| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SC XII MANAGEMENT LLC | 7,744,460 | 73,727,000 | 28.42% | ||
| 2 | Capital World Investors | 3,997,803 | 38,059,000 | 14.67% | ||
| 3 | HEALTHCOR PARTNERS MANAGEMENT LP | 1,992,090 | 18,965,000 | 7.31% | ||
| 4 | Murphy Michael R | 1,682,422 | 16,017,000 | 6.17% | ||
| 5 | FRANKLIN RESOURCES INC | 1,615,328 | 15,378,000 | 5.93% | ||
| 6 | VANGUARD GROUP INC | 1,405,063 | 13,377,000 | 5.16% | ||
| 7 | ORBIMED ADVISORS LLC | 1,276,190 | 12,149,000 | 4.68% | ||
| 8 | JENNISON ASSOCIATES LLC | 1,051,463 | 10,010,000 | 3.86% | ||
| 9 | Tekla Capital Management LLC | 882,358 | 8,400,000 | 3.24% | ||
| 10 | Contrarius Investment Management Ltd | 837,477 | 7,973,000 | 3.07% | ||
| 11 | RA CAPITAL MANAGEMENT, L.P. | 783,520 | 7,459,000 | 2.88% | ||
| 12 | Fiera Capital Corp | 741,314 | 7,057,000 | 2.72% | ||
| 13 | BAKER BROS. ADVISORS LP | 450,000 | 4,284,000 | 1.65% | ||
| 14 | HealthCor Management, L.P. | 286,800 | 2,730,000 | 1.05% | ||
| 15 | Portolan Capital Management, LLC | 257,787 | 2,454,000 | 0.95% | ||
| 16 | BlackRock Fund Advisors | 234,515 | 2,233,000 | 0.86% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 182,885 | 1,741,000 | 0.67% | ||
| 18 | WADDELL & REED FINANCIAL INC | 182,166 | 1,734,000 | 0.67% | ||
| 19 | WALL STREET ASSOCIATES | 170,600 | 1,624,000 | 0.63% | ||
| 20 | STATE STREET CORP | 121,834 | 1,160,000 | 0.45% | ||
| 21 | NORTHERN TRUST CORP | 106,397 | 1,013,000 | 0.39% | ||
| 22 | PRINCIPAL FINANCIAL GROUP INC | 102,774 | 979,000 | 0.38% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 88,776 | 845,000 | 0.33% | ||
| 24 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 85,000 | 809,000 | 0.31% | ||
| 25 | GLOBEFLEX CAPITAL L P | 76,091 | 724,000 | 0.28% | ||
| 26 | SABBY MANAGEMENT, LLC | 69,272 | 659,000 | 0.25% | ||
| 27 | MORGAN STANLEY | 63,574 | 605,000 | 0.23% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,600 | 501,000 | 0.19% | Put | |
| 29 | HighTower Advisors, LLC | 49,080 | 467,000 | 0.18% | ||
| 30 | Nationwide Fund Advisors | 48,574 | 462,000 | 0.18% | ||
| 31 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 48,000 | 457,000 | 0.18% | ||
| 32 | Bank of New York Mellon Corp | 43,930 | 418,000 | 0.16% | ||
| 33 | D. E. Shaw & Co., Inc. | 41,302 | 393,000 | 0.15% | ||
| 34 | TFS CAPITAL LLC | 39,170 | 373,000 | 0.14% | ||
| 35 | MARINER INVESTMENT GROUP LLC | 36,600 | 348,000 | 0.13% | ||
| 36 | Diversified Trust Co | 35,283 | 336,000 | 0.13% | ||
| 37 | MILLENNIUM MANAGEMENT LLC | 34,795 | 331,000 | 0.13% | ||
| 38 | BlackRock Investment Management, LLC | 32,795 | 312,000 | 0.12% | ||
| 39 | RTW INVESTMENTS, LP | 31,693 | 302,000 | 0.12% | ||
| 40 | BANK OF MONTREAL /CAN/ | 31,446 | 299,000 | 0.12% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,160 | 259,000 | 0.10% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,343 | 251,000 | 0.10% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,130 | 249,000 | 0.10% | ||
| 44 | SECOR Capital Advisors, LP | 24,729 | 235,000 | 0.09% | ||
| 45 | STRS OHIO | 23,100 | 219,000 | 0.08% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 21,517 | 205,000 | 0.08% | ||
| 47 | GOLDMAN SACHS GROUP INC | 13,271 | 126,000 | 0.05% | ||
| 48 | TEACHERS ADVISORS, LLC | 10,908 | 104,000 | 0.04% | ||
| 49 | ALAMBIC INVESTMENT MANAGEMENT, L.P. | 10,400 | 99,000 | 0.04% | ||
| 50 | TUDOR INVESTMENT CORP ET AL | 10,321 | 98,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
