| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SC XII MANAGEMENT LLC | 7,744,460 | 93,437,000 | 23.69% | ||
| 2 | Capital World Investors | 3,997,803 | 48,233,000 | 12.23% | ||
| 3 | HEALTHCOR PARTNERS MANAGEMENT LP | 1,992,090 | 24,025,000 | 6.09% | ||
| 4 | Murphy Michael R | 1,729,013 | 20,861,000 | 5.29% | ||
| 5 | VANGUARD GROUP INC | 1,636,821 | 19,748,000 | 5.01% | ||
| 6 | ORBIMED ADVISORS LLC | 1,276,190 | 15,397,000 | 3.90% | ||
| 7 | FRANKLIN RESOURCES INC | 1,246,858 | 15,043,000 | 3.81% | ||
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1,068,397 | 12,890,000 | 3.27% | ||
| 9 | JENNISON ASSOCIATES LLC | 1,050,731 | 12,677,000 | 3.21% | ||
| 10 | Tekla Capital Management LLC | 882,358 | 10,646,000 | 2.70% | ||
| 11 | EverPoint Asset Management, LLC | 800,000 | 9,652,000 | 2.45% | ||
| 12 | RA CAPITAL MANAGEMENT, L.P. | 783,520 | 9,453,000 | 2.40% | ||
| 13 | Contrarius Investment Management Ltd | 724,750 | 8,744,000 | 2.22% | ||
| 14 | BlackRock Fund Advisors | 618,272 | 7,459,000 | 1.89% | ||
| 15 | LORD, ABBETT & CO. LLC | 520,216 | 6,277,000 | 1.59% | ||
| 16 | Portolan Capital Management, LLC | 520,037 | 6,274,000 | 1.59% | ||
| 17 | Bank of New York Mellon Corp | 480,900 | 5,802,000 | 1.47% | ||
| 18 | BAKER BROS. ADVISORS LP | 450,000 | 5,429,000 | 1.38% | ||
| 19 | STATE STREET CORP | 362,889 | 4,377,000 | 1.11% | ||
| 20 | PRICE T ROWE ASSOCIATES INC /MD/ | 361,223 | 4,358,000 | 1.10% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 356,717 | 4,304,000 | 1.09% | ||
| 22 | Fiera Capital Corp | 306,579 | 3,699,000 | 0.94% | ||
| 23 | HealthCor Management, L.P. | 290,600 | 3,506,000 | 0.89% | ||
| 24 | JPMORGAN CHASE & CO | 276,030 | 3,330,000 | 0.84% | ||
| 25 | NORTHERN TRUST CORP | 266,247 | 3,212,000 | 0.81% | ||
| 26 | WADDELL & REED FINANCIAL INC | 188,166 | 2,271,000 | 0.58% | ||
| 27 | WALL STREET ASSOCIATES | 170,600 | 2,058,000 | 0.52% | ||
| 28 | AlpInvest Partners B.V. | 159,813 | 1,928,000 | 0.49% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 119,756 | 1,444,000 | 0.37% | ||
| 30 | Spark Investment Management LLC | 112,000 | 1,351,000 | 0.34% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 108,913 | 1,314,000 | 0.33% | ||
| 32 | PRINCIPAL FINANCIAL GROUP INC | 100,986 | 1,219,000 | 0.31% | ||
| 33 | HAMILTON LANE ADVISORS LLC | 87,607 | 1,208,000 | 0.31% | ||
| 34 | BlackRock Investment Management, LLC | 95,541 | 1,153,000 | 0.29% | ||
| 35 | HARBOURVEST PARTNERS LLC | 87,418 | 1,054,000 | 0.27% | ||
| 36 | RENAISSANCE TECHNOLOGIES LLC | 85,800 | 1,035,000 | 0.26% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 85,463 | 1,031,000 | 0.26% | ||
| 38 | Point72 Asset Management, L.P. | 79,200 | 956,000 | 0.24% | ||
| 39 | SECOR Capital Advisors, LP | 73,399 | 886,000 | 0.22% | ||
| 40 | Informed Momentum Co LLC | 62,378 | 753,000 | 0.19% | ||
| 41 | MORGAN STANLEY | 60,091 | 726,000 | 0.18% | ||
| 42 | Nationwide Fund Advisors | 58,822 | 710,000 | 0.18% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,689 | 660,000 | 0.17% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 53,850 | 650,000 | 0.16% | ||
| 45 | OXFORD ASSET MANAGEMENT LLP | 52,880 | 638,000 | 0.16% | ||
| 46 | GLOBEFLEX CAPITAL L P | 50,791 | 613,000 | 0.16% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,300 | 607,000 | 0.15% | Put | |
| 48 | HighTower Advisors, LLC | 50,200 | 605,000 | 0.15% | ||
| 49 | MARINER INVESTMENT GROUP LLC | 49,800 | 601,000 | 0.15% | ||
| 50 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 48,000 | 579,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
