| 1 |
Novo Holdings A/S |
1,783,131 |
32,560,000 |
29.60% |
|
|
| 2 |
Capital World Investors |
979,252 |
17,881,000 |
16.25% |
|
|
| 3 |
JENNISON ASSOCIATES LLC |
860,834 |
15,719,000 |
14.29% |
|
|
| 4 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
573,357 |
10,469,000 |
9.52% |
|
|
| 5 |
Visium Asset Management, LP |
496,000 |
9,057,000 |
8.23% |
|
|
| 6 |
Redmile Group, LLC |
465,933 |
8,508,000 |
7.73% |
|
|
| 7 |
Broadfin Capital, LLC |
213,204 |
3,893,000 |
3.54% |
|
|
| 8 |
WALL STREET ASSOCIATES |
150,000 |
2,739,000 |
2.49% |
|
|
| 9 |
BlackRock Fund Advisors |
110,080 |
2,010,000 |
1.83% |
|
|
| 10 |
STATE STREET CORP |
58,646 |
1,071,000 |
0.97% |
|
|
| 11 |
NORTHERN TRUST CORP |
50,587 |
923,000 |
0.84% |
|
|
| 12 |
Iguana Healthcare Management, LLC |
50,000 |
913,000 |
0.83% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
37,488 |
685,000 |
0.62% |
|
|
| 14 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
30,000 |
548,000 |
0.50% |
|
|
| 15 |
VANGUARD GROUP INC |
29,742 |
543,000 |
0.49% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
25,664 |
468,000 |
0.43% |
|
|
| 17 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,391 |
354,000 |
0.32% |
|
|
| 18 |
Bank of New York Mellon Corp |
19,198 |
350,000 |
0.32% |
|
|
| 19 |
BlackRock Investment Management, LLC |
13,291 |
243,000 |
0.22% |
|
|
| 20 |
Ghost Tree Capital, LLC |
12,488 |
228,000 |
0.21% |
|
|
| 21 |
MORGAN STANLEY |
11,886 |
218,000 |
0.20% |
|
|
| 22 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8,348 |
152,000 |
0.14% |
|
|
| 23 |
TEACHERS ADVISORS, LLC |
6,505 |
119,000 |
0.11% |
|
|
| 24 |
Nationwide Fund Advisors |
3,556 |
65,000 |
0.06% |
|
|
| 25 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,454 |
63,071 |
0.06% |
|
|
| 26 |
BLACKROCK ADVISORS LLC |
1,904 |
35,000 |
0.03% |
|
|
| 27 |
NEXT Financial Group, Inc |
1,900 |
35,000 |
0.03% |
|
|
| 28 |
Tower Research Capital LLC (TRC) |
1,760 |
32,000 |
0.03% |
|
|
| 29 |
STRS OHIO |
1,700 |
31,000 |
0.03% |
|
|
| 30 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,143 |
21,000 |
0.02% |
|
|
| 31 |
UBS AG |
1,122 |
20,000 |
0.02% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
889 |
16,000 |
0.01% |
|
|
| 33 |
ALLIANCEBERNSTEIN L.P. |
700 |
13,000 |
0.01% |
|
|
| 34 |
BNP PARIBAS FINANCIAL MARKETS |
464 |
8,473 |
0.01% |
|
|
| 35 |
WELLS FARGO & COMPANY/MN |
439 |
8,000 |
0.01% |
|
|
| 36 |
CITIGROUP INC |
207 |
4,000 |
0.00% |
|
|
| 37 |
BARCLAYS PLC |
148 |
3,000 |
0.00% |
|
|
| 38 |
DEUTSCHE BANK AG\ |
37 |
0 |
0.00% |
|
|
