| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 2,428,571 | 7,699,000 | 21.00% | ||
| 2 | FMR LLC | 2,349,710 | 7,449,000 | 20.32% | ||
| 3 | RTW INVESTMENTS, LP | 2,078,991 | 6,590,000 | 17.98% | ||
| 4 | 683 Capital Management, LLC | 800,000 | 2,536,000 | 6.92% | ||
| 5 | EcoR1 Capital, LLC | 767,992 | 2,435,000 | 6.64% | ||
| 6 | Palo Alto Investors LP | 500,913 | 1,588,000 | 4.33% | ||
| 7 | RENAISSANCE TECHNOLOGIES LLC | 443,100 | 1,405,000 | 3.83% | ||
| 8 | EVENTIDE ASSET MANAGEMENT, LLC | 377,000 | 1,195,000 | 3.26% | ||
| 9 | VANGUARD GROUP INC | 340,327 | 1,078,000 | 2.94% | ||
| 10 | UBS Group AG | 283,933 | 900,000 | 2.46% | ||
| 11 | Omega Fund Management, LLC | 223,457 | 708,000 | 1.93% | ||
| 12 | SABBY MANAGEMENT, LLC | 190,000 | 602,000 | 1.64% | ||
| 13 | Paloma Partners Management Co | 160,000 | 507,000 | 1.38% | ||
| 14 | BlackRock Finance, Inc. | 115,065 | 364,000 | 0.99% | ||
| 15 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 93,300 | 296,000 | 0.81% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 82,690 | 262,000 | 0.71% | ||
| 17 | Connor, Clark & Lunn Investment Management Ltd. | 79,275 | 251,000 | 0.68% | ||
| 18 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 41,000 | 130,000 | 0.35% | ||
| 19 | BOURGEON CAPITAL MANAGEMENT LLC | 39,000 | 124,000 | 0.34% | ||
| 20 | NORTHERN TRUST CORP | 36,219 | 114,000 | 0.31% | ||
| 21 | DIMENSIONAL FUND ADVISORS LP | 32,024 | 102,000 | 0.28% | ||
| 22 | Bank of New York Mellon Corp | 28,564 | 91,000 | 0.25% | ||
| 23 | Birchview Capital, LP | 20,000 | 63,000 | 0.17% | SH | |
| 24 | Quotient Investors, LLC | 19,300 | 61,000 | 0.17% | ||
| 25 | TFS CAPITAL LLC | 14,518 | 46,000 | 0.13% | ||
| 26 | Creative Planning | 7,611 | 24,000 | 0.07% | ||
| 27 | PANAGORA ASSET MANAGEMENT INC | 5,244 | 17,000 | 0.05% | ||
| 28 | JPMORGAN CHASE & CO | 3,370 | 11,000 | 0.03% | ||
| 29 | MORGAN STANLEY | 1,246 | 4,000 | 0.01% | ||
| 30 | QS Investors, LLC | 1,071 | 3,000 | 0.01% | ||
| 31 | FEDERATED HERMES, INC. | 541 | 2,000 | 0.01% | ||
| 32 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 642 | 2,000 | 0.01% | ||
| 33 | BNP PARIBAS FINANCIAL MARKETS | 32 | 101 | 0.00% | ||
| 34 | BARCLAYS PLC | 78 | 0 | 0.00% | ||
| 35 | WELLS FARGO & COMPANY/MN | 140 | 0 | 0.00% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 35 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
