| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 23,065,972 | 105,873,000 | 29.92% | ||
| 2 | FMR LLC | 16,034,809 | 73,600,000 | 20.80% | ||
| 3 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,548,313 | 16,251,000 | 4.59% | ||
| 4 | BlackRock Fund Advisors | 3,347,899 | 15,367,000 | 4.34% | ||
| 5 | VANGUARD GROUP INC | 3,079,289 | 14,134,000 | 3.99% | ||
| 6 | ORBIMED ADVISORS LLC | 2,437,000 | 11,186,000 | 3.16% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 2,433,280 | 11,169,000 | 3.16% | ||
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 2,314,541 | 10,624,000 | 3.00% | ||
| 9 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,006,690 | 9,210,000 | 2.60% | ||
| 10 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,500,000 | 6,885,000 | 1.95% | Call | |
| 11 | STATE STREET CORP | 1,201,243 | 5,513,000 | 1.56% | ||
| 12 | Artal Group S.A. | 1,000,000 | 4,590,000 | 1.30% | ||
| 13 | NORTHERN TRUST CORP | 910,512 | 4,179,000 | 1.18% | ||
| 14 | Artal Group S.A. | 800,000 | 3,672,000 | 1.04% | Call | |
| 15 | MORGAN STANLEY | 794,860 | 3,649,000 | 1.03% | ||
| 16 | TIAA CREF INVESTMENT MANAGEMENT LLC | 710,013 | 3,259,000 | 0.92% | ||
| 17 | Palo Alto Investors LP | 624,900 | 2,868,000 | 0.81% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 610,400 | 2,802,000 | 0.79% | Call | |
| 19 | JPMORGAN CHASE & CO | 608,244 | 2,792,000 | 0.79% | ||
| 20 | BLACKROCK ADVISORS LLC | 582,816 | 2,675,000 | 0.76% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 472,178 | 2,167,000 | 0.61% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 466,800 | 2,143,000 | 0.61% | Put | |
| 23 | MARSHALL WACE, LLP | 435,865 | 2,001,000 | 0.57% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 388,208 | 1,781,000 | 0.50% | ||
| 25 | BARCLAYS PLC | 407,872 | 1,633,000 | 0.46% | ||
| 26 | Bank of New York Mellon Corp | 355,111 | 1,630,000 | 0.46% | ||
| 27 | GOLDMAN SACHS GROUP INC | 340,003 | 1,561,000 | 0.44% | ||
| 28 | SMITH ASSET MANAGEMENT GROUP LP | 336,440 | 1,544,000 | 0.44% | ||
| 29 | GUGGENHEIM CAPITAL LLC | 302,121 | 1,387,000 | 0.39% | ||
| 30 | SABBY MANAGEMENT, LLC | 282,594 | 1,297,000 | 0.37% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 275,341 | 1,264,000 | 0.36% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 273,600 | 1,256,000 | 0.35% | ||
| 33 | COLUMBUS CIRCLE INVESTORS | 247,292 | 1,135,000 | 0.32% | ||
| 34 | BlackRock Investment Management, LLC | 247,357 | 1,135,000 | 0.32% | ||
| 35 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 241,500 | 1,108,000 | 0.31% | Put | |
| 36 | PANAGORA ASSET MANAGEMENT INC | 236,369 | 1,085,000 | 0.31% | ||
| 37 | Numeric Investors LLC | 219,000 | 1,005,000 | 0.28% | ||
| 38 | Nationwide Fund Advisors | 214,919 | 986,000 | 0.28% | ||
| 39 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 194,000 | 890,000 | 0.25% | ||
| 40 | Weiss Multi-Strategy Advisers LLC | 180,000 | 826,000 | 0.23% | ||
| 41 | EVENTIDE ASSET MANAGEMENT, LLC | 177,200 | 813,000 | 0.23% | ||
| 42 | Absolute Return Capital, LLC | 161,669 | 742,000 | 0.21% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,245 | 741,000 | 0.21% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 153,115 | 703,000 | 0.20% | ||
| 45 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 145,922 | 669,000 | 0.19% | ||
| 46 | DEUTSCHE BANK AG\ | 119,226 | 546,000 | 0.15% | ||
| 47 | TEACHERS ADVISORS, LLC | 117,454 | 539,000 | 0.15% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 116,900 | 537,000 | 0.15% | ||
| 49 | ROYAL BANK OF CANADA | 108,621 | 498,000 | 0.14% | ||
| 50 | ProShare Advisors LLC | 105,679 | 485,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
