| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 16,924,013 | 60,757,000 | 19.70% | ||
| 2 | FMR LLC | 16,144,776 | 57,960,000 | 18.80% | ||
| 3 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,373,869 | 22,882,000 | 7.42% | ||
| 4 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 6,122,531 | 21,980,000 | 7.13% | ||
| 5 | STATE STREET CORP | 4,808,134 | 17,258,000 | 5.60% | ||
| 6 | BlackRock Fund Advisors | 3,777,490 | 13,561,000 | 4.40% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 2,739,197 | 9,834,000 | 3.19% | ||
| 8 | VANGUARD GROUP INC | 2,638,545 | 9,472,000 | 3.07% | ||
| 9 | D. E. Shaw & Co., Inc. | 2,239,711 | 8,040,000 | 2.61% | ||
| 10 | ORBIMED ADVISORS LLC | 2,000,000 | 7,180,000 | 2.33% | ||
| 11 | MARSHALL WACE, LLP | 1,915,290 | 6,876,000 | 2.23% | ||
| 12 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,835,900 | 6,591,000 | 2.14% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 1,431,553 | 5,139,000 | 1.67% | ||
| 14 | Artal Group S.A. | 1,200,000 | 4,308,000 | 1.40% | ||
| 15 | Artal Group S.A. | 1,080,000 | 3,877,000 | 1.26% | Call | |
| 16 | NORTHERN TRUST CORP | 928,380 | 3,332,000 | 1.08% | ||
| 17 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 910,000 | 3,267,000 | 1.06% | Call | |
| 18 | Palo Alto Investors LP | 794,500 | 2,852,000 | 0.92% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 756,100 | 2,714,000 | 0.88% | Put | |
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 698,945 | 2,509,000 | 0.81% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 632,500 | 2,271,000 | 0.74% | Call | |
| 22 | JPMORGAN CHASE & CO | 571,242 | 2,051,000 | 0.67% | ||
| 23 | TWO SIGMA INVESTMENTS, LP | 561,250 | 2,015,000 | 0.65% | ||
| 24 | SABBY MANAGEMENT, LLC | 501,745 | 1,801,000 | 0.58% | ||
| 25 | COLUMBUS CIRCLE INVESTORS | 471,720 | 1,693,000 | 0.55% | ||
| 26 | HealthCor Management, L.P. | 450,000 | 1,616,000 | 0.52% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 428,278 | 1,537,000 | 0.50% | ||
| 28 | Bank of New York Mellon Corp | 406,629 | 1,460,000 | 0.47% | ||
| 29 | CREDIT SUISSE AG/ | 305,774 | 1,099,000 | 0.36% | ||
| 30 | SMITH ASSET MANAGEMENT GROUP LP | 304,760 | 1,094,000 | 0.35% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 273,600 | 1,010,000 | 0.33% | ||
| 32 | MORGAN STANLEY | 280,311 | 1,006,000 | 0.33% | ||
| 33 | BlackRock Investment Management, LLC | 263,829 | 947,000 | 0.31% | ||
| 34 | GOLDMAN SACHS GROUP INC | 244,538 | 878,000 | 0.28% | ||
| 35 | AMERICAN INTERNATIONAL GROUP, INC. | 239,215 | 858,782 | 0.28% | ||
| 36 | Connor, Clark & Lunn Investment Management Ltd. | 222,700 | 799,000 | 0.26% | ||
| 37 | Quantitative Systematic Strategies LLC | 220,803 | 792,000 | 0.26% | ||
| 38 | Nationwide Fund Advisors | 211,664 | 760,000 | 0.25% | ||
| 39 | Jefferies Group LLC | 190,000 | 682,000 | 0.22% | Call | |
| 40 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 190,000 | 682,000 | 0.22% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 189,269 | 680,000 | 0.22% | ||
| 42 | Weiss Multi-Strategy Advisers LLC | 180,000 | 646,000 | 0.21% | ||
| 43 | EVENTIDE ASSET MANAGEMENT, LLC | 177,200 | 636,000 | 0.21% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 168,556 | 605,000 | 0.20% | ||
| 45 | ROYAL BANK OF CANADA | 147,547 | 529,000 | 0.17% | ||
| 46 | A.R.T. Advisors, LLC | 146,882 | 527,000 | 0.17% | ||
| 47 | Swiss National Bank | 136,900 | 491,000 | 0.16% | ||
| 48 | PANAGORA ASSET MANAGEMENT INC | 130,424 | 468,000 | 0.15% | ||
| 49 | TEACHERS ADVISORS, LLC | 117,454 | 422,000 | 0.14% | ||
| 50 | Numeric Investors LLC | 111,200 | 399,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
