| 1 |
FRANKLIN RESOURCES INC |
11,946,100 |
6,690,000 |
22.42% |
|
|
| 2 |
BVF INC/IL |
7,291,600 |
4,083,000 |
13.68% |
|
|
| 3 |
BAKER BROS. ADVISORS LP |
4,774,434 |
2,674,000 |
8.96% |
|
|
| 4 |
Alyeska Investment Group, L.P. |
4,678,855 |
2,620,000 |
8.78% |
|
|
| 5 |
Alyeska Investment Group, L.P. |
4,118,800 |
2,307,000 |
7.73% |
Call |
|
| 6 |
SABBY MANAGEMENT, LLC |
3,539,779 |
1,982,000 |
6.64% |
|
|
| 7 |
VANGUARD GROUP INC |
3,382,483 |
1,894,000 |
6.35% |
|
|
| 8 |
ProQuest Associates IV LLC |
2,551,851 |
1,429,000 |
4.79% |
|
|
| 9 |
MPM ASSET MANAGEMENT LLC |
2,551,851 |
1,429,000 |
4.79% |
|
|
| 10 |
DEUTSCHE BANK AG\ |
1,915,800 |
1,072,000 |
3.59% |
|
|
| 11 |
SPHERA FUNDS MANAGEMENT LTD. |
1,374,900 |
770,000 |
2.58% |
|
|
| 12 |
PERKINS CAPITAL MANAGEMENT INC |
1,150,000 |
644,000 |
2.16% |
|
|
| 13 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
700,000 |
392,000 |
1.31% |
|
|
| 14 |
SHEPHERD KAPLAN KROCHUK, LLC |
581,886 |
326,000 |
1.09% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
560,868 |
314,000 |
1.05% |
|
|
| 16 |
Anson Funds Management LP |
432,007 |
242,000 |
0.81% |
|
|
| 17 |
Creative Planning |
378,700 |
212,000 |
0.71% |
|
|
| 18 |
RENAISSANCE TECHNOLOGIES LLC |
242,475 |
136,000 |
0.46% |
|
|
| 19 |
DIMENSIONAL FUND ADVISORS LP |
220,903 |
124,000 |
0.42% |
|
|
| 20 |
Bank of New York Mellon Corp |
167,295 |
94,000 |
0.31% |
|
|
| 21 |
Virtu KCG Holdings LLC |
137,908 |
77,000 |
0.26% |
|
|
| 22 |
NORTHERN TRUST CORP |
129,547 |
73,000 |
0.24% |
|
|
| 23 |
HighTower Advisors, LLC |
91,500 |
51,000 |
0.17% |
|
|
| 24 |
CITADEL ADVISORS LLC |
81,561 |
46,000 |
0.15% |
|
|
| 25 |
PIPER SANDLER & CO. |
56,200 |
31,000 |
0.10% |
Call |
|
| 26 |
MORGAN STANLEY |
44,800 |
25,000 |
0.08% |
|
|
| 27 |
UBS Group AG |
25,900 |
15,000 |
0.05% |
Call |
|
| 28 |
BlackRock Institutional Trust Company, N.A. |
22,218 |
12,000 |
0.04% |
|
|
| 29 |
GUGGENHEIM CAPITAL LLC |
21,059 |
12,000 |
0.04% |
|
|
| 30 |
ZACKS INVESTMENT MANAGEMENT |
20,000 |
11,000 |
0.04% |
|
|
| 31 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
14,226 |
8,000 |
0.03% |
|
|
| 32 |
STATE STREET CORP |
13,124 |
7,000 |
0.02% |
|
|
| 33 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
10,107 |
6,000 |
0.02% |
|
|
| 34 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
10,800 |
6,000 |
0.02% |
Call |
|
| 35 |
Cetera Advisor Networks LLC |
10,000 |
6,000 |
0.02% |
|
|
| 36 |
Genesis Wealth Advisors, LLC |
10,000 |
5,550 |
0.02% |
|
|
| 37 |
Pine River Capital Management L.P. |
687,500 |
4,000 |
0.01% |
|
|
| 38 |
EARNEST PARTNERS LLC |
5,400 |
3,000 |
0.01% |
|
|
| 39 |
WELLS FARGO & COMPANY/MN |
5,000 |
3,000 |
0.01% |
|
|
| 40 |
UBS Group AG |
6,793 |
3,000 |
0.01% |
|
|
| 41 |
Hoxton Financial, Inc. |
1,091 |
1,000 |
0.00% |
|
|
| 42 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,139 |
1,000 |
0.00% |
|
|
| 43 |
Godshalk Welsh Capital Management, Inc. |
2,000 |
1,000 |
0.00% |
|
|
| 44 |
Corbenic Partners LLC |
1,500 |
1,000 |
0.00% |
|
|
| 45 |
GROUP ONE TRADING LLC |
253 |
0 |
0.00% |
|
|
| 46 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
4 |
0 |
0.00% |
|
|
| 47 |
Pomelo Capital LLC |
250,000 |
0 |
0.00% |
Call |
|
| 48 |
B. Riley Wealth Management, Inc. |
597 |
0 |
0.00% |
|
|
| 49 |
PNC FINANCIAL SERVICES GROUP, INC. |
600 |
0 |
0.00% |
|
|
