| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,315,551 | 6,959,000 | 14.16% | ||
| 2 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,196,202 | 6,328,000 | 12.88% | ||
| 3 | Broadfin Capital, LLC | 890,748 | 4,712,000 | 9.59% | ||
| 4 | MILLENNIUM MANAGEMENT LLC | 779,499 | 4,124,000 | 8.39% | ||
| 5 | Opaleye Management Inc. | 570,000 | 3,015,000 | 6.14% | ||
| 6 | VANGUARD GROUP INC | 448,874 | 2,375,000 | 4.83% | ||
| 7 | FRANKLIN RESOURCES INC | 424,381 | 2,245,000 | 4.57% | ||
| 8 | MORGAN STANLEY | 411,746 | 2,179,000 | 4.43% | ||
| 9 | Avoro Capital Advisors LLC | 410,300 | 2,170,000 | 4.42% | ||
| 10 | Ghost Tree Capital, LLC | 398,300 | 2,107,000 | 4.29% | ||
| 11 | Lombard Odier Asset Management (USA) Corp | 334,689 | 1,771,000 | 3.60% | ||
| 12 | BLUESTEIN R H & CO LLC | 270,075 | 1,429,000 | 2.91% | ||
| 13 | PURA VIDA INVESTMENTS, LLC | 207,900 | 1,100,000 | 2.24% | ||
| 14 | CITADEL ADVISORS LLC | 206,225 | 1,091,000 | 2.22% | ||
| 15 | WALL STREET ASSOCIATES | 200,000 | 1,058,000 | 2.15% | ||
| 16 | SABBY MANAGEMENT, LLC | 158,140 | 837,000 | 1.70% | ||
| 17 | TURNER INVESTMENTS LLC | 122,000 | 645,000 | 1.31% | ||
| 18 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 94,401 | 499,000 | 1.02% | ||
| 19 | DIMENSIONAL FUND ADVISORS LP | 87,371 | 462,000 | 0.94% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 77,689 | 410,000 | 0.83% | ||
| 21 | Candriam S.C.A. | 69,000 | 365,000 | 0.74% | ||
| 22 | D. E. Shaw & Co., Inc. | 53,797 | 285,000 | 0.58% | ||
| 23 | A.R.T. Advisors, LLC | 49,848 | 263,000 | 0.54% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 46,543 | 246,000 | 0.50% | ||
| 25 | BlackRock Fund Advisors | 46,263 | 245,000 | 0.50% | ||
| 26 | Numeric Investors LLC | 45,178 | 239,000 | 0.49% | ||
| 27 | BLACKROCK ADVISORS LLC | 43,068 | 228,000 | 0.46% | ||
| 28 | NORTHERN TRUST CORP | 38,165 | 202,000 | 0.41% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,000 | 196,000 | 0.40% | Put | |
| 30 | Integre Asset Management, LLC | 33,965 | 180,000 | 0.37% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,977 | 153,000 | 0.31% | ||
| 32 | STIFEL FINANCIAL CORP | 26,925 | 142,000 | 0.29% | ||
| 33 | ROYAL BANK OF CANADA | 24,502 | 130,000 | 0.26% | ||
| 34 | Bank of New York Mellon Corp | 20,740 | 110,000 | 0.22% | ||
| 35 | OPPENHEIMER & CO INC | 20,300 | 108,000 | 0.22% | ||
| 36 | ELLINGTON MANAGEMENT GROUP LLC | 20,272 | 107,000 | 0.22% | ||
| 37 | Nine Chapters Capital Management LLC | 15,800 | 84,000 | 0.17% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,700 | 78,000 | 0.16% | Call | |
| 39 | UBS Group AG | 12,736 | 67,000 | 0.14% | ||
| 40 | BlackRock Group LTD | 8,720 | 46,000 | 0.09% | ||
| 41 | WELLS FARGO & COMPANY/MN | 5,270 | 28,000 | 0.06% | ||
| 42 | DEUTSCHE BANK AG\ | 5,432 | 28,000 | 0.06% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 5,000 | 26,000 | 0.05% | ||
| 44 | SIMPLEX TRADING, LLC | 3,417 | 18,000 | 0.04% | ||
| 45 | BlackRock Investment Management, LLC | 3,261 | 17,000 | 0.03% | ||
| 46 | BlackRock Japan Co. Ltd | 1,898 | 10,000 | 0.02% | ||
| 47 | WFG Advisors, LP | 1,274 | 7,000 | 0.01% | ||
| 48 | Walleye Trading LLC | 1,200 | 6,000 | 0.01% | ||
| 49 | GLENMEDE TRUST CO NA | 1,000 | 5,000 | 0.01% | ||
| 50 | BROWN BROTHERS HARRIMAN & CO | 500 | 3,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
