| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 7,752,487 | 68,377,000 | 49.27% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 1,691,977 | 14,923,000 | 10.75% | ||
| 3 | Visium Asset Management, LP | 1,301,617 | 11,480,000 | 8.27% | ||
| 4 | FRANKLIN RESOURCES INC | 1,245,945 | 10,989,000 | 7.92% | ||
| 5 | GOLDMAN SACHS GROUP INC | 970,317 | 8,558,000 | 6.17% | ||
| 6 | BOXER CAPITAL, LLC | 820,015 | 7,233,000 | 5.21% | ||
| 7 | BLACKROCK ADVISORS LLC | 396,295 | 3,495,000 | 2.52% | ||
| 8 | BlackRock Fund Advisors | 224,716 | 1,982,000 | 1.43% | ||
| 9 | BlackRock Group LTD | 200,100 | 1,765,000 | 1.27% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 199,657 | 1,761,000 | 1.27% | ||
| 11 | Cormorant Asset Management, LP | 150,000 | 1,323,000 | 0.95% | ||
| 12 | Alyeska Investment Group, L.P. | 115,574 | 1,019,000 | 0.73% | ||
| 13 | VANGUARD GROUP INC | 108,332 | 955,000 | 0.69% | ||
| 14 | ROYCE & ASSOCIATES LP | 96,167 | 848,000 | 0.61% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 62,949 | 555,000 | 0.40% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 59,600 | 526,000 | 0.38% | ||
| 17 | MORGAN STANLEY | 59,501 | 525,000 | 0.38% | ||
| 18 | BlackRock Finance, Inc. | 50,600 | 446,000 | 0.32% | ||
| 19 | DEUTSCHE BANK AG\ | 34,710 | 305,000 | 0.22% | ||
| 20 | Bank of New York Mellon Corp | 27,237 | 240,000 | 0.17% | ||
| 21 | BANK OF MONTREAL /CAN/ | 25,126 | 222,000 | 0.16% | ||
| 22 | TUDOR INVESTMENT CORP ET AL | 24,917 | 220,000 | 0.16% | ||
| 23 | BlackRock Investment Management, LLC | 20,500 | 181,000 | 0.13% | ||
| 24 | ALPS ADVISORS INC | 19,356 | 171,000 | 0.12% | ||
| 25 | CREDIT SUISSE AG/ | 16,992 | 149,000 | 0.11% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 14,072 | 124,000 | 0.09% | ||
| 27 | NORTHERN TRUST CORP | 13,434 | 118,000 | 0.09% | ||
| 28 | ProShare Advisors LLC | 12,646 | 112,000 | 0.08% | ||
| 29 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 12,000 | 106,000 | 0.08% | ||
| 30 | Tower Research Capital LLC (TRC) | 2,455 | 21,000 | 0.02% | ||
| 31 | CITIGROUP INC | 2,172 | 19,000 | 0.01% | ||
| 32 | JPMORGAN CHASE & CO | 1,695 | 15,000 | 0.01% | ||
| 33 | D.A. DAVIDSON & CO. | 1,000 | 8,000 | 0.01% | ||
| 34 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 500 | 4,000 | 0.00% | ||
| 35 | BARCLAYS PLC | 110 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
