| 1 |
Novo Holdings A/S |
2,283,131 |
46,096,000 |
19.36% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
1,747,825 |
35,289,000 |
14.82% |
|
|
| 3 |
GILDER GAGNON HOWE & CO LLC |
1,573,848 |
31,776,000 |
13.34% |
|
|
| 4 |
Capital World Investors |
1,419,252 |
29,222,000 |
12.27% |
|
|
| 5 |
FMR LLC |
1,303,587 |
26,319,000 |
11.05% |
|
|
| 6 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
1,037,489 |
20,947,000 |
8.80% |
|
|
| 7 |
Broadfin Capital, LLC |
413,204 |
8,343,000 |
3.50% |
|
|
| 8 |
Visium Asset Management, LP |
350,000 |
7,067,000 |
2.97% |
|
|
| 9 |
Redmile Group, LLC |
315,144 |
6,363,000 |
2.67% |
|
|
| 10 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
260,000 |
5,249,000 |
2.20% |
|
|
| 11 |
BlackRock Fund Advisors |
164,259 |
3,316,000 |
1.39% |
|
|
| 12 |
WALL STREET ASSOCIATES |
150,000 |
3,028,000 |
1.27% |
|
|
| 13 |
VANGUARD GROUP INC |
126,057 |
2,545,000 |
1.07% |
|
|
| 14 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
99,847 |
2,016,000 |
0.85% |
|
|
| 15 |
Iguana Healthcare Management, LLC |
75,000 |
1,514,000 |
0.64% |
|
|
| 16 |
STATE STREET CORP |
63,606 |
1,281,000 |
0.54% |
|
|
| 17 |
NORTHERN TRUST CORP |
61,521 |
1,242,000 |
0.52% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
46,219 |
933,000 |
0.39% |
|
|
| 19 |
TWO SIGMA INVESTMENTS, LP |
41,813 |
844,000 |
0.35% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
34,343 |
693,000 |
0.29% |
|
|
| 21 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
34,250 |
692,000 |
0.29% |
|
|
| 22 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
30,000 |
606,000 |
0.25% |
|
|
| 23 |
TFS CAPITAL LLC |
21,768 |
439,000 |
0.18% |
|
|
| 24 |
Bank of New York Mellon Corp |
20,526 |
414,000 |
0.17% |
|
|
| 25 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
19,233 |
388,000 |
0.16% |
|
|
| 26 |
BlackRock Investment Management, LLC |
16,401 |
331,000 |
0.14% |
|
|
| 27 |
MORGAN STANLEY |
16,369 |
330,000 |
0.14% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
11,184 |
226,000 |
0.09% |
|
|
| 29 |
TEACHERS ADVISORS, LLC |
6,505 |
131,000 |
0.06% |
|
|
| 30 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,360 |
128,408 |
0.05% |
|
|
| 31 |
Nationwide Fund Advisors |
4,296 |
87,000 |
0.04% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
2,904 |
58,000 |
0.02% |
|
|
| 33 |
BLACKROCK ADVISORS LLC |
2,169 |
44,000 |
0.02% |
|
|
| 34 |
Tower Research Capital LLC (TRC) |
2,133 |
43,000 |
0.02% |
|
|
| 35 |
STRS OHIO |
1,700 |
34,000 |
0.01% |
|
|
| 36 |
UBS Group AG |
1,125 |
23,000 |
0.01% |
|
|
| 37 |
CITIGROUP INC |
1,082 |
22,000 |
0.01% |
|
|
| 38 |
BANK OF MONTREAL /CAN/ |
1,100 |
22,000 |
0.01% |
|
|
| 39 |
BARCLAYS PLC |
489 |
10,000 |
0.00% |
|
|
| 40 |
ALLIANCEBERNSTEIN L.P. |
500 |
10,000 |
0.00% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
500 |
10,000 |
0.00% |
|
|
| 42 |
WELLS FARGO & COMPANY/MN |
441 |
9,000 |
0.00% |
|
|
| 43 |
FEDERATED HERMES, INC. |
191 |
4,000 |
0.00% |
|
|
| 44 |
BANK OF AMERICA CORP /DE/ |
100 |
2,000 |
0.00% |
|
|
