| 1 |
TPG Group Holdings (SBS) Advisors, Inc. |
3,551,929 |
25,574,000 |
23.30% |
|
|
| 2 |
EVENTIDE ASSET MANAGEMENT, LLC |
2,252,000 |
16,214,000 |
14.77% |
|
|
| 3 |
ACUTA CAPITAL PARTNERS, LLC |
1,716,000 |
12,355,000 |
11.25% |
|
|
| 4 |
CLOUGH CAPITAL PARTNERS L P |
1,061,354 |
7,642,000 |
6.96% |
|
|
| 5 |
Avoro Capital Advisors LLC |
741,353 |
5,338,000 |
4.86% |
|
|
| 6 |
First Light Asset Management, LLC |
532,574 |
3,835,000 |
3.49% |
|
|
| 7 |
MILLENNIUM MANAGEMENT LLC |
466,830 |
3,361,000 |
3.06% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
392,147 |
2,823,000 |
2.57% |
|
|
| 9 |
Grandeur Peak Global Advisors, LLC |
385,736 |
2,777,000 |
2.53% |
|
|
| 10 |
BlackRock Fund Advisors |
357,319 |
2,573,000 |
2.34% |
|
|
| 11 |
Ghost Tree Capital, LLC |
350,000 |
2,520,000 |
2.30% |
|
|
| 12 |
FEDERATED HERMES, INC. |
320,000 |
2,304,000 |
2.10% |
|
|
| 13 |
Broadfin Capital, LLC |
304,980 |
2,196,000 |
2.00% |
|
|
| 14 |
VANGUARD GROUP INC |
292,331 |
2,105,000 |
1.92% |
|
|
| 15 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
282,217 |
2,032,000 |
1.85% |
|
|
| 16 |
GENERAL ELECTRIC CO |
264,550 |
1,905,000 |
1.74% |
|
|
| 17 |
WALL STREET ASSOCIATES |
200,400 |
1,443,000 |
1.31% |
|
|
| 18 |
Consonance Capital Management LP |
165,825 |
1,194,000 |
1.09% |
|
|
| 19 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
148,600 |
1,070,000 |
0.97% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
141,385 |
1,018,000 |
0.93% |
|
|
| 21 |
Cormorant Asset Management, LP |
137,990 |
994,000 |
0.91% |
|
|
| 22 |
NORTHERN TRUST CORP |
137,445 |
990,000 |
0.90% |
|
|
| 23 |
STATE STREET CORP |
98,342 |
709,000 |
0.65% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
90,611 |
652,000 |
0.59% |
|
|
| 25 |
GILDER GAGNON HOWE & CO LLC |
79,319 |
571,000 |
0.52% |
|
|
| 26 |
FORMULA GROWTH LTD |
68,486 |
493,000 |
0.45% |
|
|
| 27 |
Granite Investment Partners, LLC |
64,177 |
462,000 |
0.42% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
63,084 |
454,000 |
0.41% |
|
|
| 29 |
Spark Investment Management LLC |
59,200 |
426,000 |
0.39% |
|
|
| 30 |
BlackRock Investment Management, LLC |
45,913 |
331,000 |
0.30% |
|
|
| 31 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
43,500 |
313,000 |
0.29% |
|
|
| 32 |
Bank of New York Mellon Corp |
41,851 |
301,000 |
0.27% |
|
|
| 33 |
Bluefin Trading, LLC |
35,000 |
252,000 |
0.23% |
|
|
| 34 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
32,329 |
233,000 |
0.21% |
|
|
| 35 |
BLAIR WILLIAM & CO/IL |
27,105 |
195,000 |
0.18% |
|
|
| 36 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
25,012 |
180,000 |
0.16% |
|
|
| 37 |
RTW INVESTMENTS, LP |
25,000 |
180,000 |
0.16% |
|
|
| 38 |
Clearbridge Investments, LLC |
24,748 |
178,000 |
0.16% |
|
|
| 39 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
23,200 |
168,000 |
0.15% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
20,352 |
147,000 |
0.13% |
|
|
| 41 |
RENAISSANCE TECHNOLOGIES LLC |
17,719 |
128,000 |
0.12% |
|
|
| 42 |
DENVER INVESTMENT ADVISORS LLC |
16,099 |
116,000 |
0.11% |
|
|
| 43 |
CITADEL ADVISORS LLC |
15,380 |
111,000 |
0.10% |
|
|
| 44 |
KOPP INVESTMENT ADVISORS LLC |
14,250 |
103,000 |
0.09% |
|
|
| 45 |
DEUTSCHE BANK AG\ |
13,509 |
96,000 |
0.09% |
|
|
| 46 |
GROUP ONE TRADING LLC |
13,170 |
95,000 |
0.09% |
|
|
| 47 |
NOMURA HOLDINGS INC |
13,000 |
94,000 |
0.09% |
|
|
| 48 |
RHUMBLINE ADVISERS |
12,553 |
90,000 |
0.08% |
|
|
| 49 |
NEW YORK STATE COMMON RETIREMENT FUND |
12,300 |
89,000 |
0.08% |
|
|
| 50 |
MORGAN STANLEY |
10,368 |
75,000 |
0.07% |
|
|
