| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,536,092 | 140,762,000 | 45.87% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,259,367 | 43,545,000 | 14.19% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 2,191,977 | 29,285,000 | 9.54% | ||
| 4 | FRANKLIN RESOURCES INC | 1,431,745 | 19,128,000 | 6.23% | ||
| 5 | GOLDMAN SACHS GROUP INC | 991,597 | 13,248,000 | 4.32% | ||
| 6 | BOXER CAPITAL, LLC | 877,753 | 11,727,000 | 3.82% | ||
| 7 | BLACKROCK ADVISORS LLC | 530,373 | 7,086,000 | 2.31% | ||
| 8 | NEXTHERA CAPITAL LP | 340,000 | 4,542,000 | 1.48% | ||
| 9 | Opaleye Management Inc. | 310,000 | 4,142,000 | 1.35% | ||
| 10 | Alyeska Investment Group, L.P. | 272,163 | 3,636,000 | 1.18% | ||
| 11 | Ghost Tree Capital, LLC | 250,000 | 3,340,000 | 1.09% | ||
| 12 | BlackRock Group LTD | 232,002 | 3,100,000 | 1.01% | ||
| 13 | BlackRock Fund Advisors | 231,393 | 3,091,000 | 1.01% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 220,071 | 2,940,000 | 0.96% | ||
| 15 | VANGUARD GROUP INC | 206,936 | 2,764,000 | 0.90% | ||
| 16 | ROYCE & ASSOCIATES LP | 162,622 | 2,173,000 | 0.71% | ||
| 17 | Cormorant Asset Management, LP | 151,838 | 2,029,000 | 0.66% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 83,519 | 1,115,000 | 0.36% | ||
| 19 | TD ASSET MANAGEMENT INC | 78,707 | 1,052,000 | 0.34% | ||
| 20 | BlackRock Finance, Inc. | 66,792 | 892,000 | 0.29% | ||
| 21 | NORTHERN TRUST CORP | 64,033 | 856,000 | 0.28% | ||
| 22 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 62,000 | 828,000 | 0.27% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 59,700 | 798,000 | 0.26% | Call | |
| 24 | CREDIT SUISSE AG/ | 53,888 | 719,000 | 0.23% | ||
| 25 | DEUTSCHE BANK AG\ | 37,066 | 494,000 | 0.16% | ||
| 26 | Virtu KCG Holdings LLC | 32,798 | 438,000 | 0.14% | ||
| 27 | BlackRock Investment Management, LLC | 25,358 | 339,000 | 0.11% | ||
| 28 | BANK OF MONTREAL /CAN/ | 25,126 | 336,000 | 0.11% | ||
| 29 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 20,467 | 274,000 | 0.09% | ||
| 30 | DAFNA Capital Management LLC | 20,000 | 267,000 | 0.09% | ||
| 31 | HighTower Advisors, LLC | 19,000 | 257,000 | 0.08% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,800 | 251,000 | 0.08% | Put | |
| 33 | Bank of New York Mellon Corp | 16,761 | 224,000 | 0.07% | ||
| 34 | JANE STREET GROUP, LLC | 15,671 | 209,000 | 0.07% | ||
| 35 | MORGAN STANLEY | 12,715 | 169,000 | 0.06% | ||
| 36 | STATE STREET CORP | 11,400 | 153,000 | 0.05% | ||
| 37 | ProShare Advisors LLC | 10,858 | 145,000 | 0.05% | ||
| 38 | ELLINGTON MANAGEMENT GROUP LLC | 10,800 | 144,000 | 0.05% | ||
| 39 | Tower Research Capital LLC (TRC) | 9,121 | 122,000 | 0.04% | ||
| 40 | CUTLER GROUP LLC / CA | 5,094 | 68,000 | 0.02% | ||
| 41 | CITIGROUP INC | 2,776 | 37,000 | 0.01% | ||
| 42 | CUTLER GROUP LLC / CA | 18,900 | 30,000 | 0.01% | Call | |
| 43 | BANK OF AMERICA CORP /DE/ | 2,191 | 29,000 | 0.01% | ||
| 44 | D.A. DAVIDSON & CO. | 1,500 | 20,000 | 0.01% | ||
| 45 | PRELUDE CAPITAL MANAGEMENT, LLC | 1,363 | 18,000 | 0.01% | ||
| 46 | WELLS FARGO & COMPANY/MN | 750 | 10,000 | 0.00% | ||
| 47 | BARCLAYS PLC | 665 | 9,000 | 0.00% | ||
| 48 | UBS Group AG | 500 | 7,000 | 0.00% | ||
| 49 | GROUP ONE TRADING LLC | 83 | 1,000 | 0.00% | ||
| 50 | CUTLER GROUP LLC / CA | 2,100 | 1,000 | 0.00% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
