| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GILDER GAGNON HOWE & CO LLC | 2,292,467 | 51,626,000 | 19.21% | ||
| 2 | Novo Holdings A/S | 2,283,131 | 51,416,000 | 19.13% | ||
| 3 | JENNISON ASSOCIATES LLC | 2,003,413 | 45,117,000 | 16.79% | ||
| 4 | Capital World Investors | 1,419,252 | 31,962,000 | 11.89% | ||
| 5 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,031,640 | 23,233,000 | 8.64% | ||
| 6 | Broadfin Capital, LLC | 348,204 | 7,842,000 | 2.92% | ||
| 7 | Visium Asset Management, LP | 270,872 | 6,100,000 | 2.27% | ||
| 8 | SCHRODER INVESTMENT MANAGEMENT GROUP | 264,900 | 5,928,000 | 2.21% | ||
| 9 | VANGUARD GROUP INC | 208,370 | 4,693,000 | 1.75% | ||
| 10 | WELLS FARGO & COMPANY/MN | 195,912 | 4,412,000 | 1.64% | ||
| 11 | Redmile Group, LLC | 189,624 | 4,270,000 | 1.59% | ||
| 12 | WALL STREET ASSOCIATES | 187,100 | 4,213,000 | 1.57% | ||
| 13 | BlackRock Fund Advisors | 171,290 | 3,857,000 | 1.44% | ||
| 14 | EcoR1 Capital, LLC | 162,900 | 3,669,000 | 1.37% | ||
| 15 | STATE STREET CORP | 75,307 | 1,699,000 | 0.63% | ||
| 16 | GAM Holding AG | 75,400 | 1,698,000 | 0.63% | ||
| 17 | NORTHERN TRUST CORP | 73,240 | 1,649,000 | 0.61% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 60,536 | 1,363,000 | 0.51% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 58,631 | 1,320,000 | 0.49% | ||
| 20 | SMITH ASSET MANAGEMENT GROUP LP | 51,400 | 1,158,000 | 0.43% | ||
| 21 | Iguana Healthcare Management, LLC | 50,000 | 1,126,000 | 0.42% | ||
| 22 | Informed Momentum Co LLC | 39,120 | 881,000 | 0.33% | ||
| 23 | TWO SIGMA INVESTMENTS, LP | 34,253 | 771,000 | 0.29% | ||
| 24 | RUSSELL FRANK CO/ | 34,003 | 766,000 | 0.29% | ||
| 25 | Bank of New York Mellon Corp | 31,693 | 714,000 | 0.27% | ||
| 26 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 30,000 | 676,000 | 0.25% | ||
| 27 | RENAISSANCE TECHNOLOGIES LLC | 26,106 | 588,000 | 0.22% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 24,864 | 560,000 | 0.21% | ||
| 29 | Spark Investment Management LLC | 24,600 | 553,000 | 0.21% | ||
| 30 | TFS CAPITAL LLC | 22,877 | 515,000 | 0.19% | ||
| 31 | GOLDMAN SACHS GROUP INC | 20,510 | 462,000 | 0.17% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 19,233 | 433,000 | 0.16% | ||
| 33 | STRS OHIO | 18,635 | 419,000 | 0.16% | ||
| 34 | BlackRock Investment Management, LLC | 17,558 | 395,000 | 0.15% | ||
| 35 | PNC FINANCIAL SERVICES GROUP, INC. | 16,143 | 364,000 | 0.14% | ||
| 36 | SHEPHERD KAPLAN KROCHUK, LLC | 14,378 | 324,000 | 0.12% | ||
| 37 | DEUTSCHE BANK AG\ | 11,647 | 262,000 | 0.10% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,184 | 252,000 | 0.09% | ||
| 39 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 9,745 | 219,000 | 0.08% | ||
| 40 | MORGAN STANLEY | 9,551 | 215,000 | 0.08% | ||
| 41 | Cubist Systematic Strategies, LLC | 9,207 | 207,000 | 0.08% | ||
| 42 | TEACHERS ADVISORS, LLC | 8,694 | 196,000 | 0.07% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 5,060 | 113,951 | 0.04% | ||
| 44 | CITIGROUP INC | 4,830 | 109,000 | 0.04% | ||
| 45 | Nationwide Fund Advisors | 4,471 | 101,000 | 0.04% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 3,500 | 79,000 | 0.03% | ||
| 47 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 3,051 | 68,000 | 0.03% | ||
| 48 | BLACKROCK ADVISORS LLC | 2,945 | 66,000 | 0.02% | ||
| 49 | Tower Research Capital LLC (TRC) | 1,248 | 28,000 | 0.01% | ||
| 50 | ROYAL BANK OF CANADA | 1,000 | 23,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
