| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 6,747,332 | 84,207,000 | 49.10% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 1,619,977 | 20,217,000 | 11.79% | ||
| 3 | Visium Asset Management, LP | 1,400,000 | 17,472,000 | 10.19% | ||
| 4 | FRANKLIN RESOURCES INC | 1,158,345 | 14,456,000 | 8.43% | ||
| 5 | BOXER CAPITAL, LLC | 809,415 | 10,101,000 | 5.89% | ||
| 6 | BLACKROCK ADVISORS LLC | 307,195 | 3,834,000 | 2.24% | ||
| 7 | BlackRock Fund Advisors | 203,448 | 2,539,000 | 1.48% | ||
| 8 | Numeric Investors LLC | 185,810 | 2,319,000 | 1.35% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 174,650 | 2,180,000 | 1.27% | ||
| 10 | BlackRock Group LTD | 162,200 | 2,024,000 | 1.18% | ||
| 11 | Cormorant Asset Management, LP | 150,000 | 1,872,000 | 1.09% | ||
| 12 | VANGUARD GROUP INC | 94,291 | 1,177,000 | 0.69% | ||
| 13 | Alyeska Investment Group, L.P. | 88,005 | 1,098,000 | 0.64% | ||
| 14 | MORGAN STANLEY | 70,171 | 876,000 | 0.51% | ||
| 15 | SABBY MANAGEMENT, LLC | 60,313 | 753,000 | 0.44% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 59,600 | 744,000 | 0.43% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 51,681 | 644,000 | 0.38% | ||
| 18 | BlackRock Finance, Inc. | 40,700 | 508,000 | 0.30% | ||
| 19 | MARSHALL WACE, LLP | 40,542 | 506,000 | 0.30% | ||
| 20 | DEUTSCHE BANK AG\ | 32,402 | 403,000 | 0.23% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 31,195 | 389,000 | 0.23% | ||
| 22 | TUDOR INVESTMENT CORP ET AL | 28,223 | 352,000 | 0.21% | ||
| 23 | Iguana Healthcare Management, LLC | 25,000 | 312,000 | 0.18% | ||
| 24 | BANK OF MONTREAL /CAN/ | 24,700 | 308,000 | 0.18% | ||
| 25 | ALPS ADVISORS INC | 22,675 | 283,000 | 0.17% | ||
| 26 | ROYCE & ASSOCIATES LP | 18,622 | 232,000 | 0.14% | ||
| 27 | GOLDMAN SACHS GROUP INC | 18,045 | 225,000 | 0.13% | ||
| 28 | Bank of New York Mellon Corp | 17,377 | 217,000 | 0.13% | ||
| 29 | ADA INVESTMENT MANAGEMENT, LP | 16,419 | 205,000 | 0.12% | ||
| 30 | BlackRock Investment Management, LLC | 15,500 | 193,000 | 0.11% | ||
| 31 | CREDIT SUISSE AG/ | 15,145 | 188,000 | 0.11% | ||
| 32 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 15,000 | 187,000 | 0.11% | ||
| 33 | ProShare Advisors LLC | 13,843 | 173,000 | 0.10% | ||
| 34 | NORTHERN TRUST CORP | 13,434 | 168,000 | 0.10% | ||
| 35 | PANAGORA ASSET MANAGEMENT INC | 4,001 | 50,000 | 0.03% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 2,871 | 36,000 | 0.02% | ||
| 37 | CITIGROUP INC | 2,353 | 29,000 | 0.02% | ||
| 38 | UBS Group AG | 1,007 | 13,000 | 0.01% | ||
| 39 | BARCLAYS PLC | 283 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
