| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 2,831,268 | 42,073,000 | 17.16% | ||
| 2 | GILDER GAGNON HOWE & CO LLC | 2,272,009 | 33,762,000 | 13.77% | ||
| 3 | Capital World Investors | 1,703,194 | 25,309,000 | 10.32% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,258,714 | 18,704,000 | 7.63% | ||
| 5 | Novo Holdings A/S | 1,033,131 | 15,352,000 | 6.26% | ||
| 6 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 835,725 | 12,419,000 | 5.06% | ||
| 7 | DRIEHAUS CAPITAL MANAGEMENT LLC | 783,371 | 11,641,000 | 4.75% | ||
| 8 | WASATCH ADVISORS LP | 502,992 | 7,474,000 | 3.05% | ||
| 9 | VANGUARD GROUP INC | 437,001 | 6,494,000 | 2.65% | ||
| 10 | Invesco Ltd. | 404,778 | 6,015,000 | 2.45% | ||
| 11 | SCHRODER INVESTMENT MANAGEMENT GROUP | 388,700 | 5,776,000 | 2.36% | ||
| 12 | WELLS FARGO & COMPANY/MN | 370,679 | 5,508,000 | 2.25% | ||
| 13 | BlackRock Fund Advisors | 365,843 | 5,436,000 | 2.22% | ||
| 14 | ALPS ADVISORS INC | 33,656 | 5,001,000 | 2.04% | ||
| 15 | Broadfin Capital, LLC | 323,188 | 4,803,000 | 1.96% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 267,889 | 3,981,000 | 1.62% | ||
| 17 | BARCLAYS PLC | 225,000 | 3,150,000 | 1.28% | Call | |
| 18 | WALL STREET ASSOCIATES | 187,100 | 2,780,000 | 1.13% | ||
| 19 | NORTHERN TRUST CORP | 173,934 | 2,585,000 | 1.05% | ||
| 20 | STATE STREET CORP | 171,951 | 2,554,000 | 1.04% | ||
| 21 | MORGAN STANLEY | 156,536 | 2,326,000 | 0.95% | ||
| 22 | MARSHALL WACE, LLP | 132,945 | 1,976,000 | 0.81% | ||
| 23 | Visium Asset Management, LP | 123,492 | 1,835,000 | 0.75% | ||
| 24 | GAM Holding AG | 96,300 | 1,431,000 | 0.58% | ||
| 25 | Segantii Capital Management Ltd | 75,400 | 1,088,000 | 0.44% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 71,959 | 1,069,000 | 0.44% | ||
| 27 | Allianz Asset Management GmbH | 68,376 | 1,016,000 | 0.41% | ||
| 28 | GREAT POINT PARTNERS LLC | 66,300 | 985,000 | 0.40% | Call | |
| 29 | D. E. Shaw & Co., Inc. | 50,925 | 757,000 | 0.31% | ||
| 30 | AQR CAPITAL MANAGEMENT LLC | 50,314 | 748,000 | 0.31% | ||
| 31 | NORGES BANK | 50,000 | 743,000 | 0.30% | ||
| 32 | BlackRock Investment Management, LLC | 49,200 | 731,000 | 0.30% | ||
| 33 | MACQUARIE GROUP LTD | 47,534 | 706,000 | 0.29% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 45,899 | 682,000 | 0.28% | ||
| 35 | DEUTSCHE BANK AG\ | 44,427 | 660,000 | 0.27% | ||
| 36 | Bank of New York Mellon Corp | 44,253 | 657,000 | 0.27% | ||
| 37 | ROYAL BANK OF CANADA | 34,444 | 512,000 | 0.21% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,300 | 510,000 | 0.21% | Call | |
| 39 | JANE STREET GROUP, LLC | 32,593 | 484,000 | 0.20% | ||
| 40 | RUSSELL FRANK CO/ | 28,562 | 424,000 | 0.17% | ||
| 41 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25,740 | 382,000 | 0.16% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,307 | 376,000 | 0.15% | ||
| 43 | BLACKROCK ADVISORS LLC | 25,121 | 373,000 | 0.15% | ||
| 44 | Nationwide Fund Advisors | 24,928 | 370,000 | 0.15% | ||
| 45 | Cubist Systematic Strategies, LLC | 22,710 | 337,000 | 0.14% | ||
| 46 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 20,753 | 308,000 | 0.13% | ||
| 47 | TEACHERS ADVISORS, LLC | 20,429 | 304,000 | 0.12% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,943 | 297,000 | 0.12% | ||
| 49 | MILLENNIUM MANAGEMENT LLC | 19,840 | 295,000 | 0.12% | ||
| 50 | DUPONT CAPITAL MANAGEMENT CORP | 19,491 | 290,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
