| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,467,858 | 11,258,000 | 15.69% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,315,551 | 10,090,000 | 14.06% | ||
| 3 | MILLENNIUM MANAGEMENT LLC | 911,928 | 6,994,000 | 9.75% | ||
| 4 | Broadfin Capital, LLC | 890,748 | 6,832,000 | 9.52% | ||
| 5 | Opaleye Management Inc. | 565,000 | 4,334,000 | 6.04% | ||
| 6 | VANGUARD GROUP INC | 489,580 | 3,755,000 | 5.23% | ||
| 7 | FRANKLIN RESOURCES INC | 424,381 | 3,255,000 | 4.54% | ||
| 8 | Ghost Tree Capital, LLC | 350,000 | 2,685,000 | 3.74% | ||
| 9 | Lombard Odier Asset Management (USA) Corp | 348,641 | 2,674,000 | 3.73% | ||
| 10 | Avoro Capital Advisors LLC | 340,300 | 2,610,000 | 3.64% | ||
| 11 | CITADEL ADVISORS LLC | 221,821 | 1,701,000 | 2.37% | ||
| 12 | PURA VIDA INVESTMENTS, LLC | 217,900 | 1,671,000 | 2.33% | ||
| 13 | BLUESTEIN R H & CO LLC | 214,125 | 1,642,000 | 2.29% | ||
| 14 | OXFORD ASSET MANAGEMENT LLP | 199,619 | 1,531,000 | 2.13% | ||
| 15 | SABBY MANAGEMENT, LLC | 155,557 | 1,193,000 | 1.66% | ||
| 16 | TURNER INVESTMENTS LLC | 122,000 | 936,000 | 1.30% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 112,800 | 865,000 | 1.21% | Call | |
| 18 | MORGAN STANLEY | 98,848 | 758,000 | 1.06% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 94,990 | 728,000 | 1.01% | ||
| 20 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 94,401 | 724,000 | 1.01% | ||
| 21 | DIMENSIONAL FUND ADVISORS LP | 81,375 | 624,000 | 0.87% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 79,100 | 607,000 | 0.85% | Put | |
| 23 | D. E. Shaw & Co., Inc. | 73,771 | 566,000 | 0.79% | ||
| 24 | Candriam S.C.A. | 69,000 | 529,000 | 0.74% | ||
| 25 | Integre Asset Management, LLC | 64,317 | 493,000 | 0.69% | ||
| 26 | BlackRock Fund Advisors | 48,368 | 371,000 | 0.52% | ||
| 27 | BlackRock Institutional Trust Company, N.A. | 46,543 | 357,000 | 0.50% | ||
| 28 | BLACKROCK ADVISORS LLC | 44,622 | 342,000 | 0.48% | ||
| 29 | NORTHERN TRUST CORP | 38,165 | 293,000 | 0.41% | ||
| 30 | OPPENHEIMER & CO INC | 30,800 | 237,000 | 0.33% | ||
| 31 | ROYAL BANK OF CANADA | 23,492 | 180,000 | 0.25% | ||
| 32 | Bank of New York Mellon Corp | 21,210 | 163,000 | 0.23% | ||
| 33 | UBS Group AG | 12,994 | 100,000 | 0.14% | ||
| 34 | STIFEL FINANCIAL CORP | 12,350 | 95,000 | 0.13% | ||
| 35 | Quantitative Systematic Strategies LLC | 10,300 | 79,000 | 0.11% | ||
| 36 | CREDIT SUISSE AG/ | 10,001 | 77,000 | 0.11% | ||
| 37 | BlackRock Group LTD | 8,720 | 67,000 | 0.09% | ||
| 38 | CUTLER GROUP LLC / CA | 8,343 | 63,000 | 0.09% | ||
| 39 | Creative Planning | 6,138 | 47,000 | 0.07% | ||
| 40 | WELLS FARGO & COMPANY/MN | 5,270 | 40,000 | 0.06% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 5,000 | 38,000 | 0.05% | ||
| 42 | DEUTSCHE BANK AG\ | 3,934 | 30,000 | 0.04% | ||
| 43 | BlackRock Investment Management, LLC | 3,261 | 25,000 | 0.03% | ||
| 44 | SIMPLEX TRADING, LLC | 3,315 | 25,000 | 0.03% | ||
| 45 | BlackRock Japan Co. Ltd | 1,898 | 15,000 | 0.02% | ||
| 46 | Community Bank, N.A. | 1,362 | 10,000 | 0.01% | ||
| 47 | GROUP ONE TRADING LLC | 1,180 | 9,000 | 0.01% | ||
| 48 | WFG Advisors, LP | 1,038 | 8,000 | 0.01% | ||
| 49 | GLENMEDE TRUST CO NA | 1,000 | 7,000 | 0.01% | ||
| 50 | BROWN BROTHERS HARRIMAN & CO | 500 | 4,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
