| 1 |
SC XII MANAGEMENT LLC |
7,744,460 |
83,640,000 |
31.81% |
|
|
| 2 |
Capital World Investors |
2,833,445 |
30,601,000 |
11.64% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
2,040,328 |
22,035,000 |
8.38% |
|
|
| 4 |
HEALTHCOR PARTNERS MANAGEMENT LP |
1,992,090 |
21,515,000 |
8.18% |
|
|
| 5 |
ORBIMED ADVISORS LLC |
1,276,190 |
13,783,000 |
5.24% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
1,100,862 |
11,889,000 |
4.52% |
|
|
| 7 |
GOLDMAN SACHS GROUP INC |
921,269 |
9,950,000 |
3.78% |
|
|
| 8 |
Tekla Capital Management LLC |
882,358 |
9,529,000 |
3.62% |
|
|
| 9 |
Contrarius Investment Management Ltd |
807,814 |
8,724,000 |
3.32% |
|
|
| 10 |
RA CAPITAL MANAGEMENT, L.P. |
783,520 |
8,462,000 |
3.22% |
|
|
| 11 |
VANGUARD GROUP INC |
745,612 |
8,053,000 |
3.06% |
|
|
| 12 |
MILLENNIUM MANAGEMENT LLC |
617,312 |
6,667,000 |
2.54% |
|
|
| 13 |
HealthCor Management, L.P. |
275,000 |
2,970,000 |
1.13% |
|
|
| 14 |
BAKER BROS. ADVISORS LP |
250,000 |
2,700,000 |
1.03% |
|
|
| 15 |
BlackRock Fund Advisors |
246,566 |
2,663,000 |
1.01% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
185,708 |
2,006,000 |
0.76% |
|
|
| 17 |
WADDELL & REED FINANCIAL INC |
182,166 |
1,968,000 |
0.75% |
|
|
| 18 |
WALL STREET ASSOCIATES |
170,600 |
1,842,000 |
0.70% |
|
|
| 19 |
STATE STREET CORP |
110,756 |
1,196,000 |
0.45% |
|
|
| 20 |
NORTHERN TRUST CORP |
105,999 |
1,145,000 |
0.44% |
|
|
| 21 |
PRINCIPAL FINANCIAL GROUP INC |
103,541 |
1,118,000 |
0.43% |
|
|
| 22 |
CITADEL ADVISORS LLC |
87,357 |
943,000 |
0.36% |
|
|
| 23 |
SABBY MANAGEMENT, LLC |
86,623 |
936,000 |
0.36% |
|
|
| 24 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
80,000 |
864,000 |
0.33% |
|
|
| 25 |
GEODE CAPITAL MANAGEMENT, LLC |
70,287 |
759,000 |
0.29% |
|
|
| 26 |
COLUMBUS CIRCLE INVESTORS |
67,481 |
729,000 |
0.28% |
|
|
| 27 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
54,900 |
593,000 |
0.23% |
Put |
|
| 28 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
48,000 |
518,000 |
0.20% |
|
|
| 29 |
MORGAN STANLEY |
44,386 |
479,000 |
0.18% |
|
|
| 30 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
36,756 |
397,000 |
0.15% |
|
|
| 31 |
GILDER GAGNON HOWE & CO LLC |
32,191 |
348,000 |
0.13% |
|
|
| 32 |
BlackRock Investment Management, LLC |
32,025 |
346,000 |
0.13% |
|
|
| 33 |
RTW INVESTMENTS, LP |
31,693 |
342,000 |
0.13% |
|
|
| 34 |
MARINER INVESTMENT GROUP LLC |
31,300 |
338,000 |
0.13% |
|
|
| 35 |
Bank of New York Mellon Corp |
29,363 |
317,000 |
0.12% |
|
|
| 36 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
27,466 |
297,000 |
0.11% |
|
|
| 37 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
25,620 |
277,000 |
0.11% |
|
|
| 38 |
STRS OHIO |
23,100 |
249,000 |
0.09% |
|
|
| 39 |
ACADIAN ASSET MANAGEMENT LLC |
19,723 |
213,000 |
0.08% |
|
|
| 40 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
18,529 |
200,000 |
0.08% |
|
|
| 41 |
BANK OF MONTREAL /CAN/ |
18,483 |
200,000 |
0.08% |
|
|
| 42 |
GLG LLC |
18,023 |
195,000 |
0.07% |
|
|
| 43 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13,100 |
141,000 |
0.05% |
Call |
|
| 44 |
WELLS FARGO & COMPANY/MN |
11,161 |
121,000 |
0.05% |
|
|
| 45 |
TEACHERS ADVISORS, LLC |
10,908 |
118,000 |
0.04% |
|
|
| 46 |
FORMULA GROWTH LTD |
10,000 |
108,000 |
0.04% |
|
|
| 47 |
GLOBEFLEX CAPITAL L P |
8,800 |
95,000 |
0.04% |
|
|
| 48 |
NEW YORK STATE COMMON RETIREMENT FUND |
7,900 |
85,000 |
0.03% |
|
|
| 49 |
Nationwide Fund Advisors |
5,792 |
63,000 |
0.02% |
|
|
| 50 |
BLACKROCK ADVISORS LLC |
3,688 |
40,000 |
0.02% |
|
|
