| 1 |
TPG Group Holdings (SBS) Advisors, Inc. |
3,551,929 |
39,568,000 |
23.00% |
|
|
| 2 |
EVENTIDE ASSET MANAGEMENT, LLC |
2,051,498 |
22,854,000 |
13.28% |
|
|
| 3 |
CLOUGH CAPITAL PARTNERS L P |
1,440,036 |
16,042,000 |
9.32% |
|
|
| 4 |
Camber Capital Management LP |
1,226,994 |
13,669,000 |
7.94% |
|
|
| 5 |
ACUTA CAPITAL PARTNERS, LLC |
798,100 |
8,891,000 |
5.17% |
|
|
| 6 |
Avoro Capital Advisors LLC |
758,497 |
8,450,000 |
4.91% |
|
|
| 7 |
Broadfin Capital, LLC |
736,196 |
8,201,000 |
4.77% |
|
|
| 8 |
First Light Asset Management, LLC |
482,263 |
5,372,000 |
3.12% |
|
|
| 9 |
Polar Asset Management Partners Inc. |
429,447 |
4,784,000 |
2.78% |
|
|
| 10 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
383,256 |
4,269,000 |
2.48% |
|
|
| 11 |
WALL STREET ASSOCIATES |
354,700 |
3,951,000 |
2.30% |
|
|
| 12 |
BlackRock Fund Advisors |
351,435 |
3,915,000 |
2.28% |
|
|
| 13 |
Consonance Capital Management LP |
298,966 |
3,330,000 |
1.94% |
|
|
| 14 |
GENERAL ELECTRIC CO |
264,550 |
2,947,000 |
1.71% |
|
|
| 15 |
Grandeur Peak Global Advisors, LLC |
219,879 |
2,449,000 |
1.42% |
|
|
| 16 |
VANGUARD GROUP INC |
202,305 |
2,253,000 |
1.31% |
|
|
| 17 |
MILLENNIUM MANAGEMENT LLC |
197,628 |
2,202,000 |
1.28% |
|
|
| 18 |
FEDERATED HERMES, INC. |
176,400 |
1,965,000 |
1.14% |
|
|
| 19 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
148,600 |
1,655,000 |
0.96% |
|
|
| 20 |
Informed Momentum Co LLC |
148,324 |
1,652,000 |
0.96% |
|
|
| 21 |
Cormorant Asset Management, LP |
137,990 |
1,537,000 |
0.89% |
|
|
| 22 |
GILDER GAGNON HOWE & CO LLC |
126,852 |
1,413,000 |
0.82% |
|
|
| 23 |
BlackRock Institutional Trust Company, N.A. |
107,171 |
1,070,000 |
0.62% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
87,131 |
970,000 |
0.56% |
|
|
| 25 |
Ghost Tree Capital, LLC |
78,386 |
873,000 |
0.51% |
|
|
| 26 |
NORTHERN TRUST CORP |
76,646 |
854,000 |
0.50% |
|
|
| 27 |
I.G. INVESTMENT MANAGEMENT, LTD. |
74,395 |
829,000 |
0.48% |
|
|
| 28 |
STATE STREET CORP |
64,432 |
716,000 |
0.42% |
|
|
| 29 |
Bank of New York Mellon Corp |
46,963 |
523,000 |
0.30% |
|
|
| 30 |
BlackRock Investment Management, LLC |
46,339 |
516,000 |
0.30% |
|
|
| 31 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
41,000 |
457,000 |
0.27% |
|
|
| 32 |
KOPP INVESTMENT ADVISORS LLC |
39,085 |
435,000 |
0.25% |
|
|
| 33 |
GOLDMAN SACHS GROUP INC |
39,028 |
435,000 |
0.25% |
|
|
| 34 |
BOSTON ADVISORS LLC |
32,975 |
367,000 |
0.21% |
|
|
| 35 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
32,329 |
360,000 |
0.21% |
|
|
| 36 |
BLAIR WILLIAM & CO/IL |
28,945 |
322,000 |
0.19% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
24,623 |
274,000 |
0.16% |
|
|
| 38 |
MORGAN STANLEY |
22,226 |
248,000 |
0.14% |
|
|
| 39 |
Clearbridge Investments, LLC |
16,501 |
184,000 |
0.11% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
16,505 |
184,000 |
0.11% |
|
|
| 41 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
15,500 |
173,000 |
0.10% |
|
|
| 42 |
NEW YORK STATE COMMON RETIREMENT FUND |
11,400 |
127,000 |
0.07% |
|
|
| 43 |
RHUMBLINE ADVISERS |
10,845 |
121,000 |
0.07% |
|
|
| 44 |
DEUTSCHE BANK AG\ |
10,440 |
116,000 |
0.07% |
|
|
| 45 |
CREDIT SUISSE AG/ |
10,359 |
115,000 |
0.07% |
|
|
| 46 |
Nationwide Fund Advisors |
8,588 |
96,000 |
0.06% |
|
|
| 47 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,901 |
88,017 |
0.05% |
|
|
| 48 |
BLACKROCK ADVISORS LLC |
6,683 |
74,000 |
0.04% |
|
|
| 49 |
UBS Group AG |
3,045 |
34,000 |
0.02% |
|
|
| 50 |
ROYAL BANK OF CANADA |
2,484 |
28,000 |
0.02% |
|
|
