1,820,000 |
2.33% |
|
|
| 9 |
Ghost Tree Capital, LLC |
341,708 |
1,719,000 |
2.20% |
|
|
| 10 |
FEDERATED HERMES, INC. |
300,000 |
1,509,000 |
1.93% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
276,859 |
1,393,000 |
1.78% |
|
|
| 12 |
CLOUGH CAPITAL PARTNERS L P |
267,547 |
1,346,000 |
1.72% |
|
|
| 13 |
GENERAL ELECTRIC CO |
264,550 |
1,331,000 |
1.70% |
|
|
| 14 |
WALL STREET ASSOCIATES |
200,400 |
1,008,000 |
1.29% |
|
|
| 15 |
STONEPINE CAPITAL MANAGEMENT, LLC |
186,926 |
940,000 |
1.20% |
|
|
| 16 |
Consonance Capital Management LP |
165,825 |
834,000 |
1.07% |
|
|
| 17 |
NORTHERN TRUST CORP |
152,210 |
765,000 |
0.98% |
|
|
| 18 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
151,000 |
760,000 |
0.97% |
|
|
| 19 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
148,600 |
748,000 |
0.96% |
|
|
| 20 |
STATE STREET CORP |
146,503 |
741,000 |
0.95% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
138,275 |
696,000 |
0.89% |
|
|
| 22 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
113,500 |
571,000 |
0.73% |
Put |
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
103,551 |
520,000 |
0.66% |
|
|
| 24 |
RENAISSANCE TECHNOLOGIES LLC |
66,800 |
336,000 |
0.43% |
|
|
| 25 |
SIMPLEX TRADING, LLC |
62,053 |
312,000 |
0.40% |
|
|
| 26 |
Spark Investment Management LLC |
59,100 |
297,000 |
0.38% |
|
|
| 27 |
BlackRock Investment Management, LLC |
47,453 |
239,000 |
0.31% |
|
|
| 28 |
Bank of New York Mellon Corp |
45,806 |
231,000 |
0.30% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
45,797 |
230,000 |
0.29% |
|
|
| 30 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
35,707 |
180,000 |
0.23% |
|
|
| 31 |
Spot Trading L.L.C |
34,800 |
175,000 |
0.22% |
Put |
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
29,387 |
148,000 |
0.19% |
|
|
| 33 |
ROYCE & ASSOCIATES LP |
27,000 |
136,000 |
0.17% |
|
|
| 34 |
GROUP ONE TRADING LLC |
23,530 |
118,000 |
0.15% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
23,200 |
117,000 |
0.15% |
|
|
| 36 |
KOPP INVESTMENT ADVISORS LLC |
21,975 |
111,000 |
0.14% |
|
|
| 37 |
Clearbridge Investments, LLC |
21,211 |
107,000 |
0.14% |
|
|
| 38 |
TEACHERS ADVISORS, LLC |
17,773 |
89,000 |
0.11% |
|
|
| 39 |
Spot Trading L.L.C |
15,900 |
80,000 |
0.10% |
|
|
| 40 |
DENVER INVESTMENT ADVISORS LLC |
14,743 |
74,000 |
0.09% |
|
|
| 41 |
RHUMBLINE ADVISERS |
13,003 |
65,000 |
0.08% |
|
|
| 42 |
NEW YORK STATE COMMON RETIREMENT FUND |
12,300 |
62,000 |
0.08% |
|
|
| 43 |
GOLDMAN SACHS GROUP INC |
10,970 |
55,000 |
0.07% |
|
|
| 44 |
Nationwide Fund Advisors |
8,588 |
43,000 |
0.05% |
|
|
| 45 |
WELLS FARGO & COMPANY/MN |
8,452 |
43,000 |
0.05% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
8,062 |
40,552 |
0.05% |
|
|
| 47 |
MORGAN STANLEY |
6,785 |
34,000 |
0.04% |
|
|
| 48 |
DEUTSCHE BANK AG\ |
5,141 |
25,000 |
0.03% |
|
|
| 49 |
CUTLER GROUP LLC / CA |
4,968 |
24,000 |
0.03% |
|
|
| 50 |
UBS Group AG |
4,637 |
23,000 |
0.03% |
|
|
