| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,077,061 | 33,232,000 | 18.51% | ||
| 2 | Bain Capital Public Equity Management, LLC | 1,928,767 | 20,831,000 | 11.60% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,169,042 | 12,626,000 | 7.03% | ||
| 4 | VHCP MANAGEMENT II, LLC | 1,030,954 | 11,134,000 | 6.20% | ||
| 5 | VIVO CAPITAL, LLC | 990,449 | 10,697,000 | 5.96% | ||
| 6 | RS INVESTMENT MANAGEMENT CO LLC | 978,403 | 10,567,000 | 5.88% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 976,933 | 10,551,000 | 5.88% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 825,396 | 8,914,000 | 4.96% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 680,241 | 7,347,000 | 4.09% | ||
| 10 | QVT Financial LP | 424,368 | 4,527,000 | 2.52% | ||
| 11 | Weiss Multi-Strategy Advisers LLC | 345,000 | 3,726,000 | 2.08% | ||
| 12 | JPMORGAN CHASE & CO | 331,340 | 3,579,000 | 1.99% | ||
| 13 | SABBY MANAGEMENT, LLC | 300,329 | 3,244,000 | 1.81% | ||
| 14 | Invesco Ltd. | 300,200 | 3,242,000 | 1.81% | ||
| 15 | JENNISON ASSOCIATES LLC | 292,388 | 3,158,000 | 1.76% | ||
| 16 | VANGUARD GROUP INC | 263,339 | 2,844,000 | 1.58% | ||
| 17 | FIL Ltd | 250,148 | 2,702,000 | 1.50% | ||
| 18 | RTW INVESTMENTS, LP | 241,323 | 2,606,000 | 1.45% | ||
| 19 | JANUS HENDERSON INVESTORS US LLC | 218,863 | 2,364,000 | 1.32% | ||
| 20 | Visium Asset Management, LP | 204,342 | 2,207,000 | 1.23% | ||
| 21 | BlackRock Fund Advisors | 185,317 | 2,001,000 | 1.11% | ||
| 22 | Artal Group S.A. | 160,000 | 1,728,000 | 0.96% | ||
| 23 | Cormorant Asset Management, LP | 156,741 | 1,693,000 | 0.94% | ||
| 24 | Foresite Capital Management II, LLC | 156,741 | 1,693,000 | 0.94% | ||
| 25 | PNC FINANCIAL SERVICES GROUP, INC. | 123,318 | 1,332,000 | 0.74% | ||
| 26 | FEDERATED HERMES, INC. | 115,567 | 1,248,000 | 0.70% | ||
| 27 | FORESITE CAPITAL MANAGEMENT III, LLC | 100,000 | 1,080,000 | 0.60% | ||
| 28 | STATE STREET CORP | 88,025 | 950,000 | 0.53% | ||
| 29 | NORTHERN TRUST CORP | 69,026 | 745,000 | 0.41% | ||
| 30 | FRANKLIN RESOURCES INC | 63,400 | 685,000 | 0.38% | ||
| 31 | BlackRock Institutional Trust Company, N.A. | 58,821 | 635,000 | 0.35% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 57,142 | 617,000 | 0.34% | ||
| 33 | VHCP Management, LLC | 52,500 | 567,000 | 0.32% | ||
| 34 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 50,000 | 540,000 | 0.30% | ||
| 35 | PICTET ASSET MANAGEMENT LTD | 35,700 | 433,000 | 0.24% | ||
| 36 | DEUTSCHE BANK AG\ | 28,880 | 311,000 | 0.17% | ||
| 37 | BlackRock Investment Management, LLC | 25,601 | 276,000 | 0.15% | ||
| 38 | STRS OHIO | 24,741 | 267,000 | 0.15% | ||
| 39 | TD ASSET MANAGEMENT INC | 23,165 | 250,000 | 0.14% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,984 | 249,000 | 0.14% | ||
| 41 | Bank of New York Mellon Corp | 19,352 | 208,000 | 0.12% | ||
| 42 | BlackRock Group LTD | 19,194 | 207,000 | 0.12% | ||
| 43 | NORGES BANK | 18,200 | 197,000 | 0.11% | ||
| 44 | FRED ALGER MANAGEMENT, LLC | 18,000 | 194,000 | 0.11% | ||
| 45 | MILLENNIUM MANAGEMENT LLC | 15,832 | 171,000 | 0.10% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,540 | 168,000 | 0.09% | ||
| 47 | People's United Financial, Inc. | 15,440 | 167,000 | 0.09% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 15,184 | 164,000 | 0.09% | ||
| 49 | GSA CAPITAL PARTNERS LLP | 15,100 | 163,000 | 0.09% | ||
| 50 | MORGAN STANLEY | 8,258 | 89,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
