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IONIS PHARMACEUTICAL
IONIS PHARMACEUTICAL. Institutional holdings reported to the SEC.

Institutional Holders (2014Q2)
Portfolio Summary: 272 Institutional holders with a total value of $3,695,537,515.
#
Manager Name
Shares
Value ($)
%
Options
Notes
1 FMR LLC 17,549,733 604,588,000 16.36%
2 Clearbridge Investments, LLC 8,239,358 283,846,000 7.68%
3 Artisan Partners Limited Partnership 7,571,076 260,824,000 7.06%
4 VANGUARD GROUP INC 7,269,544 250,436,000 6.78%
5 BB BIOTECH AG 6,706,526 231,040,000 6.25%
6 WADDELL & REED FINANCIAL INC 5,363,800 184,783,000 5.00%
7 BlackRock Fund Advisors 4,133,698 142,406,000 3.85%
8 BlackRock Institutional Trust Company, N.A. 3,209,471 110,566,000 2.99%
9 PRICE T ROWE ASSOCIATES INC /MD/ 2,766,278 95,298,000 2.58%
10 STATE STREET CORP 2,407,618 82,941,000 2.24%
11 FRANKLIN RESOURCES INC 1,951,518 67,230,000 1.82%
12 PINNACLE ASSOCIATES LTD 1,914,942 65,970,000 1.79%
13 TOCQUEVILLE ASSET MANAGEMENT L.P. 1,862,903 64,177,000 1.74%
14 JENNISON ASSOCIATES LLC 1,744,822 60,109,000 1.63%
15 NORTHERN TRUST CORP 1,357,312 46,760,000 1.27%
16 SUSQUEHANNA INTERNATIONAL GROUP, LLP 1,281,700 44,155,000 1.19% Put
17 ALLIANCEBERNSTEIN L.P. 1,107,527 38,154,000 1.03%
18 STIFEL FINANCIAL CORP 1,052,228 36,249,000 0.98%
19 Apex Capital Management 889,545 30,645,000 0.83%
20 Global Thematic Partners, LLC 855,966 29,488,000 0.80%
21 SCOUT INVESTMENTS, INC. 829,698 28,583,000 0.77%
22 SUSQUEHANNA INTERNATIONAL GROUP, LLP 786,460 27,094,000 0.73%
23 GOLDMAN SACHS GROUP INC 776,578 26,754,000 0.72%
24 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 757,997 26,113,000 0.71%
25 NORGES BANK 752,077 25,909,000 0.70%
26 SUSQUEHANNA INTERNATIONAL GROUP, LLP 741,000 25,527,000 0.69% Call
27 Bank of New York Mellon Corp 729,333 25,125,000 0.68%
28 DEUTSCHE BANK AG\ 682,894 23,523,000 0.64%
29 GEODE CAPITAL MANAGEMENT, LLC 681,834 23,489,000 0.64%
30 DOWLING & YAHNKE LLC 676,298 23,298,000 0.63%
31 TIAA CREF INVESTMENT MANAGEMENT LLC 587,888 20,253,000 0.55%
32 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 563,506 19,413,000 0.53%
33 WELLS FARGO & COMPANY/MN 544,551 18,761,000 0.51%
34 AMERICAN CENTURY COMPANIES INC 533,616 18,383,000 0.50%
35 GOLDMAN SACHS GROUP INC 524,800 18,079,000 0.49% Put
36 BLACKROCK ADVISORS LLC 512,505 17,656,000 0.48%
37 PANAGORA ASSET MANAGEMENT INC 468,676 16,146,000 0.44%
38 Nuveen Asset Management, LLC 466,453 16,069,000 0.43%
39 Artal Group S.A. 455,000 15,675,000 0.42%
40 TEACHERS ADVISORS, LLC 453,756 15,632,000 0.42%
41 GOLDMAN SACHS GROUP INC 446,800 15,392,000 0.42% Call
42 COLUMBUS CIRCLE INVESTORS 439,392 15,137,000 0.41%
43 WELLINGTON MANAGEMENT GROUP LLP 438,879 15,119,000 0.41%
44 LORD, ABBETT & CO. LLC 397,685 13,694,000 0.37%
45 MANAGED ACCOUNT ADVISORS LLC 384,663 13,251,000 0.36%
46 RAINIER INVESTMENT MANAGEMENT LLC 376,730 12,979,000 0.35%
47 Invesco Ltd. 375,944 12,951,000 0.35%
48 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 344,459 11,867,000 0.32%
49 BlackRock Investment Management, LLC 335,453 11,556,000 0.31%
50 WILLIAM HARRIS INVESTORS INC 329,034 11,335,000 0.31%
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From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.