| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,365,000 | 8,627,000 | 20.89% | ||
| 2 | Broadfin Capital, LLC | 1,176,639 | 7,436,000 | 18.01% | ||
| 3 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 881,202 | 5,569,000 | 13.49% | ||
| 4 | Avoro Capital Advisors LLC | 755,300 | 4,773,000 | 11.56% | ||
| 5 | FRANKLIN RESOURCES INC | 424,381 | 2,682,000 | 6.49% | ||
| 6 | VANGUARD GROUP INC | 350,960 | 2,218,000 | 5.37% | ||
| 7 | BLUESTEIN R H & CO LLC | 314,170 | 1,986,000 | 4.81% | ||
| 8 | Lombard Odier Asset Management (USA) Corp | 279,141 | 1,764,000 | 4.27% | ||
| 9 | WALL STREET ASSOCIATES | 200,000 | 1,264,000 | 3.06% | ||
| 10 | MORGAN STANLEY | 198,701 | 1,256,000 | 3.04% | ||
| 11 | RENAISSANCE TECHNOLOGIES LLC | 104,900 | 663,000 | 1.61% | ||
| 12 | PURA VIDA INVESTMENTS, LLC | 90,000 | 569,000 | 1.38% | ||
| 13 | Integre Asset Management, LLC | 66,348 | 419,000 | 1.01% | ||
| 14 | DEUTSCHE BANK AG\ | 46,716 | 295,000 | 0.71% | ||
| 15 | BlackRock Fund Advisors | 44,598 | 282,000 | 0.68% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 42,245 | 267,000 | 0.65% | ||
| 17 | A.R.T. Advisors, LLC | 33,896 | 214,000 | 0.52% | ||
| 18 | SABBY MANAGEMENT, LLC | 600,000 | 192,000 | 0.46% | ||
| 19 | ROYAL BANK OF CANADA | 29,392 | 186,000 | 0.45% | ||
| 20 | STIFEL FINANCIAL CORP | 26,925 | 170,000 | 0.41% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 21,500 | 136,000 | 0.33% | Call | |
| 22 | DAFNA Capital Management LLC | 14,400 | 91,000 | 0.22% | SH | |
| 23 | NORTHERN TRUST CORP | 12,200 | 77,000 | 0.19% | ||
| 24 | EQUITEC SPECIALISTS, LLC | 7,000 | 44,000 | 0.11% | ||
| 25 | CITADEL ADVISORS LLC | 5,658 | 36,000 | 0.09% | ||
| 26 | BANK OF AMERICA CORP /DE/ | 5,000 | 32,000 | 0.08% | ||
| 27 | BlackRock Investment Management, LLC | 2,658 | 17,000 | 0.04% | ||
| 28 | GROUP ONE TRADING LLC | 1,717 | 11,000 | 0.03% | ||
| 29 | UBS Group AG | 1,445 | 9,000 | 0.02% | ||
| 30 | GLENMEDE TRUST CO NA | 1,000 | 6,000 | 0.01% | ||
| 31 | Tower Research Capital LLC (TRC) | 279 | 2,000 | 0.00% | ||
| 32 | Lehman Financial Resources, Inc. | 200 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
