| 1 |
FMR LLC |
15,421,927 |
56,136,000 |
19.39% |
|
|
| 2 |
BAKER BROS. ADVISORS LP |
14,708,613 |
53,539,000 |
18.49% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
7,572,055 |
27,562,000 |
9.52% |
|
|
| 4 |
STATE STREET CORP |
7,175,879 |
26,120,000 |
9.02% |
|
|
| 5 |
BlackRock Fund Advisors |
3,993,208 |
14,535,000 |
5.02% |
|
|
| 6 |
VANGUARD GROUP INC |
3,315,771 |
12,070,000 |
4.17% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
2,764,021 |
10,061,000 |
3.47% |
|
|
| 8 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
2,240,900 |
8,157,000 |
2.82% |
|
|
| 9 |
D. E. Shaw & Co., Inc. |
1,946,769 |
7,086,000 |
2.45% |
|
|
| 10 |
MARSHALL WACE, LLP |
1,766,594 |
6,430,000 |
2.22% |
|
|
| 11 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
1,627,381 |
5,924,000 |
2.05% |
|
|
| 12 |
Broadfin Capital, LLC |
1,500,000 |
5,460,000 |
1.89% |
|
|
| 13 |
Artal Group S.A. |
1,200,000 |
4,368,000 |
1.51% |
|
|
| 14 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
1,051,800 |
3,829,000 |
1.32% |
Call |
|
| 15 |
MILLENNIUM MANAGEMENT LLC |
1,011,723 |
3,683,000 |
1.27% |
|
|
| 16 |
NORTHERN TRUST CORP |
963,230 |
3,506,000 |
1.21% |
|
|
| 17 |
Palo Alto Investors LP |
794,500 |
2,892,000 |
1.00% |
|
|
| 18 |
JPMORGAN CHASE & CO |
770,471 |
2,805,000 |
0.97% |
|
|
| 19 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
622,600 |
2,266,000 |
0.78% |
Put |
|
| 20 |
COLUMBUS CIRCLE INVESTORS |
608,421 |
2,215,000 |
0.77% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
575,886 |
2,096,000 |
0.72% |
|
|
| 22 |
Bank of New York Mellon Corp |
517,765 |
1,885,000 |
0.65% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
510,868 |
1,859,000 |
0.64% |
|
|
| 24 |
Quantitative Systematic Strategies LLC |
488,771 |
1,823,000 |
0.63% |
|
|
| 25 |
CITADEL ADVISORS LLC |
452,171 |
1,646,000 |
0.57% |
|
|
| 26 |
BELLEVUE ASSET MANAGEMENT AG |
295,000 |
1,074,000 |
0.37% |
|
|
| 27 |
MORGAN STANLEY |
285,181 |
1,038,000 |
0.36% |
|
|
| 28 |
SMITH ASSET MANAGEMENT GROUP LP |
283,160 |
1,031,000 |
0.36% |
|
|
| 29 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
273,600 |
1,010,000 |
0.35% |
|
|
| 30 |
BlackRock Investment Management, LLC |
269,602 |
981,000 |
0.34% |
|
|
| 31 |
AMERICAN INTERNATIONAL GROUP, INC. |
246,286 |
896,481 |
0.31% |
|
|
| 32 |
PANAGORA ASSET MANAGEMENT INC |
235,169 |
856,000 |
0.30% |
|
|
| 33 |
Connor, Clark & Lunn Investment Management Ltd. |
222,700 |
811,000 |
0.28% |
|
|
| 34 |
Granite Point Capital Management, L.P. |
200,000 |
728,000 |
0.25% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
199,709 |
727,000 |
0.25% |
|
|
| 36 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
190,000 |
692,000 |
0.24% |
|
|
| 37 |
Nationwide Fund Advisors |
178,439 |
650,000 |
0.22% |
|
|
| 38 |
EVENTIDE ASSET MANAGEMENT, LLC |
177,200 |
645,000 |
0.22% |
|
|
| 39 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
165,356 |
602,000 |
0.21% |
|
|
| 40 |
WEDBUSH SECURITIES INC |
148,650 |
541,000 |
0.19% |
|
|
| 41 |
Weiss Multi-Strategy Advisers LLC |
148,400 |
540,000 |
0.19% |
|
|
| 42 |
CREDIT SUISSE AG/ |
147,852 |
538,000 |
0.19% |
|
|
| 43 |
ROYAL BANK OF CANADA |
144,847 |
528,000 |
0.18% |
|
|
| 44 |
Swiss National Bank |
136,900 |
498,000 |
0.17% |
|
|
| 45 |
TEACHERS ADVISORS, LLC |
131,305 |
478,000 |
0.17% |
|
|
| 46 |
Nine Chapters Capital Management LLC |
118,900 |
433,000 |
0.15% |
|
|
| 47 |
GOLDMAN SACHS GROUP INC |
113,141 |
412,000 |
0.14% |
|
|
| 48 |
ProShare Advisors LLC |
110,874 |
404,000 |
0.14% |
|
|
| 49 |
RHUMBLINE ADVISERS |
103,933 |
378,000 |
0.13% |
|
|
| 50 |
ALLIANCEBERNSTEIN L.P. |
98,500 |
359,000 |
0.12% |
|
|
