| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 1,783,131 | 29,333,000 | 27.09% | ||
| 2 | JENNISON ASSOCIATES LLC | 729,799 | 12,005,000 | 11.09% | ||
| 3 | Capital World Investors | 722,200 | 11,880,000 | 10.97% | ||
| 4 | Redmile Group, LLC | 493,183 | 8,113,000 | 7.49% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 450,000 | 7,403,000 | 6.84% | ||
| 6 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 400,900 | 6,591,000 | 6.09% | ||
| 7 | JPMORGAN CHASE & CO | 328,075 | 5,397,000 | 4.98% | ||
| 8 | Visium Asset Management, LP | 287,000 | 4,722,000 | 4.36% | ||
| 9 | Broadfin Capital, LLC | 263,204 | 4,330,000 | 4.00% | ||
| 10 | FMR LLC | 170,606 | 2,806,000 | 2.59% | ||
| 11 | WALL STREET ASSOCIATES | 150,000 | 2,467,000 | 2.28% | ||
| 12 | Opaleye Management Inc. | 135,500 | 2,229,000 | 2.06% | ||
| 13 | BlackRock Fund Advisors | 124,107 | 2,042,000 | 1.89% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 103,955 | 1,710,000 | 1.58% | ||
| 15 | Iguana Healthcare Management, LLC | 90,000 | 1,481,000 | 1.37% | ||
| 16 | FARALLON CAPITAL MANAGEMENT LLC | 50,000 | 823,000 | 0.76% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 42,066 | 692,000 | 0.64% | ||
| 18 | Ghost Tree Capital, LLC | 40,000 | 658,000 | 0.61% | ||
| 19 | SOROS FUND MANAGEMENT LLC | 30,000 | 494,000 | 0.46% | ||
| 20 | STATE STREET CORP | 28,668 | 472,000 | 0.44% | ||
| 21 | SAC Capital Advisors LP | 23,769 | 391,000 | 0.36% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 21,025 | 345,000 | 0.32% | ||
| 23 | NORTHERN TRUST CORP | 20,694 | 341,000 | 0.31% | ||
| 24 | Nationwide Fund Advisors | 19,687 | 324,000 | 0.30% | ||
| 25 | BlackRock Investment Management, LLC | 11,039 | 182,000 | 0.17% | ||
| 26 | Bank of New York Mellon Corp | 10,212 | 168,000 | 0.16% | ||
| 27 | CREDIT SUISSE AG/ | 10,074 | 166,000 | 0.15% | ||
| 28 | Spark Investment Management LLC | 10,100 | 166,000 | 0.15% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,200 | 135,000 | 0.12% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 7,750 | 127,000 | 0.12% | ||
| 31 | BANK OF AMERICA CORP /DE/ | 5,000 | 82,000 | 0.08% | ||
| 32 | TEACHERS ADVISORS, LLC | 4,590 | 76,000 | 0.07% | ||
| 33 | WELLS FARGO & COMPANY/MN | 2,624 | 43,000 | 0.04% | ||
| 34 | BARCLAYS PLC | 1,923 | 31,000 | 0.03% | ||
| 35 | DEUTSCHE BANK AG\ | 1,113 | 17,000 | 0.02% | ||
| 36 | BLACKROCK ADVISORS LLC | 1,042 | 17,000 | 0.02% | ||
| 37 | MORGAN STANLEY | 577 | 9,000 | 0.01% | ||
| 38 | Tower Research Capital LLC (TRC) | 257 | 4,000 | 0.00% | ||
| 39 | UBS AG | 211 | 3,000 | 0.00% | ||
| 40 | CITIGROUP INC | 22 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
