| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Bain Capital Public Equity Management, LLC | 1,928,767 | 15,430,000 | 10.48% | ||
| 2 | FMR LLC | 1,922,582 | 15,381,000 | 10.44% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,169,042 | 9,352,000 | 6.35% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 1,099,213 | 8,793,000 | 5.97% | ||
| 5 | VHCP MANAGEMENT II, LLC | 999,633 | 7,997,000 | 5.43% | ||
| 6 | VIVO CAPITAL, LLC | 990,449 | 7,924,000 | 5.38% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 969,233 | 7,754,000 | 5.27% | ||
| 8 | FRANKLIN RESOURCES INC | 700,500 | 5,604,000 | 3.81% | ||
| 9 | BLACKROCK ADVISORS LLC | 687,657 | 5,501,000 | 3.74% | ||
| 10 | VANGUARD GROUP INC | 569,935 | 4,559,000 | 3.10% | ||
| 11 | RS INVESTMENT MANAGEMENT CO LLC | 566,869 | 4,535,000 | 3.08% | ||
| 12 | JANUS HENDERSON INVESTORS US LLC | 527,819 | 4,223,000 | 2.87% | ||
| 13 | BlackRock Fund Advisors | 516,179 | 4,129,000 | 2.80% | ||
| 14 | PICTET ASSET MANAGEMENT LTD | 285,420 | 3,528,000 | 2.40% | ||
| 15 | QVT Financial LP | 424,368 | 3,395,000 | 2.31% | ||
| 16 | SECTORAL ASSET MANAGEMENT INC | 367,541 | 3,379,000 | 2.29% | ||
| 17 | SABBY MANAGEMENT, LLC | 411,926 | 3,295,000 | 2.24% | ||
| 18 | FIL Ltd | 377,198 | 3,018,000 | 2.05% | ||
| 19 | Weiss Multi-Strategy Advisers LLC | 327,559 | 2,620,000 | 1.78% | ||
| 20 | JPMORGAN CHASE & CO | 322,582 | 2,580,000 | 1.75% | ||
| 21 | Invesco Ltd. | 300,452 | 2,404,000 | 1.63% | ||
| 22 | JENNISON ASSOCIATES LLC | 292,402 | 2,339,000 | 1.59% | ||
| 23 | RTW INVESTMENTS, LP | 242,784 | 1,942,000 | 1.32% | ||
| 24 | STATE STREET CORP | 238,396 | 1,909,000 | 1.30% | ||
| 25 | Artal Group S.A. | 200,000 | 1,600,000 | 1.09% | ||
| 26 | NORTHERN TRUST CORP | 176,801 | 1,415,000 | 0.96% | ||
| 27 | BlackRock Institutional Trust Company, N.A. | 170,320 | 1,363,000 | 0.93% | ||
| 28 | Cormorant Asset Management, LP | 156,741 | 1,254,000 | 0.85% | ||
| 29 | Foresite Capital Management II, LLC | 156,741 | 1,254,000 | 0.85% | ||
| 30 | GOLDMAN SACHS GROUP INC | 130,902 | 1,047,000 | 0.71% | ||
| 31 | BlackRock Investment Management, LLC | 83,889 | 671,000 | 0.46% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 70,571 | 564,000 | 0.38% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 62,793 | 502,000 | 0.34% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 59,859 | 479,000 | 0.33% | ||
| 35 | VHCP Management, LLC | 52,500 | 420,000 | 0.29% | ||
| 36 | TFS CAPITAL LLC | 51,877 | 415,000 | 0.28% | ||
| 37 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 50,000 | 400,000 | 0.27% | ||
| 38 | Bank of New York Mellon Corp | 43,740 | 350,000 | 0.24% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,475 | 340,000 | 0.23% | ||
| 40 | GRATICULE ASIA MACRO ADVISORS LLC | 41,500 | 332,000 | 0.23% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,778 | 327,000 | 0.22% | ||
| 42 | TEACHERS ADVISORS, LLC | 32,782 | 262,000 | 0.18% | ||
| 43 | DEUTSCHE BANK AG\ | 30,897 | 246,000 | 0.17% | ||
| 44 | STRS OHIO | 29,600 | 236,000 | 0.16% | ||
| 45 | A.R.T. Advisors, LLC | 27,600 | 220,000 | 0.15% | ||
| 46 | TD ASSET MANAGEMENT INC | 23,165 | 185,000 | 0.13% | ||
| 47 | NEW YORK STATE COMMON RETIREMENT FUND | 20,900 | 167,000 | 0.11% | ||
| 48 | FRED ALGER MANAGEMENT, LLC | 20,000 | 160,000 | 0.11% | ||
| 49 | RHUMBLINE ADVISERS | 18,508 | 148,000 | 0.10% | ||
| 50 | BANK OF AMERICA CORP /DE/ | 18,359 | 147,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
