| 1 |
FRANKLIN RESOURCES INC |
11,946,100 |
5,794,000 |
27.04% |
|
|
| 2 |
BVF INC/IL |
7,241,600 |
3,512,000 |
16.39% |
|
|
| 3 |
BAKER BROS. ADVISORS LP |
4,707,464 |
2,283,000 |
10.65% |
|
|
| 4 |
VANGUARD GROUP INC |
3,695,062 |
1,792,000 |
8.36% |
|
|
| 5 |
Alyeska Investment Group, L.P. |
2,969,381 |
1,440,000 |
6.72% |
Call |
|
| 6 |
MPM ASSET MANAGEMENT LLC |
2,551,851 |
1,250,000 |
5.83% |
|
|
| 7 |
ProQuest Associates IV LLC |
2,551,851 |
1,238,000 |
5.78% |
|
|
| 8 |
Alyeska Investment Group, L.P. |
2,398,892 |
1,163,000 |
5.43% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
1,374,900 |
667,000 |
3.11% |
|
|
| 10 |
DEUTSCHE BANK AG\ |
834,296 |
403,000 |
1.88% |
|
|
| 11 |
PERKINS CAPITAL MANAGEMENT INC |
643,000 |
312,000 |
1.46% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
602,094 |
292,000 |
1.36% |
|
|
| 13 |
SHEPHERD KAPLAN KROCHUK, LLC |
581,886 |
282,000 |
1.32% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
560,868 |
272,000 |
1.27% |
|
|
| 15 |
Creative Planning |
401,700 |
195,000 |
0.91% |
|
|
| 16 |
DIMENSIONAL FUND ADVISORS LP |
220,903 |
107,000 |
0.50% |
|
|
| 17 |
Bank of New York Mellon Corp |
167,295 |
81,000 |
0.38% |
|
|
| 18 |
NOMURA HOLDINGS INC |
129,000 |
64,000 |
0.30% |
|
|
| 19 |
NORTHERN TRUST CORP |
129,547 |
63,000 |
0.29% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
82,226 |
40,000 |
0.19% |
|
|
| 21 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
78,657 |
38,000 |
0.18% |
|
|
| 22 |
HighTower Advisors, LLC |
75,500 |
37,000 |
0.17% |
|
|
| 23 |
Virtu KCG Holdings LLC |
44,482 |
22,000 |
0.10% |
|
|
| 24 |
GUGGENHEIM CAPITAL LLC |
27,835 |
13,000 |
0.06% |
|
|
| 25 |
UBS Group AG |
24,960 |
12,000 |
0.06% |
|
|
| 26 |
TWO SIGMA SECURITIES, LLC |
23,697 |
11,000 |
0.05% |
|
|
| 27 |
UBS Group AG |
17,500 |
8,000 |
0.04% |
Call |
|
| 28 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
14,226 |
7,000 |
0.03% |
|
|
| 29 |
STATE STREET CORP |
13,124 |
6,000 |
0.03% |
|
|
| 30 |
Cetera Advisor Networks LLC |
10,000 |
5,000 |
0.02% |
|
|
| 31 |
Genesis Wealth Advisors, LLC |
10,000 |
4,605 |
0.02% |
|
|
| 32 |
GROUP ONE TRADING LLC |
8,285 |
4,000 |
0.02% |
|
|
| 33 |
BANK OF AMERICA CORP /DE/ |
5,800 |
3,000 |
0.01% |
|
|
| 34 |
EARNEST PARTNERS LLC |
5,400 |
3,000 |
0.01% |
|
|
| 35 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,139 |
1,000 |
0.00% |
|
|
| 36 |
ALLIANCEBERNSTEIN L.P. |
2,500 |
1,000 |
0.00% |
|
|
| 37 |
Pine River Capital Management L.P. |
687,500 |
1,000 |
0.00% |
|
|
| 38 |
Hoxton Financial, Inc. |
1,091 |
1,000 |
0.00% |
|
|
| 39 |
Corbenic Partners LLC |
1,500 |
1,000 |
0.00% |
|
|
| 40 |
PNC FINANCIAL SERVICES GROUP, INC. |
600 |
0 |
0.00% |
|
|
| 41 |
B. Riley Wealth Management, Inc. |
597 |
0 |
0.00% |
|
|
| 42 |
CITIGROUP INC |
255 |
0 |
0.00% |
|
|
| 43 |
MORGAN STANLEY |
700 |
0 |
0.00% |
|
|
| 44 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
4 |
0 |
0.00% |
|
|
