| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,536,092 | 173,951,000 | 44.96% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,400,397 | 56,141,000 | 14.51% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 2,191,977 | 36,190,000 | 9.35% | ||
| 4 | FRANKLIN RESOURCES INC | 1,392,245 | 22,986,000 | 5.94% | ||
| 5 | GOLDMAN SACHS GROUP INC | 968,819 | 15,995,000 | 4.13% | ||
| 6 | BOXER CAPITAL, LLC | 877,753 | 14,492,000 | 3.75% | ||
| 7 | BLACKROCK ADVISORS LLC | 628,230 | 10,372,000 | 2.68% | ||
| 8 | BlackRock Fund Advisors | 330,737 | 5,460,000 | 1.41% | ||
| 9 | Opaleye Management Inc. | 310,000 | 5,118,000 | 1.32% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 308,680 | 5,096,000 | 1.32% | ||
| 11 | Alyeska Investment Group, L.P. | 274,350 | 4,530,000 | 1.17% | ||
| 12 | VANGUARD GROUP INC | 253,601 | 4,187,000 | 1.08% | ||
| 13 | BlackRock Group LTD | 232,002 | 3,830,000 | 0.99% | ||
| 14 | Ghost Tree Capital, LLC | 225,000 | 3,715,000 | 0.96% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 175,000 | 2,889,000 | 0.75% | ||
| 16 | ROYCE & ASSOCIATES LP | 159,497 | 2,633,000 | 0.68% | ||
| 17 | Cormorant Asset Management, LP | 151,838 | 2,507,000 | 0.65% | ||
| 18 | EMORY UNIVERSITY | 143,691 | 2,372,000 | 0.61% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 110,497 | 1,824,000 | 0.47% | ||
| 20 | TD ASSET MANAGEMENT INC | 84,944 | 1,402,000 | 0.36% | ||
| 21 | NORTHERN TRUST CORP | 82,121 | 1,356,000 | 0.35% | ||
| 22 | MORGAN STANLEY | 68,584 | 1,132,000 | 0.29% | ||
| 23 | BlackRock Finance, Inc. | 67,392 | 1,113,000 | 0.29% | ||
| 24 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 56,800 | 938,000 | 0.24% | ||
| 25 | HighTower Advisors, LLC | 50,775 | 839,000 | 0.22% | ||
| 26 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 826,000 | 0.21% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 36,300 | 599,000 | 0.15% | ||
| 28 | Polar Capital LLP | 35,000 | 578,000 | 0.15% | ||
| 29 | DEUTSCHE BANK AG\ | 30,407 | 501,000 | 0.13% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,800 | 475,000 | 0.12% | Call | |
| 31 | BlackRock Investment Management, LLC | 25,358 | 419,000 | 0.11% | ||
| 32 | ALPS ADVISORS INC | 22,508 | 372,000 | 0.10% | ||
| 33 | BANK OF MONTREAL /CAN/ | 25,126 | 350,000 | 0.09% | ||
| 34 | Bank of New York Mellon Corp | 20,053 | 331,000 | 0.09% | ||
| 35 | VIRTUS ETF ADVISERS LLC | 16,347 | 270,000 | 0.07% | ||
| 36 | ProShare Advisors LLC | 15,474 | 255,000 | 0.07% | ||
| 37 | STATE STREET CORP | 11,400 | 188,000 | 0.05% | ||
| 38 | JGP Global Gestao de Recursos Ltda. | 11,380 | 188,000 | 0.05% | ||
| 39 | D.A. DAVIDSON & CO. | 9,550 | 157,000 | 0.04% | ||
| 40 | SG Americas Securities, LLC | 7,872 | 130,000 | 0.03% | ||
| 41 | CUTLER GROUP LLC / CA | 2,450 | 40,000 | 0.01% | ||
| 42 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 2,312 | 38,000 | 0.01% | ||
| 43 | CUTLER GROUP LLC / CA | 26,500 | 29,000 | 0.01% | Put | |
| 44 | Tower Research Capital LLC (TRC) | 1,591 | 26,000 | 0.01% | ||
| 45 | CITIGROUP INC | 1,438 | 24,000 | 0.01% | ||
| 46 | SIMPLEX TRADING, LLC | 1,345 | 22,000 | 0.01% | ||
| 47 | BARCLAYS PLC | 1,011 | 16,000 | 0.00% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 927 | 15,000 | 0.00% | ||
| 49 | Creative Planning | 500 | 8,000 | 0.00% | ||
| 50 | UBS Group AG | 500 | 8,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
