| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Bain Capital Public Equity Management, LLC | 2,472,087 | 34,634,000 | 14.61% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 1,282,286 | 17,964,000 | 7.58% | ||
| 3 | JPMORGAN CHASE & CO | 1,012,666 | 14,188,000 | 5.98% | ||
| 4 | FRANKLIN RESOURCES INC | 990,800 | 13,881,000 | 5.85% | ||
| 5 | VIVO CAPITAL, LLC | 990,449 | 13,876,000 | 5.85% | ||
| 6 | FMR LLC | 860,130 | 12,050,000 | 5.08% | ||
| 7 | VANGUARD GROUP INC | 766,315 | 10,736,000 | 4.53% | ||
| 8 | BLACKROCK ADVISORS LLC | 693,908 | 9,722,000 | 4.10% | ||
| 9 | BlackRock Fund Advisors | 569,726 | 7,982,000 | 3.37% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 526,527 | 7,377,000 | 3.11% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 473,852 | 6,639,000 | 2.80% | ||
| 12 | AXA S.A. | 444,342 | 6,225,000 | 2.63% | ||
| 13 | FIL Ltd | 377,198 | 5,285,000 | 2.23% | ||
| 14 | QVT Financial LP | 370,943 | 5,197,000 | 2.19% | ||
| 15 | VHCP MANAGEMENT II, LLC | 332,494 | 4,658,000 | 1.96% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 308,405 | 4,321,000 | 1.82% | ||
| 17 | Weiss Multi-Strategy Advisers LLC | 305,000 | 4,273,000 | 1.80% | ||
| 18 | Invesco Ltd. | 300,395 | 4,209,000 | 1.78% | ||
| 19 | Artal Group S.A. | 300,000 | 4,203,000 | 1.77% | ||
| 20 | JENNISON ASSOCIATES LLC | 292,022 | 4,091,000 | 1.73% | ||
| 21 | PFM Health Sciences, LP | 287,239 | 4,024,000 | 1.70% | ||
| 22 | STATE STREET CORP | 271,484 | 3,804,000 | 1.60% | ||
| 23 | SABBY MANAGEMENT, LLC | 263,177 | 3,687,000 | 1.55% | ||
| 24 | RTW INVESTMENTS, LP | 238,740 | 3,345,000 | 1.41% | ||
| 25 | SECTORAL ASSET MANAGEMENT INC | 243,613 | 3,221,000 | 1.36% | ||
| 26 | JANUS HENDERSON INVESTORS US LLC | 213,005 | 2,984,000 | 1.26% | ||
| 27 | NORTHERN TRUST CORP | 199,270 | 2,791,000 | 1.18% | ||
| 28 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 175,000 | 2,452,000 | 1.03% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 160,729 | 2,251,000 | 0.95% | ||
| 30 | Cormorant Asset Management, LP | 156,741 | 2,196,000 | 0.93% | ||
| 31 | BlackRock Investment Management, LLC | 83,643 | 1,172,000 | 0.49% | ||
| 32 | Mirae Asset Global Investments Co., Ltd. | 83,400 | 1,168,000 | 0.49% | ||
| 33 | GRATICULE ASIA MACRO ADVISORS LLC | 67,500 | 946,000 | 0.40% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 65,599 | 920,000 | 0.39% | ||
| 35 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 64,852 | 909,000 | 0.38% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 60,056 | 841,000 | 0.35% | ||
| 37 | Bank of New York Mellon Corp | 56,091 | 786,000 | 0.33% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 54,738 | 767,000 | 0.32% | ||
| 39 | VICTORY CAPITAL MANAGEMENT INC | 48,850 | 684,000 | 0.29% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,775 | 599,000 | 0.25% | ||
| 41 | DEUTSCHE BANK AG\ | 38,967 | 544,000 | 0.23% | ||
| 42 | Fernwood Investment Management, LLC | 38,600 | 541,000 | 0.23% | ||
| 43 | TEACHERS ADVISORS, LLC | 32,782 | 459,000 | 0.19% | ||
| 44 | MORGAN STANLEY | 24,106 | 339,000 | 0.14% | ||
| 45 | VHCP Management, LLC | 24,089 | 337,000 | 0.14% | ||
| 46 | TD ASSET MANAGEMENT INC | 22,765 | 319,000 | 0.13% | ||
| 47 | NEW YORK STATE COMMON RETIREMENT FUND | 20,900 | 293,000 | 0.12% | ||
| 48 | RHUMBLINE ADVISERS | 19,858 | 278,000 | 0.12% | ||
| 49 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 18,359 | 258,000 | 0.11% | ||
| 50 | STRS OHIO | 17,000 | 238,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
