| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BlackRock Finance, Inc. | 2,380,591 | 45,945,000 | 11.45% | ||
| 2 | FMR LLC | 2,274,594 | 43,900,000 | 10.94% | ||
| 3 | Bain Capital Public Equity Management, LLC | 1,893,311 | 36,541,000 | 9.10% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 1,396,244 | 26,947,000 | 6.71% | ||
| 5 | Redmile Group, LLC | 1,269,131 | 24,494,000 | 6.10% | ||
| 6 | RTW INVESTMENTS, LP | 1,216,505 | 23,479,000 | 5.85% | ||
| 7 | JPMORGAN CHASE & CO | 1,175,794 | 22,693,000 | 5.65% | ||
| 8 | VANGUARD GROUP INC | 981,517 | 18,942,000 | 4.72% | ||
| 9 | FRANKLIN RESOURCES INC | 973,200 | 18,783,000 | 4.68% | ||
| 10 | PFM Health Sciences, LP | 798,247 | 15,406,000 | 3.84% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 742,237 | 14,325,000 | 3.57% | ||
| 12 | CITADEL ADVISORS LLC | 559,887 | 10,806,000 | 2.69% | ||
| 13 | Invesco Ltd. | 415,277 | 8,016,000 | 2.00% | ||
| 14 | Weiss Multi-Strategy Advisers LLC | 405,204 | 7,820,000 | 1.95% | ||
| 15 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 325,000 | 6,273,000 | 1.56% | ||
| 16 | STATE STREET CORP | 316,715 | 6,114,000 | 1.52% | ||
| 17 | FIL Ltd | 302,198 | 5,832,000 | 1.45% | ||
| 18 | AXA S.A. | 226,195 | 4,366,000 | 1.09% | ||
| 19 | NORTHERN TRUST CORP | 215,982 | 4,169,000 | 1.04% | ||
| 20 | QVT Financial LP | 193,432 | 3,733,000 | 0.93% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 171,346 | 3,306,000 | 0.82% | ||
| 22 | VIVO CAPITAL, LLC | 164,403 | 3,173,000 | 0.79% | ||
| 23 | Artal Group S.A. | 160,000 | 3,088,000 | 0.77% | ||
| 24 | Informed Momentum Co LLC | 150,086 | 2,897,000 | 0.72% | ||
| 25 | Bank of New York Mellon Corp | 146,552 | 2,828,000 | 0.70% | ||
| 26 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 133,410 | 2,575,000 | 0.64% | ||
| 27 | Cormorant Asset Management, LP | 120,000 | 2,316,000 | 0.58% | ||
| 28 | DEUTSCHE BANK AG\ | 110,306 | 2,125,000 | 0.53% | ||
| 29 | MONASHEE INVESTMENT MANAGEMENT LLC | 90,000 | 1,737,000 | 0.43% | PRN | |
| 30 | SCHONFELD STRATEGIC ADVISORS LLC | 76,911 | 1,485,000 | 0.37% | ||
| 31 | Mirae Asset Global Investments Co., Ltd. | 75,591 | 1,459,000 | 0.36% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 73,724 | 1,423,000 | 0.35% | ||
| 33 | CASTLE HOOK PARTNERS LP | 60,000 | 1,158,000 | 0.29% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,528 | 1,072,000 | 0.27% | ||
| 35 | AMERIPRISE FINANCIAL INC | 52,163 | 1,006,000 | 0.25% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 51,380 | 992,000 | 0.25% | ||
| 37 | GMT CAPITAL CORP | 51,400 | 992,000 | 0.25% | ||
| 38 | TUDOR INVESTMENT CORP ET AL | 50,730 | 979,000 | 0.24% | ||
| 39 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 50,000 | 965,000 | 0.24% | ||
| 40 | GRATICULE ASIA MACRO ADVISORS LLC | 49,150 | 949,000 | 0.24% | ||
| 41 | VICTORY CAPITAL MANAGEMENT INC | 46,969 | 907,000 | 0.23% | ||
| 42 | Nationwide Fund Advisors | 45,955 | 887,000 | 0.22% | ||
| 43 | Swiss National Bank | 42,600 | 822,000 | 0.20% | ||
| 44 | MORGAN STANLEY | 42,506 | 821,000 | 0.20% | ||
| 45 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 40,928 | 790,000 | 0.20% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,875 | 770,000 | 0.19% | ||
| 47 | ArchPoint Investors | 37,000 | 714,000 | 0.18% | ||
| 48 | TEACHERS ADVISORS, LLC | 35,351 | 682,000 | 0.17% | ||
| 49 | GOLDMAN SACHS GROUP INC | 35,300 | 681,000 | 0.17% | ||
| 50 | STRS OHIO | 32,900 | 634,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
