| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 15,278,181 | 59,279,000 | 16.60% | ||
| 2 | BAKER BROS. ADVISORS LP | 14,683,513 | 56,972,000 | 15.95% | ||
| 3 | STATE STREET CORP | 8,250,057 | 32,008,000 | 8.96% | ||
| 4 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 7,000,000 | 27,160,000 | 7.61% | Call | |
| 5 | BlackRock Fund Advisors | 3,945,512 | 15,309,000 | 4.29% | ||
| 6 | VANGUARD GROUP INC | 3,427,171 | 13,297,000 | 3.72% | ||
| 7 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,273,120 | 12,700,000 | 3.56% | ||
| 8 | D. E. Shaw & Co., Inc. | 2,792,693 | 10,836,000 | 3.03% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,663,582 | 10,335,000 | 2.89% | ||
| 10 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,260,400 | 8,770,000 | 2.46% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 2,127,000 | 8,253,000 | 2.31% | Call | |
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,896,300 | 7,358,000 | 2.06% | Put | |
| 13 | Broadfin Capital, LLC | 1,500,000 | 5,820,000 | 1.63% | ||
| 14 | Artal Group S.A. | 1,200,000 | 4,656,000 | 1.30% | ||
| 15 | MARSHALL WACE, LLP | 1,134,205 | 4,401,000 | 1.23% | ||
| 16 | Signpost Capital Advisors, LP | 1,014,500 | 3,936,000 | 1.10% | ||
| 17 | NORTHERN TRUST CORP | 944,404 | 3,664,000 | 1.03% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 928,870 | 3,604,000 | 1.01% | ||
| 19 | HAP Trading, LLC | 905,039 | 3,512,000 | 0.98% | ||
| 20 | Jefferies Group LLC | 867,400 | 3,366,000 | 0.94% | ||
| 21 | Palo Alto Investors LP | 799,000 | 3,100,000 | 0.87% | ||
| 22 | JPMORGAN CHASE & CO | 763,921 | 2,964,000 | 0.83% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 737,600 | 2,862,000 | 0.80% | Put | |
| 24 | RENAISSANCE TECHNOLOGIES LLC | 665,511 | 2,582,000 | 0.72% | ||
| 25 | Opaleye Management Inc. | 650,000 | 2,522,000 | 0.71% | ||
| 26 | GOLDMAN SACHS GROUP INC | 588,972 | 2,285,000 | 0.64% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 519,132 | 2,014,000 | 0.56% | ||
| 28 | Bank of New York Mellon Corp | 497,485 | 1,931,000 | 0.54% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 449,521 | 1,744,000 | 0.49% | ||
| 30 | CREDIT SUISSE AG/ | 411,786 | 1,597,000 | 0.45% | ||
| 31 | MACQUARIE GROUP LTD | 404,200 | 1,568,000 | 0.44% | ||
| 32 | Artal Group S.A. | 400,000 | 1,552,000 | 0.43% | Call | |
| 33 | BARCLAYS PLC | 509,653 | 1,529,000 | 0.43% | ||
| 34 | COLUMBUS CIRCLE INVESTORS | 387,532 | 1,504,000 | 0.42% | ||
| 35 | BlackRock Investment Management, LLC | 333,999 | 1,296,000 | 0.36% | ||
| 36 | Laurion Capital Management LP | 326,700 | 1,268,000 | 0.36% | ||
| 37 | DEUTSCHE BANK AG\ | 311,523 | 1,207,000 | 0.34% | ||
| 38 | BELLEVUE ASSET MANAGEMENT AG | 295,000 | 1,145,000 | 0.32% | ||
| 39 | SMITH ASSET MANAGEMENT GROUP LP | 288,730 | 1,120,000 | 0.31% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 273,600 | 1,062,000 | 0.30% | ||
| 41 | WEDBUSH SECURITIES INC | 271,920 | 1,055,000 | 0.30% | ||
| 42 | GROUP ONE TRADING LLC | 256,914 | 997,000 | 0.28% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 252,069 | 978,028 | 0.27% | ||
| 44 | Quantitative Systematic Strategies LLC | 261,120 | 956,000 | 0.27% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 243,989 | 947,000 | 0.27% | ||
| 46 | Jefferies Group LLC | 227,900 | 884,000 | 0.25% | Call | |
| 47 | GOLDMAN SACHS GROUP INC | 190,300 | 738,000 | 0.21% | Put | |
| 48 | BARCLAYS PLC | 228,500 | 686,000 | 0.19% | Put | |
| 49 | Granite Point Capital Management, L.P. | 175,360 | 680,000 | 0.19% | ||
| 50 | GOLDMAN SACHS GROUP INC | 170,000 | 660,000 | 0.18% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
