Dark
Light
System
Security
IONIS PHARMACEUTICAL
IONIS PHARMACEUTICAL. Institutional holdings reported to the SEC.

Institutional Holders (2015Q2)
Portfolio Summary: 390 Institutional holders with a total value of $5,850,891,360.
#
Manager Name
Shares
Value ($)
%
Options
Notes
1 FMR LLC 17,650,302 1,015,775,000 17.36%
2 Clearbridge Investments, LLC 9,423,002 542,294,000 9.27%
3 VANGUARD GROUP INC 8,580,350 493,799,000 8.44%
4 BB BIOTECH AG 5,929,426 341,238,000 5.83%
5 WADDELL & REED FINANCIAL INC 5,769,300 332,023,000 5.67%
6 BlackRock Institutional Trust Company, N.A. 3,015,447 173,539,000 2.97%
7 BlackRock Fund Advisors 2,617,963 150,664,000 2.58%
8 STATE STREET CORP 2,500,831 143,929,000 2.46%
9 FRANKLIN RESOURCES INC 1,969,983 113,373,000 1.94%
10 PINNACLE ASSOCIATES LTD 1,828,878 105,252,000 1.80%
11 FIRST TRUST ADVISORS LP 1,779,289 102,398,000 1.75%
12 PRICE T ROWE ASSOCIATES INC /MD/ 1,649,805 94,946,000 1.62%
13 NORTHERN TRUST CORP 1,398,254 80,469,000 1.38%
14 TOCQUEVILLE ASSET MANAGEMENT L.P. 1,226,471 70,583,000 1.21%
15 SUSQUEHANNA INTERNATIONAL GROUP, LLP 1,159,900 66,752,000 1.14% Put
16 DEUTSCHE BANK AG\ 1,062,757 61,158,000 1.05%
17 NORGES BANK 1,059,580 60,979,000 1.04%
18 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 985,631 56,723,000 0.97%
19 Apex Capital Management 980,129 56,406,000 0.96%
20 GOLDMAN SACHS GROUP INC 941,482 54,182,000 0.93%
21 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 934,782 53,796,704 0.92%
22 CREDIT SUISSE AG/ 805,561 46,360,000 0.79%
23 Global Thematic Partners, LLC 802,556 46,189,000 0.79%
24 ALLIANCEBERNSTEIN L.P. 797,958 45,922,000 0.78%
25 GEODE CAPITAL MANAGEMENT, LLC 709,093 40,784,000 0.70%
26 BlackRock Group LTD 696,563 40,088,000 0.69%
27 DOWLING & YAHNKE LLC 676,350 38,924,000 0.67%
28 SUSQUEHANNA INTERNATIONAL GROUP, LLP 633,812 36,476,000 0.62%
29 BLACKROCK ADVISORS LLC 610,134 35,113,000 0.60%
30 STIFEL FINANCIAL CORP 594,447 34,210,000 0.58%
31 Bank of New York Mellon Corp 560,228 32,242,000 0.55%
32 WELLS FARGO & COMPANY/MN 553,328 31,837,000 0.54%
33 WELLINGTON MANAGEMENT GROUP LLP 513,675 29,562,000 0.51%
34 AMERICAN CENTURY COMPANIES INC 478,307 27,527,000 0.47%
35 RAYMOND JAMES & ASSOCIATES 473,755 27,265,000 0.47%
36 PANAGORA ASSET MANAGEMENT INC 468,674 26,972,000 0.46%
37 CAPITAL FUND MANAGEMENT S.A. 466,541 26,849,000 0.46%
38 MANAGED ACCOUNT ADVISORS LLC 449,733 25,883,000 0.44%
39 SUSQUEHANNA INTERNATIONAL GROUP, LLP 447,300 25,742,000 0.44% Call
40 TWO SIGMA INVESTMENTS, LP 436,239 25,106,000 0.43%
41 JANUS HENDERSON INVESTORS US LLC 415,138 23,891,000 0.41%
42 Artal Group S.A. 400,000 23,020,000 0.39%
43 TIAA CREF INVESTMENT MANAGEMENT LLC 397,023 22,849,000 0.39%
44 NEW YORK STATE COMMON RETIREMENT FUND 374,552 21,555,000 0.37%
45 MILLENNIUM MANAGEMENT LLC 368,056 21,182,000 0.36%
46 ROYAL BANK OF CANADA 364,561 20,981,000 0.36%
47 EAGLE ASSET MANAGEMENT INC 349,534 20,115,000 0.34%
48 BANK OF AMERICA CORP /DE/ 336,158 19,346,000 0.33%
49 Invesco Ltd. 322,056 18,534,000 0.32%
50 Sumitomo Mitsui Trust Group, Inc. 315,420 18,152,000 0.31%
Page 1 of 8

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.