| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 7,752,487 | 51,321,000 | 50.39% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 1,691,977 | 11,201,000 | 11.00% | ||
| 3 | FRANKLIN RESOURCES INC | 1,245,945 | 8,248,000 | 8.10% | ||
| 4 | GOLDMAN SACHS GROUP INC | 957,166 | 6,336,000 | 6.22% | ||
| 5 | BOXER CAPITAL, LLC | 877,753 | 5,811,000 | 5.71% | ||
| 6 | NEXTHERA CAPITAL LP | 498,300 | 3,299,000 | 3.24% | ||
| 7 | BLACKROCK ADVISORS LLC | 404,575 | 2,678,000 | 2.63% | ||
| 8 | Opaleye Management Inc. | 295,000 | 1,953,000 | 1.92% | ||
| 9 | BlackRock Fund Advisors | 228,693 | 1,514,000 | 1.49% | ||
| 10 | BlackRock Group LTD | 200,100 | 1,325,000 | 1.30% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 199,657 | 1,322,000 | 1.30% | ||
| 12 | ROYCE & ASSOCIATES LP | 182,622 | 1,209,000 | 1.19% | ||
| 13 | Cormorant Asset Management, LP | 151,838 | 1,005,000 | 0.99% | ||
| 14 | Alyeska Investment Group, L.P. | 117,970 | 781,000 | 0.77% | ||
| 15 | VANGUARD GROUP INC | 110,529 | 731,000 | 0.72% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 62,949 | 416,000 | 0.41% | ||
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 62,000 | 410,000 | 0.40% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 55,037 | 364,000 | 0.36% | ||
| 19 | NORTHERN TRUST CORP | 50,732 | 336,000 | 0.33% | ||
| 20 | BlackRock Finance, Inc. | 50,600 | 335,000 | 0.33% | ||
| 21 | DEUTSCHE BANK AG\ | 38,362 | 252,000 | 0.25% | ||
| 22 | BANK OF MONTREAL /CAN/ | 25,126 | 166,000 | 0.16% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,839 | 157,000 | 0.15% | ||
| 24 | CREDIT SUISSE AG/ | 23,092 | 154,000 | 0.15% | ||
| 25 | BlackRock Investment Management, LLC | 20,500 | 136,000 | 0.13% | ||
| 26 | Bank of New York Mellon Corp | 17,377 | 115,000 | 0.11% | ||
| 27 | ProShare Advisors LLC | 12,814 | 85,000 | 0.08% | ||
| 28 | STATE STREET CORP | 11,900 | 78,000 | 0.08% | ||
| 29 | MORGAN STANLEY | 8,983 | 60,000 | 0.06% | ||
| 30 | UBS Group AG | 2,953 | 19,000 | 0.02% | ||
| 31 | CITIGROUP INC | 2,052 | 14,000 | 0.01% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 1,693 | 11,000 | 0.01% | ||
| 33 | D.A. DAVIDSON & CO. | 1,500 | 9,000 | 0.01% | ||
| 34 | WOLVERINE TRADING LP /BD | 349 | 2,248 | 0.00% | ||
| 35 | BARCLAYS PLC | 210 | 1,000 | 0.00% | ||
| 36 | Tower Research Capital LLC (TRC) | 4 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
