| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,074,566 | 67,733,000 | 21.83% | ||
| 2 | Bain Capital Public Equity Management, LLC | 1,934,961 | 42,627,000 | 13.74% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,336,542 | 29,444,000 | 9.49% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 982,613 | 20,899,000 | 6.74% | ||
| 5 | VHCP Management, LLC | 1,083,454 | 20,178,000 | 6.50% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 779,213 | 17,166,000 | 5.53% | ||
| 7 | RS INVESTMENT MANAGEMENT CO LLC | 670,782 | 14,777,000 | 4.76% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 507,441 | 10,834,000 | 3.49% | ||
| 9 | JENNISON ASSOCIATES LLC | 355,344 | 7,668,000 | 2.47% | ||
| 10 | Invesco Ltd. | 300,000 | 6,609,000 | 2.13% | ||
| 11 | JANUS HENDERSON INVESTORS US LLC | 285,892 | 6,298,000 | 2.03% | ||
| 12 | Redmile Group, LLC | 277,000 | 6,102,000 | 1.97% | ||
| 13 | Weiss Multi-Strategy Advisers LLC | 273,974 | 6,036,000 | 1.95% | ||
| 14 | GRATICULE ASIA MACRO ADVISORS LLC | 268,000 | 5,905,000 | 1.90% | ||
| 15 | Visium Asset Management, LP | 253,923 | 5,594,000 | 1.80% | ||
| 16 | JPMORGAN CHASE & CO | 218,474 | 4,813,000 | 1.55% | ||
| 17 | RTW INVESTMENTS, LP | 204,494 | 4,505,000 | 1.45% | ||
| 18 | FEDERATED HERMES, INC. | 175,000 | 3,855,000 | 1.24% | ||
| 19 | Cormorant Asset Management, LP | 156,741 | 3,453,000 | 1.11% | ||
| 20 | Foresite Capital Management II, LLC | 156,741 | 3,453,000 | 1.11% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 118,863 | 2,619,000 | 0.84% | ||
| 22 | Artal Group S.A. | 117,400 | 2,586,000 | 0.83% | ||
| 23 | PFM Health Sciences, LP | 107,305 | 2,364,000 | 0.76% | ||
| 24 | FRANKLIN RESOURCES INC | 100,000 | 2,203,000 | 0.71% | ||
| 25 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 75,000 | 1,652,000 | 0.53% | ||
| 26 | Ghost Tree Capital, LLC | 60,000 | 1,322,000 | 0.43% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 56,303 | 1,240,000 | 0.40% | ||
| 28 | Alyeska Investment Group, L.P. | 51,736 | 1,140,000 | 0.37% | ||
| 29 | CITADEL ADVISORS LLC | 51,686 | 1,139,000 | 0.37% | ||
| 30 | AMERIPRISE FINANCIAL INC | 37,701 | 832,000 | 0.27% | ||
| 31 | PICTET ASSET MANAGEMENT LTD | 35,700 | 787,000 | 0.25% | ||
| 32 | TUDOR INVESTMENT CORP ET AL | 31,150 | 686,000 | 0.22% | ||
| 33 | VANGUARD GROUP INC | 29,966 | 660,000 | 0.21% | ||
| 34 | DEUTSCHE BANK AG\ | 27,778 | 611,000 | 0.20% | ||
| 35 | Laurion Capital Management LP | 27,000 | 595,000 | 0.19% | ||
| 36 | NORGES BANK | 20,000 | 441,000 | 0.14% | ||
| 37 | GILDER GAGNON HOWE & CO LLC | 19,995 | 440,000 | 0.14% | ||
| 38 | BlackRock Group LTD | 19,194 | 423,000 | 0.14% | ||
| 39 | Fortress Investment Group LLC | 11,466 | 253,000 | 0.08% | ||
| 40 | MORGAN STANLEY | 4,097 | 90,000 | 0.03% | ||
| 41 | Partner Investment Management, L.P. | 2,466 | 54,000 | 0.02% | ||
| 42 | CREDIT AGRICOLE S A | 2,000 | 44,000 | 0.01% | ||
| 43 | UBS Group AG | 1,094 | 24,000 | 0.01% | ||
| 44 | Tower Research Capital LLC (TRC) | 940 | 21,000 | 0.01% | ||
| 45 | BlackRock Institutional Trust Company, N.A. | 806 | 18,000 | 0.01% | ||
| 46 | ROYAL BANK OF CANADA | 800 | 18,000 | 0.01% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 185 | 4,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
