| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 23,071,472 | 97,131,000 | 29.60% | ||
| 2 | FMR LLC | 16,061,576 | 67,619,000 | 20.61% | ||
| 3 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,761,311 | 15,835,000 | 4.83% | ||
| 4 | BlackRock Fund Advisors | 3,319,529 | 13,975,000 | 4.26% | ||
| 5 | VANGUARD GROUP INC | 3,244,783 | 13,660,000 | 4.16% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 2,684,466 | 11,302,000 | 3.44% | ||
| 7 | ORBIMED ADVISORS LLC | 2,437,000 | 10,260,000 | 3.13% | ||
| 8 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,835,900 | 7,729,000 | 2.36% | ||
| 9 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1,646,401 | 6,931,000 | 2.11% | ||
| 10 | STATE STREET CORP | 1,215,952 | 5,117,000 | 1.56% | ||
| 11 | Artal Group S.A. | 1,000,000 | 4,210,000 | 1.28% | ||
| 12 | HealthCor Management, L.P. | 1,000,000 | 4,210,000 | 1.28% | Call | |
| 13 | NORTHERN TRUST CORP | 922,228 | 3,883,000 | 1.18% | ||
| 14 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 910,000 | 3,831,000 | 1.17% | Call | |
| 15 | D. E. Shaw & Co., Inc. | 864,186 | 3,638,000 | 1.11% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 808,800 | 3,405,000 | 1.04% | Put | |
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 806,100 | 3,394,000 | 1.03% | Call | |
| 18 | Artal Group S.A. | 800,000 | 3,368,000 | 1.03% | Call | |
| 19 | MORGAN STANLEY | 794,015 | 3,343,000 | 1.02% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 700,887 | 2,951,000 | 0.90% | ||
| 21 | Palo Alto Investors LP | 624,900 | 2,631,000 | 0.80% | ||
| 22 | JPMORGAN CHASE & CO | 600,865 | 2,530,000 | 0.77% | ||
| 23 | BLACKROCK ADVISORS LLC | 549,443 | 2,313,000 | 0.70% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 513,113 | 2,160,000 | 0.66% | ||
| 25 | SABBY MANAGEMENT, LLC | 434,318 | 1,828,000 | 0.56% | ||
| 26 | Bank of New York Mellon Corp | 423,073 | 1,781,000 | 0.54% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 404,162 | 1,700,000 | 0.52% | ||
| 28 | COLUMBUS CIRCLE INVESTORS | 338,804 | 1,426,000 | 0.43% | ||
| 29 | SMITH ASSET MANAGEMENT GROUP LP | 335,280 | 1,412,000 | 0.43% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 322,023 | 1,356,000 | 0.41% | ||
| 31 | MARSHALL WACE, LLP | 316,497 | 1,332,000 | 0.41% | ||
| 32 | BARCLAYS PLC | 329,919 | 1,320,000 | 0.40% | ||
| 33 | GUGGENHEIM CAPITAL LLC | 297,901 | 1,254,000 | 0.38% | ||
| 34 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 273,600 | 1,152,000 | 0.35% | ||
| 35 | BlackRock Investment Management, LLC | 252,804 | 1,064,000 | 0.32% | ||
| 36 | Nationwide Fund Advisors | 215,553 | 907,000 | 0.28% | ||
| 37 | PANAGORA ASSET MANAGEMENT INC | 212,660 | 895,000 | 0.27% | ||
| 38 | OXFORD ASSET MANAGEMENT LLP | 196,885 | 837,000 | 0.26% | ||
| 39 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 190,000 | 800,000 | 0.24% | ||
| 40 | GROUP ONE TRADING LLC | 188,776 | 795,000 | 0.24% | ||
| 41 | Weiss Multi-Strategy Advisers LLC | 180,000 | 758,000 | 0.23% | ||
| 42 | EVENTIDE ASSET MANAGEMENT, LLC | 177,200 | 746,000 | 0.23% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 164,392 | 693,000 | 0.21% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 154,794 | 652,000 | 0.20% | ||
| 45 | AMERICAN INTERNATIONAL GROUP, INC. | 153,067 | 644,412 | 0.20% | ||
| 46 | HealthCor Management, L.P. | 152,000 | 640,000 | 0.20% | ||
| 47 | ROYAL BANK OF CANADA | 136,086 | 574,000 | 0.17% | ||
| 48 | Swiss National Bank | 127,900 | 538,000 | 0.16% | ||
| 49 | DEUTSCHE BANK AG\ | 123,264 | 518,000 | 0.16% | ||
| 50 | TEACHERS ADVISORS, LLC | 117,454 | 494,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
