| 1 |
SC XII MANAGEMENT LLC |
7,744,460 |
84,027,000 |
36.12% |
|
|
| 2 |
Capital World Investors |
1,795,567 |
18,972,000 |
8.16% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
1,612,170 |
17,492,000 |
7.52% |
|
|
| 4 |
GOLDMAN SACHS GROUP INC |
1,507,541 |
16,357,000 |
7.03% |
|
|
| 5 |
ORBIMED ADVISORS LLC |
1,276,190 |
13,847,000 |
5.95% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
1,143,532 |
12,301,000 |
5.29% |
|
|
| 7 |
Tekla Capital Management LLC |
814,300 |
8,835,000 |
3.80% |
|
|
| 8 |
RA CAPITAL MANAGEMENT, L.P. |
783,521 |
8,501,000 |
3.65% |
|
|
| 9 |
VANGUARD GROUP INC |
535,149 |
5,807,000 |
2.50% |
|
|
| 10 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
456,657 |
4,955,000 |
2.13% |
|
|
| 11 |
Contrarius Investment Management Ltd |
394,956 |
4,285,000 |
1.84% |
|
|
| 12 |
MARSICO CAPITAL MANAGEMENT LLC |
297,554 |
3,228,000 |
1.39% |
|
|
| 13 |
HealthCor Management, L.P. |
255,000 |
2,767,000 |
1.19% |
|
|
| 14 |
BAKER BROS. ADVISORS LP |
250,000 |
2,713,000 |
1.17% |
|
|
| 15 |
BlackRock Fund Advisors |
238,668 |
2,590,000 |
1.11% |
|
|
| 16 |
AMERIPRISE FINANCIAL INC |
231,618 |
2,513,000 |
1.08% |
|
|
| 17 |
WALL STREET ASSOCIATES |
170,600 |
1,851,000 |
0.80% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
158,761 |
1,723,000 |
0.74% |
|
|
| 19 |
LAZARD ASSET MANAGEMENT LLC |
150,925 |
1,637,000 |
0.70% |
|
|
| 20 |
GLG LLC |
147,383 |
1,599,000 |
0.69% |
|
|
| 21 |
WADDELL & REED FINANCIAL INC |
142,700 |
1,548,000 |
0.67% |
|
|
| 22 |
JPMORGAN CHASE & CO |
104,300 |
1,132,000 |
0.49% |
|
|
| 23 |
GILDER GAGNON HOWE & CO LLC |
95,789 |
1,039,000 |
0.45% |
|
|
| 24 |
STATE STREET CORP |
90,388 |
980,000 |
0.42% |
|
|
| 25 |
SABBY MANAGEMENT, LLC |
86,523 |
939,000 |
0.40% |
|
|
| 26 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
80,000 |
868,000 |
0.37% |
|
|
| 27 |
Alyeska Investment Group, L.P. |
75,000 |
814,000 |
0.35% |
|
|
| 28 |
BlackRock Group LTD |
73,292 |
795,000 |
0.34% |
|
|
| 29 |
MAZAMA CAPITAL MANAGEMENT INC |
65,972 |
716,000 |
0.31% |
|
|
| 30 |
PDT Partners, LLC |
62,458 |
678,000 |
0.29% |
|
|
| 31 |
CITADEL ADVISORS LLC |
62,065 |
673,000 |
0.29% |
|
|
| 32 |
EMERALD MUTUAL FUND ADVISERS TRUST |
60,000 |
651,000 |
0.28% |
|
|
| 33 |
GEODE CAPITAL MANAGEMENT, LLC |
51,778 |
561,000 |
0.24% |
|
|
| 34 |
PRINCIPAL FINANCIAL GROUP INC |
50,175 |
545,000 |
0.23% |
|
|
| 35 |
MORGAN STANLEY |
42,984 |
467,000 |
0.20% |
|
|
| 36 |
FRED ALGER MANAGEMENT, LLC |
37,800 |
410,000 |
0.18% |
|
|
| 37 |
RTW INVESTMENTS, LP |
31,693 |
344,000 |
0.15% |
|
|
| 38 |
BlackRock Investment Management, LLC |
31,206 |
339,000 |
0.15% |
|
|
| 39 |
Dynamic Technology Lab Private Ltd |
28,543 |
310,000 |
0.13% |
|
|
| 40 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
27,466 |
298,000 |
0.13% |
|
|
| 41 |
MILLENNIUM MANAGEMENT LLC |
25,936 |
281,000 |
0.12% |
|
|
| 42 |
NORTHERN TRUST CORP |
25,646 |
279,000 |
0.12% |
|
|
| 43 |
Bank of New York Mellon Corp |
24,461 |
265,000 |
0.11% |
|
|
| 44 |
NORGES BANK |
24,100 |
261,000 |
0.11% |
|
|
| 45 |
CREDIT SUISSE AG/ |
20,315 |
220,000 |
0.09% |
|
|
| 46 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
18,200 |
197,000 |
0.08% |
|
|
| 47 |
G2 Investment Partners Management LLC |
15,000 |
163,000 |
0.07% |
|
|
| 48 |
WELLS FARGO & COMPANY/MN |
12,831 |
139,000 |
0.06% |
|
|
| 49 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
11,970 |
130,000 |
0.06% |
|
|
| 50 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
11,700 |
127,000 |
0.05% |
Call |
|
