| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SC XII MANAGEMENT LLC | 7,744,460 | 86,041,000 | 23.96% | ||
| 2 | Capital World Investors | 4,099,803 | 45,549,000 | 12.68% | ||
| 3 | HEALTHCOR PARTNERS MANAGEMENT LP | 1,992,090 | 22,132,000 | 6.16% | ||
| 4 | VANGUARD GROUP INC | 1,840,746 | 20,451,000 | 5.69% | ||
| 5 | ORBIMED ADVISORS LLC | 1,276,190 | 14,178,000 | 3.95% | ||
| 6 | FRANKLIN RESOURCES INC | 1,246,858 | 13,853,000 | 3.86% | ||
| 7 | DISCOVERY GROUP I, LLC | 1,224,012 | 13,599,000 | 3.79% | ||
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1,162,645 | 12,917,000 | 3.60% | ||
| 9 | JENNISON ASSOCIATES LLC | 997,691 | 11,084,000 | 3.09% | ||
| 10 | Tekla Capital Management LLC | 882,358 | 9,803,000 | 2.73% | ||
| 11 | EverPoint Asset Management, LLC | 700,000 | 7,777,000 | 2.17% | ||
| 12 | BlackRock Fund Advisors | 664,048 | 7,378,000 | 2.05% | ||
| 13 | Contrarius Investment Management Ltd | 639,961 | 7,110,000 | 1.98% | ||
| 14 | Bank of New York Mellon Corp | 637,082 | 7,078,000 | 1.97% | ||
| 15 | Portolan Capital Management, LLC | 549,570 | 6,106,000 | 1.70% | ||
| 16 | LORD, ABBETT & CO. LLC | 502,293 | 5,580,000 | 1.55% | ||
| 17 | BAKER BROS. ADVISORS LP | 450,000 | 5,000,000 | 1.39% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 416,002 | 4,622,000 | 1.29% | ||
| 19 | STATE STREET CORP | 378,431 | 4,204,000 | 1.17% | ||
| 20 | Fiera Capital Corp | 306,579 | 3,406,000 | 0.95% | ||
| 21 | HealthCor Management, L.P. | 294,800 | 3,275,000 | 0.91% | ||
| 22 | NORTHERN TRUST CORP | 282,291 | 3,137,000 | 0.87% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 252,892 | 2,810,000 | 0.78% | ||
| 24 | PRICE T ROWE ASSOCIATES INC /MD/ | 232,747 | 2,586,000 | 0.72% | ||
| 25 | JPMORGAN CHASE & CO | 228,571 | 2,539,000 | 0.71% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 217,905 | 2,420,000 | 0.67% | ||
| 27 | RENAISSANCE TECHNOLOGIES LLC | 211,900 | 2,354,000 | 0.66% | ||
| 28 | CITADEL ADVISORS LLC | 207,661 | 2,307,000 | 0.64% | ||
| 29 | WADDELL & REED FINANCIAL INC | 206,266 | 2,292,000 | 0.64% | ||
| 30 | SECOR Capital Advisors, LP | 172,075 | 1,912,000 | 0.53% | ||
| 31 | WALL STREET ASSOCIATES | 170,600 | 1,895,000 | 0.53% | ||
| 32 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 134,700 | 1,496,000 | 0.42% | ||
| 33 | AlpInvest Partners B.V. | 117,908 | 1,310,000 | 0.36% | ||
| 34 | TFS CAPITAL LLC | 111,252 | 1,236,000 | 0.34% | ||
| 35 | PRINCIPAL FINANCIAL GROUP INC | 109,225 | 1,214,000 | 0.34% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 103,299 | 1,148,000 | 0.32% | ||
| 37 | BlackRock Investment Management, LLC | 95,297 | 1,059,000 | 0.29% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 80,083 | 890,000 | 0.25% | ||
| 39 | HAMILTON LANE ADVISORS LLC | 74,372 | 826,000 | 0.23% | ||
| 40 | Point72 Asset Management, L.P. | 73,900 | 821,000 | 0.23% | ||
| 41 | Nationwide Fund Advisors | 57,267 | 636,000 | 0.18% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,089 | 612,000 | 0.17% | ||
| 43 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 55,000 | 611,000 | 0.17% | ||
| 44 | MORGAN STANLEY | 54,025 | 600,000 | 0.17% | ||
| 45 | PANAGORA ASSET MANAGEMENT INC | 52,973 | 589,000 | 0.16% | ||
| 46 | STRS OHIO | 51,304 | 569,000 | 0.16% | ||
| 47 | GLOBEFLEX CAPITAL L P | 50,791 | 564,000 | 0.16% | ||
| 48 | HighTower Advisors, LLC | 50,115 | 556,000 | 0.15% | ||
| 49 | BLACKROCK ADVISORS LLC | 47,781 | 531,000 | 0.15% | ||
| 50 | D. E. Shaw & Co., Inc. | 47,183 | 524,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
