| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 6,747,332 | 94,935,000 | 52.01% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 1,532,151 | 21,557,000 | 11.81% | ||
| 3 | Visium Asset Management, LP | 1,400,000 | 19,698,000 | 10.79% | ||
| 4 | FRANKLIN RESOURCES INC | 1,107,045 | 15,576,000 | 8.53% | ||
| 5 | Redmile Group, LLC | 514,300 | 7,236,000 | 3.96% | ||
| 6 | BLACKROCK ADVISORS LLC | 307,300 | 4,324,000 | 2.37% | ||
| 7 | FIRST MANHATTAN CO. LLC. | 200,112 | 2,815,000 | 1.54% | ||
| 8 | BlackRock Group LTD | 162,200 | 2,282,000 | 1.25% | ||
| 9 | Cormorant Asset Management, LP | 150,000 | 2,111,000 | 1.16% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 149,359 | 2,101,000 | 1.15% | ||
| 11 | GREAT POINT PARTNERS LLC | 100,000 | 1,407,000 | 0.77% | ||
| 12 | Alyeska Investment Group, L.P. | 84,416 | 1,188,000 | 0.65% | ||
| 13 | SABBY MANAGEMENT, LLC | 60,000 | 844,000 | 0.46% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 59,600 | 839,000 | 0.46% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 56,015 | 788,000 | 0.43% | ||
| 16 | BlackRock Finance, Inc. | 47,500 | 668,000 | 0.37% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 47,103 | 662,000 | 0.36% | ||
| 18 | VANGUARD GROUP INC | 31,646 | 445,000 | 0.24% | ||
| 19 | DEUTSCHE BANK AG\ | 30,500 | 429,000 | 0.24% | ||
| 20 | BANK OF MONTREAL /CAN/ | 29,405 | 414,000 | 0.23% | ||
| 21 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 28,374 | 399,000 | 0.22% | ||
| 22 | TUDOR INVESTMENT CORP ET AL | 25,000 | 352,000 | 0.19% | ||
| 23 | ROYCE & ASSOCIATES LP | 18,622 | 262,000 | 0.14% | ||
| 24 | Bank of New York Mellon Corp | 17,377 | 244,000 | 0.13% | ||
| 25 | BlackRock Investment Management, LLC | 15,500 | 218,000 | 0.12% | ||
| 26 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 15,000 | 211,000 | 0.12% | ||
| 27 | NORTHERN TRUST CORP | 13,434 | 189,000 | 0.10% | ||
| 28 | Virtu KCG Holdings LLC | 12,531 | 176,000 | 0.10% | ||
| 29 | MORGAN STANLEY | 7,176 | 101,000 | 0.06% | ||
| 30 | Tower Research Capital LLC (TRC) | 3,729 | 53,000 | 0.03% | ||
| 31 | UBS Group AG | 1,385 | 19,000 | 0.01% | ||
| 32 | CITIGROUP INC | 41 | 1,000 | 0.00% | ||
| 33 | SUMMIT SECURITIES GROUP LLC | 100 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
