| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SC XII MANAGEMENT LLC | 7,744,460 | 90,688,000 | 24.50% | ||
| 2 | Capital World Investors | 4,190,609 | 49,072,000 | 13.25% | ||
| 3 | VANGUARD GROUP INC | 1,923,564 | 22,525,000 | 6.08% | ||
| 4 | SOFINNOVA MANAGEMENT VIII, L.L.C. | 1,550,280 | 18,154,000 | 4.90% | ||
| 5 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1,330,587 | 15,581,000 | 4.21% | ||
| 6 | ORBIMED ADVISORS LLC | 1,276,190 | 14,944,000 | 4.04% | ||
| 7 | FRANKLIN RESOURCES INC | 1,044,858 | 12,235,000 | 3.30% | ||
| 8 | EverPoint Asset Management, LLC | 1,017,800 | 11,918,000 | 3.22% | ||
| 9 | JENNISON ASSOCIATES LLC | 999,823 | 11,708,000 | 3.16% | ||
| 10 | Tekla Capital Management LLC | 882,358 | 10,332,000 | 2.79% | ||
| 11 | BlackRock Fund Advisors | 772,422 | 9,045,000 | 2.44% | ||
| 12 | LORD, ABBETT & CO. LLC | 648,010 | 7,588,000 | 2.05% | ||
| 13 | Bank of New York Mellon Corp | 642,768 | 7,527,000 | 2.03% | ||
| 14 | Contrarius Investment Management Ltd | 510,014 | 5,972,000 | 1.61% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 509,485 | 5,966,000 | 1.61% | ||
| 16 | Point72 Asset Management, L.P. | 501,200 | 5,869,000 | 1.59% | ||
| 17 | STATE STREET CORP | 389,498 | 4,561,000 | 1.23% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 320,800 | 3,757,000 | 1.01% | ||
| 19 | Fiera Capital Corp | 306,579 | 3,590,000 | 0.97% | ||
| 20 | HealthCor Management, L.P. | 299,300 | 3,505,000 | 0.95% | ||
| 21 | NORTHERN TRUST CORP | 293,995 | 3,442,000 | 0.93% | ||
| 22 | MORGAN STANLEY | 283,638 | 3,320,000 | 0.90% | ||
| 23 | BAKER BROS. ADVISORS LP | 249,269 | 2,919,000 | 0.79% | ||
| 24 | Polar Asset Management Partners Inc. | 228,060 | 2,671,000 | 0.72% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 224,474 | 2,628,000 | 0.71% | ||
| 26 | PRICE T ROWE ASSOCIATES INC /MD/ | 221,783 | 2,597,000 | 0.70% | ||
| 27 | KORNITZER CAPITAL MANAGEMENT INC /KS | 213,380 | 2,499,000 | 0.68% | ||
| 28 | WADDELL & REED FINANCIAL INC | 206,266 | 2,415,000 | 0.65% | ||
| 29 | D. E. Shaw & Co., Inc. | 203,434 | 2,382,000 | 0.64% | ||
| 30 | CITADEL ADVISORS LLC | 169,861 | 1,988,000 | 0.54% | ||
| 31 | SECOR Capital Advisors, LP | 130,794 | 1,532,000 | 0.41% | ||
| 32 | AlpInvest Partners B.V. | 117,908 | 1,381,000 | 0.37% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 116,125 | 1,360,000 | 0.37% | ||
| 34 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 114,100 | 1,336,000 | 0.36% | ||
| 35 | PRINCIPAL FINANCIAL GROUP INC | 110,590 | 1,295,000 | 0.35% | ||
| 36 | DISCOVERY GROUP I, LLC | 106,372 | 1,246,000 | 0.34% | ||
| 37 | TFS CAPITAL LLC | 100,172 | 1,173,000 | 0.32% | ||
| 38 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 100,000 | 1,171,000 | 0.32% | ||
| 39 | BlackRock Investment Management, LLC | 96,196 | 1,126,000 | 0.30% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 85,494 | 1,002,000 | 0.27% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 82,158 | 962,000 | 0.26% | ||
| 42 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 59,300 | 694,000 | 0.19% | ||
| 43 | Nationwide Fund Advisors | 58,027 | 679,000 | 0.18% | ||
| 44 | STRS OHIO | 57,400 | 672,000 | 0.18% | ||
| 45 | WALL STREET ASSOCIATES | 53,966 | 632,000 | 0.17% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,689 | 629,000 | 0.17% | ||
| 47 | GLOBEFLEX CAPITAL L P | 50,791 | 595,000 | 0.16% | ||
| 48 | HighTower Advisors, LLC | 50,115 | 587,000 | 0.16% | ||
| 49 | WELLS FARGO & COMPANY/MN | 48,122 | 564,000 | 0.15% | ||
| 50 | BLACKROCK ADVISORS LLC | 47,513 | 556,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
