| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,306,862 | 54,894,000 | 22.22% | ||
| 2 | Bain Capital Public Equity Management, LLC | 1,934,961 | 32,120,000 | 13.00% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,169,042 | 19,406,000 | 7.85% | ||
| 4 | VHCP MANAGEMENT II, LLC | 1,030,954 | 15,874,000 | 6.42% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 972,933 | 15,587,000 | 6.31% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 779,213 | 12,934,000 | 5.23% | ||
| 7 | RS INVESTMENT MANAGEMENT CO LLC | 746,592 | 12,393,000 | 5.02% | ||
| 8 | JPMORGAN CHASE & CO | 358,752 | 5,955,000 | 2.41% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 350,700 | 5,822,000 | 2.36% | ||
| 10 | Weiss Multi-Strategy Advisers LLC | 336,474 | 5,585,000 | 2.26% | ||
| 11 | JENNISON ASSOCIATES LLC | 338,078 | 5,558,000 | 2.25% | ||
| 12 | QVT Financial LP | 351,525 | 5,185,000 | 2.10% | ||
| 13 | Invesco Ltd. | 300,200 | 4,983,000 | 2.02% | ||
| 14 | Visium Asset Management, LP | 253,923 | 4,215,000 | 1.71% | ||
| 15 | JANUS HENDERSON INVESTORS US LLC | 222,210 | 3,689,000 | 1.49% | ||
| 16 | RTW INVESTMENTS, LP | 217,210 | 3,606,000 | 1.46% | ||
| 17 | VANGUARD GROUP INC | 203,322 | 3,375,000 | 1.37% | ||
| 18 | BlackRock Fund Advisors | 195,121 | 3,239,000 | 1.31% | ||
| 19 | FEDERATED HERMES, INC. | 175,000 | 2,905,000 | 1.18% | ||
| 20 | Artal Group S.A. | 160,000 | 2,656,000 | 1.07% | ||
| 21 | Cormorant Asset Management, LP | 156,741 | 2,602,000 | 1.05% | ||
| 22 | Foresite Capital Management II, LLC | 156,741 | 2,602,000 | 1.05% | ||
| 23 | PFM Health Sciences, LP | 119,092 | 1,977,000 | 0.80% | ||
| 24 | SABBY MANAGEMENT, LLC | 116,860 | 1,940,000 | 0.79% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 108,954 | 1,809,000 | 0.73% | ||
| 26 | FORESITE CAPITAL MANAGEMENT III, LLC | 100,000 | 1,660,000 | 0.67% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 77,075 | 1,279,000 | 0.52% | ||
| 28 | NORTHERN TRUST CORP | 68,530 | 1,138,000 | 0.46% | ||
| 29 | FRANKLIN RESOURCES INC | 63,400 | 1,052,000 | 0.43% | ||
| 30 | Ghost Tree Capital, LLC | 60,000 | 996,000 | 0.40% | ||
| 31 | STATE STREET CORP | 57,525 | 954,000 | 0.39% | ||
| 32 | VHCP Management, LLC | 52,500 | 872,000 | 0.35% | ||
| 33 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 50,000 | 830,000 | 0.34% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 48,887 | 811,000 | 0.33% | ||
| 35 | GRATICULE ASIA MACRO ADVISORS LLC | 39,800 | 662,000 | 0.27% | ||
| 36 | PICTET ASSET MANAGEMENT LTD | 35,700 | 593,000 | 0.24% | ||
| 37 | BlackRock Institutional Trust Company, N.A. | 30,861 | 512,000 | 0.21% | ||
| 38 | D. E. Shaw & Co., Inc. | 29,907 | 496,000 | 0.20% | ||
| 39 | DEUTSCHE BANK AG\ | 29,600 | 490,000 | 0.20% | ||
| 40 | BlackRock Investment Management, LLC | 25,317 | 420,000 | 0.17% | ||
| 41 | Spark Investment Management LLC | 22,900 | 380,000 | 0.15% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,627 | 376,000 | 0.15% | ||
| 43 | NORGES BANK | 20,000 | 332,000 | 0.13% | ||
| 44 | BlackRock Group LTD | 19,194 | 319,000 | 0.13% | ||
| 45 | Bank of New York Mellon Corp | 18,275 | 303,000 | 0.12% | ||
| 46 | MORGAN STANLEY | 17,186 | 286,000 | 0.12% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 15,184 | 252,000 | 0.10% | ||
| 48 | OXFORD ASSET MANAGEMENT LLP | 14,642 | 243,000 | 0.10% | ||
| 49 | GILDER GAGNON HOWE & CO LLC | 14,466 | 240,000 | 0.10% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,450 | 223,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
