| 1 |
Novo Holdings A/S |
1,783,131 |
24,037,000 |
29.46% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
820,677 |
11,063,000 |
13.56% |
|
|
| 3 |
Capital World Investors |
750,000 |
10,110,000 |
12.39% |
|
|
| 4 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
514,466 |
6,909,000 |
8.47% |
|
|
| 5 |
Redmile Group, LLC |
504,083 |
6,795,000 |
8.33% |
|
|
| 6 |
Visium Asset Management, LP |
500,000 |
6,740,000 |
8.26% |
|
|
| 7 |
JPMORGAN CHASE & CO |
271,676 |
3,662,000 |
4.49% |
|
|
| 8 |
Broadfin Capital, LLC |
263,204 |
3,548,000 |
4.35% |
|
|
| 9 |
WALL STREET ASSOCIATES |
150,000 |
2,022,000 |
2.48% |
|
|
| 10 |
BlackRock Fund Advisors |
114,858 |
1,548,000 |
1.90% |
|
|
| 11 |
Iguana Healthcare Management, LLC |
50,000 |
674,000 |
0.83% |
|
|
| 12 |
STATE STREET CORP |
49,911 |
673,000 |
0.82% |
|
|
| 13 |
NORTHERN TRUST CORP |
48,790 |
658,000 |
0.81% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
41,736 |
563,000 |
0.69% |
|
|
| 15 |
SOROS FUND MANAGEMENT LLC |
30,000 |
405,000 |
0.50% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
21,295 |
287,000 |
0.35% |
|
|
| 17 |
VANGUARD GROUP INC |
20,603 |
278,000 |
0.34% |
|
|
| 18 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,391 |
261,000 |
0.32% |
|
|
| 19 |
Bank of New York Mellon Corp |
19,261 |
260,000 |
0.32% |
|
|
| 20 |
BlackRock Investment Management, LLC |
13,537 |
182,000 |
0.22% |
|
|
| 21 |
Spark Investment Management LLC |
10,200 |
136,000 |
0.17% |
|
|
| 22 |
BANQUE PICTET & CIE SA |
10,035 |
135,000 |
0.17% |
|
|
| 23 |
Nationwide Fund Advisors |
9,756 |
132,000 |
0.16% |
|
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8,200 |
111,000 |
0.14% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
6,505 |
88,000 |
0.11% |
|
|
| 26 |
PARADIGM ASSET MANAGEMENT CO LLC |
4,950 |
66,726 |
0.08% |
|
|
| 27 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,830 |
51,628 |
0.06% |
|
|
| 28 |
BLACKROCK ADVISORS LLC |
1,904 |
26,000 |
0.03% |
|
|
| 29 |
MORGAN STANLEY |
1,882 |
26,000 |
0.03% |
|
|
| 30 |
NEXT Financial Group, Inc |
1,900 |
25,000 |
0.03% |
|
|
| 31 |
WELLS FARGO & COMPANY/MN |
1,454 |
20,000 |
0.02% |
|
|
| 32 |
UBS AG |
1,403 |
19,000 |
0.02% |
|
|
| 33 |
Tower Research Capital LLC (TRC) |
1,189 |
16,000 |
0.02% |
|
|
| 34 |
ALLIANCEBERNSTEIN L.P. |
1,000 |
13,000 |
0.02% |
|
|
| 35 |
BANK OF MONTREAL /CAN/ |
920 |
12,000 |
0.01% |
|
|
| 36 |
BARCLAYS PLC |
822 |
11,000 |
0.01% |
|
|
| 37 |
DEUTSCHE BANK AG\ |
607 |
8,000 |
0.01% |
|
|
| 38 |
Ground Swell Capital, LLC |
549 |
7,000 |
0.01% |
|
|
| 39 |
BNP PARIBAS FINANCIAL MARKETS |
389 |
5,244 |
0.01% |
|
|
| 40 |
VIRTUS CAPITAL ADVISERS, LLC |
388 |
5,000 |
0.01% |
|
|
| 41 |
BANK OF AMERICA CORP /DE/ |
372 |
5,000 |
0.01% |
|
|
| 42 |
CITIGROUP INC |
38 |
1,000 |
0.00% |
|
|
