| 1 |
FRANKLIN RESOURCES INC |
2,663,123 |
27,324,000 |
17.48% |
|
|
| 2 |
New Leaf Venture Partners, L.L.C. |
2,344,868 |
24,058,000 |
15.39% |
|
|
| 3 |
JANUS HENDERSON GROUP PLC |
2,140,549 |
21,962,000 |
14.05% |
|
|
| 4 |
VHCP MANAGEMENT II, LLC |
1,933,582 |
19,839,000 |
12.69% |
|
|
| 5 |
ACUTA CAPITAL PARTNERS, LLC |
1,504,612 |
15,437,000 |
9.88% |
|
|
| 6 |
EAGLE ASSET MANAGEMENT INC |
901,359 |
9,247,000 |
5.92% |
|
|
| 7 |
BlackRock Finance, Inc. |
891,872 |
9,151,000 |
5.86% |
|
|
| 8 |
VANGUARD GROUP INC |
681,050 |
6,988,000 |
4.47% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
319,564 |
3,279,000 |
2.10% |
|
|
| 10 |
STATE STREET CORP |
277,352 |
2,847,000 |
1.82% |
|
|
| 11 |
GEODE CAPITAL MANAGEMENT, LLC |
183,008 |
1,877,000 |
1.20% |
|
|
| 12 |
SPHERA FUNDS MANAGEMENT LTD. |
150,000 |
1,539,000 |
0.98% |
|
|
| 13 |
REGENTATLANTIC CAPITAL LLC |
134,900 |
1,384,000 |
0.89% |
|
|
| 14 |
Opaleye Management Inc. |
130,000 |
1,334,000 |
0.85% |
|
|
| 15 |
NORTHERN TRUST CORP |
119,700 |
1,229,000 |
0.79% |
|
|
| 16 |
JPMORGAN CHASE & CO |
117,225 |
1,203,000 |
0.77% |
|
|
| 17 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
75,279 |
773,000 |
0.49% |
|
|
| 18 |
RENAISSANCE TECHNOLOGIES LLC |
60,800 |
624,000 |
0.40% |
|
|
| 19 |
Bank of New York Mellon Corp |
57,902 |
594,000 |
0.38% |
|
|
| 20 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
50,210 |
515,000 |
0.33% |
|
|
| 21 |
FMR LLC |
50,015 |
513,000 |
0.33% |
|
|
| 22 |
Raymond James Financial Services Advisors, Inc. |
48,000 |
492,000 |
0.31% |
|
|
| 23 |
GOLDMAN SACHS GROUP INC |
36,487 |
374,000 |
0.24% |
|
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
35,167 |
361,000 |
0.23% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
34,329 |
352,000 |
0.23% |
|
|
| 26 |
MORGAN STANLEY |
27,695 |
284,000 |
0.18% |
|
|
| 27 |
D. E. Shaw & Co., Inc. |
23,020 |
236,000 |
0.15% |
|
|
| 28 |
SG Americas Securities, LLC |
22,989 |
236,000 |
0.15% |
|
|
| 29 |
DEUTSCHE BANK AG\ |
21,862 |
223,000 |
0.14% |
|
|
| 30 |
TFS CAPITAL LLC |
20,080 |
206,000 |
0.13% |
|
|
| 31 |
RHUMBLINE ADVISERS |
19,960 |
205,000 |
0.13% |
|
|
| 32 |
DAFNA Capital Management LLC |
19,400 |
199,000 |
0.13% |
|
|
| 33 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
18,114 |
186,000 |
0.12% |
|
|
| 34 |
NEW YORK STATE COMMON RETIREMENT FUND |
17,300 |
177,000 |
0.11% |
|
|
| 35 |
STATE OF WISCONSIN INVESTMENT BOARD |
15,000 |
154,000 |
0.10% |
|
|
| 36 |
MARK SHEPTOFF FINANCIAL PLANNING, LLC |
14,400 |
148,000 |
0.09% |
|
|
| 37 |
AMERICAN INTERNATIONAL GROUP, INC. |
12,322 |
126,000 |
0.08% |
|
|
| 38 |
WELLS FARGO & COMPANY/MN |
11,942 |
123,000 |
0.08% |
|
|
| 39 |
RUSSELL INVESTMENTS GROUP, LTD. |
11,959 |
123,000 |
0.08% |
|
|
| 40 |
VOYA INVESTMENT MANAGEMENT LLC |
10,284 |
106,000 |
0.07% |
|
|
| 41 |
Nationwide Fund Advisors |
9,269 |
95,000 |
0.06% |
|
|
| 42 |
Legal & General Group Plc |
4,056 |
42,000 |
0.03% |
|
|
| 43 |
ROYAL BANK OF CANADA |
2,521 |
25,000 |
0.02% |
|
|
| 44 |
BNP PARIBAS FINANCIAL MARKETS |
1,934 |
19,843 |
0.01% |
|
|
| 45 |
Ameritas Investment Partners, Inc. |
1,743 |
18,000 |
0.01% |
|
|
| 46 |
Tower Research Capital LLC (TRC) |
1,191 |
12,000 |
0.01% |
|
|
| 47 |
PARK CIRCLE Co |
1,200 |
12,000 |
0.01% |
|
|
| 48 |
STRS OHIO |
1,000 |
10,000 |
0.01% |
|
|
| 49 |
ADVANTAGE INVESTMENT MANAGEMENT, LLC |
900 |
9,000 |
0.01% |
|
|
| 50 |
PANAGORA ASSET MANAGEMENT INC |
827 |
8,000 |
0.01% |
|
|
