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IONIS PHARMACEUTICAL
IONIS PHARMACEUTICAL. Institutional holdings reported to the SEC.

Institutional Holders (2014Q1)
Portfolio Summary: 259 Institutional holders with a total value of $4,718,779,595.
#
Manager Name
Shares
Value ($)
%
Options
Notes
1 FMR LLC 17,549,733 758,324,000 16.07%
2 Artisan Partners Limited Partnership 8,761,769 378,596,000 8.02%
3 VANGUARD GROUP INC 7,786,346 336,448,000 7.13%
4 Clearbridge Investments, LLC 7,344,262 317,346,000 6.73%
5 BB BIOTECH AG 6,301,526 272,289,000 5.77%
6 WADDELL & REED FINANCIAL INC 5,314,900 229,657,000 4.87%
7 BlackRock Fund Advisors 4,383,087 189,393,000 4.01%
8 PRICE T ROWE ASSOCIATES INC /MD/ 3,229,257 139,536,000 2.96%
9 BlackRock Institutional Trust Company, N.A. 3,131,542 135,314,000 2.87%
10 STATE STREET CORP 2,407,833 104,042,000 2.20%
11 FRANKLIN RESOURCES INC 2,109,983 91,172,000 1.93%
12 PINNACLE ASSOCIATES LTD 1,940,664 83,856,000 1.78%
13 JENNISON ASSOCIATES LLC 1,915,544 82,771,000 1.75%
14 NORTHERN TRUST CORP 1,522,627 65,793,000 1.39%
15 COLUMBUS CIRCLE INVESTORS 1,449,342 62,626,000 1.33%
16 TOCQUEVILLE ASSET MANAGEMENT L.P. 1,261,703 54,518,000 1.16%
17 ALLIANCEBERNSTEIN L.P. 1,140,853 49,296,000 1.04%
18 AMERICAN CENTURY COMPANIES INC 1,120,391 48,412,000 1.03%
19 SUSQUEHANNA INTERNATIONAL GROUP, LLP 1,001,000 43,253,000 0.92% Put
20 BLACKROCK ADVISORS LLC 903,885 39,057,000 0.83%
21 SECTORAL ASSET MANAGEMENT INC 882,101 38,116,000 0.81%
22 SCOUT INVESTMENTS, INC. 867,252 37,474,000 0.79%
23 STIFEL FINANCIAL CORP 849,096 36,689,000 0.78%
24 NORGES BANK 752,077 32,497,000 0.69%
25 Apex Capital Management 715,317 30,909,000 0.66%
26 EAGLE ASSET MANAGEMENT INC 688,006 29,728,000 0.63%
27 GEODE CAPITAL MANAGEMENT, LLC 683,586 29,537,000 0.63%
28 DOWLING & YAHNKE LLC 676,298 29,223,000 0.62%
29 Bank of New York Mellon Corp 673,705 29,111,000 0.62%
30 SUSQUEHANNA INTERNATIONAL GROUP, LLP 638,600 27,594,000 0.58% Call
31 WELLS FARGO & COMPANY/MN 637,862 27,563,000 0.58%
32 MANAGED ACCOUNT ADVISORS LLC 565,418 24,432,000 0.52%
33 GOLDMAN SACHS GROUP INC 563,995 24,370,000 0.52%
34 TIAA CREF INVESTMENT MANAGEMENT LLC 563,200 24,336,000 0.52%
35 WELLINGTON MANAGEMENT GROUP LLP 556,434 24,043,000 0.51%
36 BARCLAYS PLC 539,200 23,186,000 0.49% Put
37 GOLDMAN SACHS GROUP INC 523,400 22,616,000 0.48% Put
38 VAN ECK ASSOCIATES CORP 502,288 21,704,000 0.46%
39 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 462,150 19,969,502 0.42%
40 Nuveen Asset Management, LLC 456,112 19,709,000 0.42%
41 PANAGORA ASSET MANAGEMENT INC 437,284 18,895,000 0.40%
42 GOLDMAN SACHS GROUP INC 423,400 18,295,000 0.39% Call
43 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 417,997 18,062,000 0.38%
44 Invesco Ltd. 407,498 17,608,000 0.37%
45 AMERIPRISE FINANCIAL INC 376,647 16,277,000 0.34%
46 DEUTSCHE BANK AG\ 376,102 16,250,000 0.34%
47 ROOSEVELT INVESTMENT GROUP LLC 374,168 16,167,798 0.34%
48 SUSQUEHANNA INTERNATIONAL GROUP, LLP 372,029 16,076,000 0.34%
49 Allianz Asset Management GmbH 359,670 15,541,000 0.33%
50 JPMORGAN CHASE & CO 356,549 15,408,000 0.33%
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From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.