| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,315,551 | 11,800,000 | 17.60% | ||
| 2 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 901,202 | 8,084,000 | 12.06% | ||
| 3 | Broadfin Capital, LLC | 760,748 | 6,824,000 | 10.18% | ||
| 4 | Avoro Capital Advisors LLC | 755,300 | 6,775,000 | 10.11% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 638,906 | 5,731,000 | 8.55% | ||
| 6 | FRANKLIN RESOURCES INC | 424,381 | 3,807,000 | 5.68% | ||
| 7 | VANGUARD GROUP INC | 362,360 | 3,250,000 | 4.85% | ||
| 8 | BLUESTEIN R H & CO LLC | 361,575 | 3,243,000 | 4.84% | ||
| 9 | Lombard Odier Asset Management (USA) Corp | 315,259 | 2,828,000 | 4.22% | ||
| 10 | MORGAN STANLEY | 242,682 | 2,176,000 | 3.25% | ||
| 11 | Ghost Tree Capital, LLC | 202,500 | 1,816,000 | 2.71% | ||
| 12 | WALL STREET ASSOCIATES | 200,000 | 1,794,000 | 2.68% | ||
| 13 | Opaleye Management Inc. | 190,000 | 1,704,000 | 2.54% | ||
| 14 | PURA VIDA INVESTMENTS, LLC | 157,900 | 1,331,000 | 1.99% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 128,069 | 1,149,000 | 1.71% | ||
| 16 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 64,401 | 578,000 | 0.86% | ||
| 17 | BlackRock Fund Advisors | 42,167 | 378,000 | 0.56% | ||
| 18 | Integre Asset Management, LLC | 33,982 | 305,000 | 0.45% | ||
| 19 | Nine Chapters Capital Management LLC | 33,400 | 300,000 | 0.45% | ||
| 20 | BLACKROCK ADVISORS LLC | 29,829 | 268,000 | 0.40% | ||
| 21 | SABBY MANAGEMENT, LLC | 29,026 | 260,000 | 0.39% | ||
| 22 | A.R.T. Advisors, LLC | 28,160 | 252,000 | 0.38% | ||
| 23 | STIFEL FINANCIAL CORP | 26,925 | 242,000 | 0.36% | ||
| 24 | DEUTSCHE BANK AG\ | 26,845 | 240,000 | 0.36% | ||
| 25 | ROYAL BANK OF CANADA | 25,702 | 230,000 | 0.34% | ||
| 26 | CREDIT SUISSE AG/ | 25,099 | 225,000 | 0.34% | ||
| 27 | Candriam S.C.A. | 19,176 | 202,000 | 0.30% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,100 | 180,000 | 0.27% | Call | |
| 29 | TFS CAPITAL LLC | 18,278 | 164,000 | 0.24% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,200 | 163,000 | 0.24% | Put | |
| 31 | NORTHERN TRUST CORP | 17,300 | 156,000 | 0.23% | ||
| 32 | Virtu KCG Holdings LLC | 12,871 | 115,000 | 0.17% | ||
| 33 | ELLINGTON MANAGEMENT GROUP LLC | 12,676 | 114,000 | 0.17% | ||
| 34 | BlackRock Group LTD | 8,720 | 78,000 | 0.12% | ||
| 35 | UBS Group AG | 6,480 | 58,000 | 0.09% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 5,000 | 45,000 | 0.07% | ||
| 37 | CITADEL ADVISORS LLC | 4,814 | 43,000 | 0.06% | ||
| 38 | SIMPLEX TRADING, LLC | 4,108 | 36,000 | 0.05% | ||
| 39 | PANAGORA ASSET MANAGEMENT INC | 3,705 | 33,000 | 0.05% | ||
| 40 | BlackRock Investment Management, LLC | 2,658 | 24,000 | 0.04% | ||
| 41 | BlackRock Japan Co. Ltd | 1,650 | 15,000 | 0.02% | ||
| 42 | GLENMEDE TRUST CO NA | 1,000 | 8,000 | 0.01% | ||
| 43 | Walleye Trading LLC | 800 | 7,000 | 0.01% | ||
| 44 | BROWN BROTHERS HARRIMAN & CO | 500 | 4,000 | 0.01% | ||
| 45 | Tower Research Capital LLC (TRC) | 338 | 3,000 | 0.00% | ||
| 46 | Lehman Financial Resources, Inc. | 200 | 1,000 | 0.00% | ||
| 47 | CITIGROUP INC | 96 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
