| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 23,057,572 | 120,130,000 | 27.30% | ||
| 2 | FMR LLC | 15,984,996 | 83,281,000 | 18.93% | ||
| 3 | STATE STREET CORP | 4,149,666 | 21,619,000 | 4.91% | ||
| 4 | BlackRock Fund Advisors | 3,437,073 | 17,907,000 | 4.07% | ||
| 5 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,396,913 | 17,698,000 | 4.02% | ||
| 6 | DRIEHAUS CAPITAL MANAGEMENT LLC | 2,740,336 | 14,277,000 | 3.24% | ||
| 7 | ORBIMED ADVISORS LLC | 2,437,000 | 12,697,000 | 2.89% | ||
| 8 | VANGUARD GROUP INC | 2,405,212 | 12,531,000 | 2.85% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,358,865 | 12,290,000 | 2.79% | ||
| 10 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,045,077 | 10,655,000 | 2.42% | ||
| 11 | Redmile Group, LLC | 1,522,543 | 7,932,000 | 1.80% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 1,495,881 | 7,794,000 | 1.77% | ||
| 13 | MARSHALL WACE, LLP | 1,182,053 | 6,158,000 | 1.40% | ||
| 14 | Artal Group S.A. | 1,000,000 | 5,210,000 | 1.18% | ||
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,000,000 | 5,210,000 | 1.18% | Call | |
| 16 | NORTHERN TRUST CORP | 984,970 | 5,131,000 | 1.17% | ||
| 17 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 850,000 | 4,429,000 | 1.01% | Call | |
| 18 | BARCLAYS PLC | 881,700 | 4,409,000 | 1.00% | Put | |
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 669,251 | 3,487,000 | 0.79% | ||
| 20 | BLACKROCK ADVISORS LLC | 659,773 | 3,437,000 | 0.78% | ||
| 21 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 645,635 | 3,363,000 | 0.76% | ||
| 22 | MORGAN STANLEY | 614,603 | 3,202,000 | 0.73% | ||
| 23 | WELLINGTON MANAGEMENT GROUP LLP | 560,267 | 2,919,000 | 0.66% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 479,464 | 2,497,000 | 0.57% | ||
| 25 | GUGGENHEIM CAPITAL LLC | 469,967 | 2,448,000 | 0.56% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 421,100 | 2,194,000 | 0.50% | Call | |
| 27 | Forward Management, LLC | 304,931 | 1,907,000 | 0.43% | ||
| 28 | CITADEL ADVISORS LLC | 343,490 | 1,789,000 | 0.41% | ||
| 29 | Bank of New York Mellon Corp | 333,473 | 1,738,000 | 0.39% | ||
| 30 | BARCLAYS PLC | 337,519 | 1,688,000 | 0.38% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 275,900 | 1,437,000 | 0.33% | Put | |
| 32 | DEUTSCHE BANK AG\ | 262,764 | 1,368,000 | 0.31% | ||
| 33 | Numeric Investors LLC | 259,600 | 1,353,000 | 0.31% | ||
| 34 | EVENTIDE ASSET MANAGEMENT, LLC | 257,200 | 1,340,000 | 0.30% | ||
| 35 | Palo Alto Investors LP | 256,100 | 1,334,000 | 0.30% | ||
| 36 | D. E. Shaw & Co., Inc. | 247,143 | 1,288,000 | 0.29% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 273,600 | 1,277,000 | 0.29% | ||
| 38 | GOLDMAN SACHS GROUP INC | 240,000 | 1,250,000 | 0.28% | Call | |
| 39 | GOLDMAN SACHS GROUP INC | 240,000 | 1,250,000 | 0.28% | Put | |
| 40 | Weiss Multi-Strategy Advisers LLC | 222,350 | 1,158,000 | 0.26% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 221,967 | 1,157,000 | 0.26% | ||
| 42 | BlackRock Investment Management, LLC | 220,328 | 1,148,000 | 0.26% | ||
| 43 | GOLDMAN SACHS GROUP INC | 207,715 | 1,082,000 | 0.25% | ||
| 44 | GLG Partners LP | 206,995 | 1,078,000 | 0.24% | ||
| 45 | COLUMBUS CIRCLE INVESTORS | 194,011 | 1,011,000 | 0.23% | ||
| 46 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 194,000 | 1,011,000 | 0.23% | ||
| 47 | GROUP ONE TRADING LLC | 193,164 | 1,006,000 | 0.23% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 187,176 | 976,000 | 0.22% | ||
| 49 | CREDIT SUISSE AG/ | 185,020 | 964,000 | 0.22% | ||
| 50 | Connor, Clark & Lunn Investment Management Ltd. | 164,000 | 943,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
